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    Angeles P, Tai Y, Pavese N, Vaidyanathan Ret al., 2017,

    Assessing Parkinson's disease motor symptoms using supervised learning algorithms

    , 21st International Congress of Parkinson's Disease and Movement Disorders, Publisher: WILEY, ISSN: 0885-3185
    Angeles P, Tai Y, Pavese N, Wilson S, Vaidyanathan Ret al., 2017,

    Automated assessment of symptom severity changes during deep brain stimulation (DBS) therapy for Parkinson's disease.

    , Pages: 1512-1517

    Deep brain stimulation (DBS) is currently being used as a treatment for symptoms of Parkinson's disease (PD). Tracking symptom severity progression and deciding the optimal stimulation parameters for people with PD is extremely difficult. This study presents a sensor system that can quantify the three cardinal motor symptoms of PD - rigidity, bradykinesia and tremor. The first phase of this study assesses whether data recorded from the system during physical examinations can be used to correlate to clinician's severity score using supervised machine learning (ML) models. The second phase concludes whether the sensor system can distinguish differences before and after DBS optimisation by a clinician when Unified Parkinson's Disease Rating Scale (UPDRS) scores did not change. An average accuracy of 90.9 % was achieved by the best ML models in the first phase, when correlating sensor data to clinician's scores. Adding on to this, in the second phase of the study, the sensor system was able to pick up discernible differences before and after DBS optimisation sessions in instances where UPDRS scores did not change.

    Bass C, Helkkula P, De Paola V, Clopath C, Bharath AAet al., 2017,

    Detection of axonal synapses in 3D two-photon images

    , PLOS ONE, Vol: 12, ISSN: 1932-6203
    Bishop CA, Newbould RD, Lee JSZ, Honeyfield L, Quest R, Colasanti A, Ali R, Mattoscio M, Cortese A, Nicholas R, Matthews PM, Muraro PA, Waldman ADet al., 2017,

    Analysis of ageing-associated grey matter volume in patients with multiple sclerosis shows excess atrophy in subcortical regions

    , NEUROIMAGE-CLINICAL, Vol: 13, Pages: 9-15, ISSN: 2213-1582
    Burridge JH, Lee ACW, Turk R, Stokes M, Whitall J, Vaidyanathan R, Clatworthy P, Hughes A-M, Meagher C, Franco E, Yardley Let al., 2017,

    Telehealth, Wearable Sensors, and the Internet: Will They Improve Stroke Outcomes Through Increased Intensity of Therapy, Motivation, and Adherence to Rehabilitation Programs?

    , JOURNAL OF NEUROLOGIC PHYSICAL THERAPY, Vol: 41, Pages: S32-S38, ISSN: 1557-0576
    Castronovo M, Mrachacz-Kersting N, Landi F, Jørgensen HR, Severinsen K, Farina Det al., 2017,

    Motor Unit Coherence at Low Frequencies Increases Together with Cortical Excitability Following a Brain-Computer Interface Intervention in Acute Stroke Patients

    , Pages: 1001-1005, ISSN: 2195-3562

    © Springer International Publishing AG 2017. This study aims at investigating the neurophysiological correlates of increased cortical excitability following a Brain-Computer interface based intervention in three acute stroke survivors. The analysis was performed on high-density EMG signals recorded from the Tibialis Anterior muscle. All patients showed an increased excitability in the motor cortex area of interest following the BCI intervention. Moreover, coherence between motor unit spike trains increased in the frequency band 1–5, Hz, suggesting an increase in the common oscillatory drive to the target muscle.

