In video interviews, Imperial scientists explain how the state-of-the-art technology will help their research - <em>News</em>
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By Lucy Goodchild
Tuesday 18 May 2010
A new laser laboratory that will help scientists see how proteins become activated at a molecular level launched at Imperial College London on 29 April 2010.
The Ultrafast Spectroscopy Laboratory houses three state-of-the-art laser systems that can analyse the movements of proteins at a molecular level. The lasers work by generating intense light pulses that last for femtoseconds (0.000000000000001 seconds ) and the new lab will make Imperial one of the world’s biggest hubs for this kind of technology.
The lasers will be used to study light-activated processes such as photosynthesis. Researchers will measure the vibrations of atoms and molecules to understand how proteins involved in photosynthesis split water to release oxygen, a process that is currently not well understood.
Another project will look at a protein called phytochrome, which senses light in plants and some bacteria, to find out how it changes shape once it has absorbed light.
The laboratory is in the basement of the Wolfson building, to reduce any potential external vibrations that might interfere with the lasers. According to Dr Jasper van Thor from the Division of Molecular Biosciences, who has set up the lab, this is vital: “The lasers each sit on an optical table and a temperature change of just one degree Celsius can buckle these tables, changing the direction of the lasers on top. The basement location of the lab makes it ideal and protected from potentially disastrous traffic and tube vibrations.”
In this video, Dr Jasper van Thor, Dr Craig Lincoln and Ann Fitzpatrick, from the Division of Molecular Biosciences at Imperial, talk about the new laboratory, how it will help their research and what they are hoping to discover.
The lab has been set up thanks to a total of almost £3 million funding from the European Research Council (ERC), Biotechnology and Biological Sciences Research Council (BBSRC), the Royal Society and Imperial.
(click to download pdf)
Mike Robb (Imperial College London)
Theoretical Study of Photostability and Photoisomerization in Biological Systems
J Timothy Sage (Northeastern University Boston)
Site-Selective Vibrational Spectroscopy of Proteins, from Infrared to X-ray
Peter Rich (University College London)
Application of vibrational IR spectroscopy to protein structures and mechanisms
Steve Meech (University of East Anglia)
Ultrafast Optical Kerr Effect studies of water solvation - ions and peptides
Jennifer Herek (Twente University)
Coherent Control of Energy transfer in Natural and Artificial Photosynthesis
Peter Hamm (University of Zurich)
2D-IR Spectroscopy of Peptides and Proteins
Opening of Ultrafast Laboratory – Peter Knight
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