Development of a noninvasive and localised blood-brain barrier opening system for the treatment of Alzheimer’s Disease
Current Alzheimer’s Disease (AD) drugs treat symptoms, but not the underlying disease process. Despite the availability of neurologically potent drugs (eg, inhibitors, antibodies), cerebral capillaries (ie, blood-brain barrier) block their entry into the brain.
The student will design, construct, and characterise a non-invasive ultrasound-based technology that drives systemically administered microbubbles into volumetric oscillations. This technology exerts mechanical stress from within the capillaries to increase permeability and allow drugs safe passage into the brain. The student will then use this technology to deliver drugs in transgenic AD mice, reduce AD pathology, and improve cognitive function.
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