    Cayco-Gajic NA, Clopath C, Silver RA, 2017,

    Sparse synaptic connectivity is required for decorrelation and pattern separation in feedforward networks

    , NATURE COMMUNICATIONS, Vol: 8, ISSN: 2041-1723
    Caze RD, Jarvis S, Foust AJ, Schultz SRet al., 2017,

    Dendrites Enable a Robust Mechanism for Neuronal Stimulus Selectivity

    , NEURAL COMPUTATION, Vol: 29, Pages: 2511-2527, ISSN: 0899-7667
    Dávila-Montero S, Barsakcioglu DY, Jackson A, Constandinou TG, Mason AJet al., 2017,

    Real-time clustering algorithm that adapts to dynamic changes in neural recordings

    , IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 690-693

    This work presents a computationally efficient real-time adaptive clustering algorithm that recognizes and adapts to dynamic changes observed in neural recordings. The algorithm consists of an off-line training phase that determines initial cluster positions, and an on-line operation phase that continuously tracks drifts in clusters and periodically verifies acute changes in cluster composition. Analysis of chronic recordings from non-human primates shows that adaptive clustering achieves an improvement of 14% in classification accuracy and demonstrates an ability to recognize acute changes with 78% accuracy, with up to 29% computational efficiency compared to the state-of-the-art. The presented algorithm is suitable for long-term chronic monitoring of neural activity in various applications such as neuroscience research and control of neural prosthetics and assistive devices.

    Datta G, Violante IR, Scott G, Zimmerman K, Santos-Ribeiro A, Rabiner EA, Gunn RN, Malik O, Ciccarelli O, Nicholas R, Matthews PMet al., 2017,

    Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis

    , MULTIPLE SCLEROSIS JOURNAL, Vol: 23, Pages: 1469-1478, ISSN: 1352-4585
    De Marcellis A, Palange E, Faccio M, Stanchieri GDP, Constandinou TGet al., 2017,

    A 250Mbps 24pJ/bit UWB-inspired Optical Communication System for Bioimplants

    , Turin, Italy, IEEE Biomedical Circuits and Systems (BioCAS) Conference, Pages: 132-135
    Dreier JP, Fabricius M, Ayata C, Sakowitz OW, Shuttleworth CW, Dohmen C, Graf R, Vajkoczy P, Helbok R, Suzuki M, Schiefecker AJ, Major S, Winkler MKL, Kang E-J, Milakara D, Oliveira-Ferreira AI, Reiffurth C, Revankar GS, Sugimoto K, Dengler NF, Hecht N, Foreman B, Feyen B, Kondziella D, Friberg CK, Piilgaard H, Rosenthal ES, Westover MB, Maslarova A, Santos E, Hertle D, Sanchez-Porras R, Jewell SL, Balanca B, Platz J, Hinzman JM, Lueckl J, Schoknecht K, Schoell M, Drenckhahn C, Feuerstein D, Eriksen N, Horst V, Bretz JS, Jahnke P, Scheel M, Bohner G, Rostrup E, Pakkenberg B, Heinemann U, Claassen J, Carlson AP, Kowoll CM, Lublinsky S, Chassidim Y, Shelef I, Friedman A, Brinker G, Reiner M, Kirov SA, Andrew RD, Farkas E, Gueresir E, Vatter H, Chung LS, Brennan KC, Lieutaud T, Marinesco S, Maas AIR, Sahuquillo J, Dahlem MA, Richter F, Herreras O, Boutelle MG, Okonkwo DO, Bullock MR, Witte OW, Martus P, van den Maagdenberg AMJM, Ferrari MD, Dijkhuizen RM, Shutter LA, Andaluz N, Schulte AP, MacVicar B, Watanabe T, Woitzik J, Lauritzen M, Strong AJ, Hartings JAet al., 2017,

    Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group

    , JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 37, Pages: 1595-1625, ISSN: 0271-678X
    Farina D, Castronovo AM, Vujaklija I, Sturma A, Salminger S, Hofer C, Aszmann Oet al., 2017,

    Common Synaptic Input to Motor Neurons and Neural Drive to Targeted Reinnervated Muscles

    , JOURNAL OF NEUROSCIENCE, Vol: 37, Pages: 11285-11292, ISSN: 0270-6474
    Feng P, Constandinou TG, Yeon P, Ghovanloo Met al., 2017,

    Millimeter-Scale Integrated and Wirewound Coils for Powering Implantable Neural Microsystems

