Patient with doctor


Professor Mary Morrell
Lead academic
+44 (0)20 7352 8121 ext 4023

Overview and aims

The section brings together two related areas of research, Chronic Respiratory Failure and Sleep and Ventilation

We aim to reduce the symptom burden for patients with chronic respiratory failure and sleep disorders through treatment of the disease itself, as well as by addressing the consequences of the disease such as hypoxaemia, hypercapnia, changes in muscle strength, cardiovascular and neurocognitive function. Our teams work closely together to share knowledge and skills, such as non-invasive ventilation, with a common goal of making a difference to patient care.

Based at Royal Brompton and Harefield hospitals, we are able to investigate highly prevalent clinical conditions such as chronic obstructive pulmonary disease (COPD) and obstructive sleep apnoea (OSA), as well as less common but life threatening diseases such as Duchenne muscular dystrophy. Importantly, our research findings improve treatment and inform clinical management of chronic lung disease.

All these conditions present significant challenges to our patients, their families and the health care system.  COPD and OSA are two of the most common respiratory diseases although treatment options are limited. Our research investigates the causes and consequences of these diseases to discover and develop new treatments. Our focus on education also ensures production of skills and knowledge of health workers in UK and beyond.

Research areas

Chronic Respiratory Failure

The Chronic Respiratory Failure group investigates respiratory muscle weakness in COPD, to develop physiological approaches for the palliation of advanced COPD and lung regeneration.

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Sleep and Ventilation

The Sleep and Ventilation group investigates the causes and cardiovascular / neurocognitive consequences of sleep disturbances, in particular sleep disordered breathing including OSA. The group has a special interest in home non-invasive ventilation that includes treatment of chronic respiratory failure in both pediatric and older populations.

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