Citation

BibTex format

@article{Ciaccio:2015:10.1016/j.compbiomed.2015.04.032,
author = {Ciaccio, EJ and Coromilas, J and Ashikaga, H and Cervantes, DO and Wit, AL and Peters, NS and McVeigh, ER and Garan, H},
doi = {10.1016/j.compbiomed.2015.04.032},
journal = {Computers in Biology and Medicine},
pages = {254--263},
title = {Model of unidirectional block formation leading to reentrant ventricular tachycardia in the infarct border zone of postinfarction canine hearts.},
url = {http://dx.doi.org/10.1016/j.compbiomed.2015.04.032},
volume = {62},
year = {2015}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BACKGROUND: When the infarct border zone is stimulated prematurely, a unidirectional block line (UBL) can form and lead to double-loop (figure-of-eight) reentrant ventricular tachycardia (VT) with a central isthmus. The isthmus is composed of an entrance, center, and exit. It was hypothesized that for certain stimulus site locations and coupling intervals, the UBL would coincide with the isthmus entrance boundary, where infarct border zone thickness changes from thin-to-thick in the travel direction of the premature stimulus wavefront. METHOD: A quantitative model was developed to describe how thin-to-thick changes in the border zone result in critically convex wavefront curvature leading to conduction block, which is dependent upon coupling interval. The model was tested in 12 retrospectively analyzed postinfarction canine experiments. Electrical activation was mapped for premature stimulation and for the first reentrant VT cycle. The relationship of functional conduction block forming during premature stimulation to functional block during reentrant VT was quantified. RESULTS: For an appropriately placed stimulus, in accord with model predictions: (1) The UBL and reentrant VT isthmus lateral boundaries overlapped (error: 4.8±5.7mm). (2) The UBL leading edge coincided with the distal isthmus where the center-entrance boundary would be expected to occur. (3) The mean coupling interval was 164.6±11.0ms during premature stimulation and 190.7±20.4ms during the first reentrant VT cycle, in accord with model calculations, which resulted in critically convex wavefront curvature with functional conduction block, respectively, at the location of the isthmus entrance boundary and at the lateral isthmus edges. DISCUSSION: Reentrant VT onset following premature stimulation can be explained by the presence of critically convex wavefront curvature and unidirectional block at the isthmus entrance boundary when the premature stimulation interval is sufficientl
AU - Ciaccio,EJ
AU - Coromilas,J
AU - Ashikaga,H
AU - Cervantes,DO
AU - Wit,AL
AU - Peters,NS
AU - McVeigh,ER
AU - Garan,H
DO - 10.1016/j.compbiomed.2015.04.032
EP - 263
PY - 2015///
SN - 0010-4825
SP - 254
TI - Model of unidirectional block formation leading to reentrant ventricular tachycardia in the infarct border zone of postinfarction canine hearts.
T2 - Computers in Biology and Medicine
UR - http://dx.doi.org/10.1016/j.compbiomed.2015.04.032
UR - http://www.ncbi.nlm.nih.gov/pubmed/25966920
UR - http://hdl.handle.net/10044/1/27119
VL - 62
ER -