    , IEEE Biomedical Circuits and Systems (BioCAS) Conference, Pages: 488-491
    Gao C, Ghoreishizadeh S, Liu Y, Constandinou TGet al., 2017,

    On-chip ID generation for multi-node implantable devices using SA-PUF

    , IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 678-681

    This paper presents a 64-bit on-chip identification system featuring low power consumption and randomness compensation for multi-node bio-implantable devices. A sense amplifier based bit-cell is proposed to realize the silicon physical unclonable function, providing a unique value whose probability has a uniform distribution and minimized influence from the temperature and supply variation. The entire system is designed and implemented in a typical 0.35 m CMOS technology, including an array of 64 bit-cells, readout circuits, and digital controllers for data interfaces. Simulated results show that the proposed bit-cell design achieved a uniformity of 50.24% and a uniqueness of 50.03% for generated IDs. The system achieved an energy consumption of 6.0 pJ per bit with parallel outputs and 17.3 pJ per bit with serial outputs.

    Ghajari M, Hellyer PJ, Sharp DJ, 2017,

    Computational modelling of traumatic brain injury predicts the location of chronic traumatic encephalopathy pathology

    , BRAIN, Vol: 140, Pages: 333-343, ISSN: 0006-8950
    Ghoreishizadeh SS, Haci D, Liu Y, Constandinou TGet al., 2017,

    A 4-Wire Interface SoC for Shared Multi- Implant Power Transfer and Full-duplex Communication

    , 8th IEEE Latin American Symposium on Circuits & Systems (LASCAS), Publisher: IEEE
    Ghoreishizadeh SS, Haci D, Liu Y, Donaldson N, Constandinou TGet al., 2017,

    Four-Wire Interface ASIC for a Multi-Implant Link

    Haci D, Liu Y, Constandinou TG, 2017,

    32-channel ultra-low-noise arbitrary signal generation platform for biopotential emulation

    , IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 698-701

    This paper presents a multichannel, ultra-low-noise arbitrary signal generation platform for emulating a wide range of different biopotential signals (e.g. ECG, EEG, etc). This is intended for use in the test, measurement and demonstration of bioinstrumentation and medical devices that interface to electrode inputs. The system is organized in 3 key blocks for generating, processing and converting the digital data into a parallel high performance analogue output. These blocks consist of: (1) a Raspberry Pi 3 (RPi3) board; (2) a custom Field Programmable Gate Array (FPGA) board with low-power IGLOO Nano device; and (3) analogue board including the Digital-to-Analogue Converters (DACs) and output circuits. By implementing the system this way, good isolation can be achieved between the different power and signal domains. This mixed-signal architecture takes in a high bitrate SDIO (Secure Digital Input Output) stream, recodes and packetizes this to drive two multichannel DACs, with parallel analogue outputs that are then attenuated and filtered. The system achieves 32-parallel output channels each sampled at 48kS/s, with a 10kHz bandwidth, 110dB dynamic range and uV-level output noise.

    Hartings JA, Shuttleworth CW, Kirov SA, Ayata C, Hinzman JM, Foreman B, Andrew RD, Boutelle MG, Brennan KC, Carlson AP, Dahlem MA, Drenckhahn C, Dohmen C, Fabricius M, Farkas E, Feuerstein D, Graf R, Helbok R, Lauritzen M, Major S, Oliveira-Ferreira AI, Richter F, Rosenthal ES, Sakowitz OW, Sanchez-Porras R, Santos E, Scholl M, Strong AJ, Urbach A, Westover MB, Winkler MKL, Witte OW, Woitzik J, Dreier JPet al., 2017,

    The continuum of spreading depolarizations in acute cortical lesion development: Examining Le(a)over-tilde-$o's legacy

    , JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 37, Pages: 1571-1594, ISSN: 0271-678X
    Huang H-Y, Farkhatdinov I, Arami A, Burdet Eet al., 2017,

    Modelling Neuromuscular Function of SCI Patients in Balancing

    , 3rd International Conference on NeuroRehabilitation (ICNR), Publisher: SPRINGER INTERNATIONAL PUBLISHING AG, Pages: 355-359, ISSN: 2195-3562
    Huntley JD, Hampshire A, Bor D, Owen AM, Howard RJet al., 2017,

    The importance of sustained attention in early Alzheimer's disease

    , International Journal of Geriatric Psychiatry, Vol: 32, Pages: 860-867, ISSN: 0885-6230

    Copyright © 2016 John Wiley & Sons, Ltd. Introduction: There is conflicting evidence regarding impairment of sustained attention in early Alzheimer's disease (AD). We examine whether sustained attention is impaired and predicts deficits in other cognitive domains in early AD. Methods: Fifty-one patients with early AD (MMSE > 18) and 15 healthy elderly controls were recruited. The sustained attention to response task (SART) was used to assess sustained attention. A subset of 25 patients also performed tasks assessing general cognitive function (ADAS-Cog), episodic memory (Logical memory scale, Paired Associates Learning), executive function (verbal fluency, grammatical reasoning) and working memory (digit and spatial span). Results: AD patients were significantly impaired on the SART compared to healthy controls (total error β = 19.75, p = 0.027). SART errors significantly correlated with MMSE score (Spearman's rho = −0.338, p = 0.015) and significantly predicted deficits in ADAS-Cog (β = 0.14, p = 0.004). Discussions: Patients with early AD have significant deficits in sustained attention, as measured using the SART. This may impair performance on general cognitive testing, and therefore should be taken into account during clinical assessment, and everyday management of individuals with early AD. Copyright © 2016 John Wiley & Sons, Ltd.

    Leene LB, Constandinou TG, 2017,

    Time Domain Processing Techniques Using Ring Oscillator-Based Filter Structures

    Liu Y, L Pereira J, Constandinou T, 2017,

    Event-driven processing for hardware-efficient neural spike sorting.

    , J Neural Eng

    The prospect of real-time and on-node spike sorting provides a genuine opportunity to push the envelope for large-scale integration of neural recording systems. In such systems the hardware resource, power requirements and data bandwidth increase linearly with channel count. Event-based (or data-driven) processing can here provide a new efficient means for hardware implementation that is completely activity dependant. In this work, we investigate using continuous time level-crossing sampling for efficient data representation and subsequent spike processing. We first compare signals (using synthetic neural datasets) that are encoded using this technique against conventional sampling. It is observed that considerably lower data rates are achievable when utilising 7 bits or less to represent the signals, whilst maintaining the signal fidelity. We then show how such a representation can be directly exploited by extracting simple time domain features from the bitstream to perform neural spike sorting. The proposed method is implemented in a low power FPGA platform to demonstrate the hardware viability. Results obtained using both MATLAB and reconfigurable logic (FPGA) hardware indicate that feature extraction and spike sorting accuracies can be achieved with comparable or better accuracy than reference methods whilst also requiring relatively low hardware cost.

    Liu Y, Luan S, Williams I, Rapeaux A, Constandinou TGet al., 2017,

    A 64-Channel Versatile Neural Recording SoC With Activity-Dependent Data Throughput.

    , IEEE Trans Biomed Circuits Syst, Vol: 11, Pages: 1344-1355

    Modern microtechnology is enabling the channel count of neural recording integrated circuits to scale exponentially. However, the raw data bandwidth of these systems is increasing proportionately, presenting major challenges in terms of power consumption and data transmission (especially for wireless systems). This paper presents a system that exploits the sparse nature of neural signals to address these challenges and provides a reconfigurable low-bandwidth event-driven output. Specifically, we present a novel 64-channel low-noise (2.1 V), low-power (23  W per analogue channel) neural recording system-on-chip (SoC). This features individually configurable channels, 10-bit analogue-to-digital conversion, digital filtering, spike detection, and an event-driven output. Each channel's gain, bandwidth, and sampling rate settings can be independently configured to extract local field potentials at a low data-rate and/or action potentials (APs) at a higher data rate. The sampled data are streamed through an SRAM buffer that supports additional on-chip processing such as digital filtering and spike detection. Real-time spike detection can achieve 2 orders of magnitude data reduction, by using a dual polarity simple threshold to enable an event driven output for neural spikes (16-sample window). The SoC additionally features a latency-encoded asynchronous output that is critical if used as part of a closed-loop system. This has been specifically developed to complement a separate on-node spike sorting coprocessor to provide a real-time (low latency) output. The system has been implemented in a commercially available 0.35-m CMOS technology occupying a silicon area of 19.1 mm (0.3 mm gross per channel), demonstrating a low-power and efficient architecture that could be further optimized by aggressive technology and supply voltage scaling.

    Luan S, Williams I, De-Carvalho F, Grand L, Jackson A, Quian Quiroga R, Constandinou TGet al., 2017,

    Standalone headstage for neural recording with real-time spike sorting and data logging

    , BNA Festival of Neuroscience, Publisher: The British Neuroscience Association Ltd
    Luo J, Firfilionis D, Ramezani R, Dehkhoda F, Soltan A, Degenaar P, Liu Y, Constandinou TGet al., 2017,

    Live demonstration: a closed-loop cortical brain implant for optogenetic curing epilepsy

    , IEEE Biomedical Circuits and Systems (BioCAS) Conference, Publisher: IEEE, Pages: 169-169
    Mace M, Rinne P, Kinany N, Bentley P, Burdet Eet al., 2017,

    Collaborative Gaming to Enhance Patient Performance During Virtual Therapy

    , 3rd International Conference on NeuroRehabilitation (ICNR), Publisher: SPRINGER INTERNATIONAL PUBLISHING AG, Pages: 375-379, ISSN: 2195-3562
    Maimon-Dror RO, Fernandez-Quesada J, Zito GA, Konnaris C, Dziemian S, Faisal AAet al., 2017,

    Towards free 3D end-point control for robotic-assisted human reaching using binocular eye tracking

    , Pages: 1049-1054, ISSN: 1945-7898

    © 2017 IEEE. Eye-movements are the only directly observable behavioural signals that are highly correlated with actions at the task level, and proactive of body movements and thus reflect action intentions. Moreover, eye movements are preserved in many movement disorders leading to paralysis (or amputees) from stroke, spinal cord injury, Parkinson's disease, multiple sclerosis, and muscular dystrophy among others. Despite this benefit, eye tracking is not widely used as control interface for robotic interfaces in movement impaired patients due to poor human-robot interfaces. We demonstrate here how combining 3D gaze tracking using our GT3D binocular eye tracker with custom designed 3D head tracking system and calibration method enables continuous 3D end-point control of a robotic arm support system. The users can move their own hand to any location of the workspace by simple looking at the target and winking once. This purely eye tracking based system enables the end-user to retain free head movement and yet achieves high spatial end point accuracy in the order of 6 cm RMSE error in each dimension and standard deviation of 4 cm. 3D calibration is achieved by moving the robot along a 3 dimensional space filling Peano curve while the user is tracking it with their eyes. This results in a fully automated calibration procedure that yields several thousand calibration points versus standard approaches using a dozen points, resulting in beyond state-of-the-art 3D accuracy and precision.

    Maslik M, Liu Y, Lande TS, Constandinou TGet al., 2017,

    A charge-based ultra-low power continuous-time ADC for data driven neural spike processing

    , IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 1420-1423

    The paper presents a novel topology of a continuous-time analogue-to-digital converter (CT-ADC) featuring ultra-low static power consumption, activity-dependent dynamic consumption, and a compact footprint. This is achieved by utilising a novel charge-packet based threshold generation method, that alleviates the requirement for a conventional feedback DAC. The circuit has a static power consumption of 3.75uW, with dynamic energy of 1.39pJ/conversion level. This type of converter is thus particularly well-suited for biosignals that are generally sparse in nature. The circuit has been optimised for neural spike recording by capturing a 3kHz bandwidth with 8-bit resolution. For a typical extracellular neural recording the average power consumption is in the order of ~4uW. The circuit has been implemented in a commercially available 0.35um CMOS technology with core occupying a footprint of 0.12

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