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  • Journal article
    Filippidis F, Gerovasili V, Man W, Quint JKet al., 2016,

    Trends in mortality from respiratory system diseases in Greece during the financial crisis

    , European Respiratory Journal, Vol: 48, Pages: 1487-1489, ISSN: 1399-3003
  • Journal article
    Amaral AFS, Strachan DP, Gomez Real F, Burney PGJ, Jarvis DLet al., 2016,

    Lower lung function associates with cessation of menstruation: UK Biobank data

    , European Respiratory Journal, Vol: 48, Pages: 1288-1297, ISSN: 1399-3003

    Little is known about the effect of cessation of menstruation on lung function. The aims of the study were to examine the association of lung function with natural and surgical cessation of menstruation, and assess whether lower lung function is associated with earlier age at cessation of menstruation.The study was performed in 141 076 women from the UK Biobank, who had provided acceptable and reproducible spirometry measurements and information on menstrual status. The associations of lung function (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), spirometric restriction (FVC < lower limit of normal (LLN)), airflow obstruction (FEV1/FVC <LLN)) with cessation of menstruation and age at cessation of menstruation were assessed using regression analysis.Women who had natural cessation of menstruation showed a lower FVC (−42 mL; 95% CI −53– −30) and FEV1 (−34 mL; 95% CI −43– −24) and higher risk of spirometric restriction (adjusted odds ratio 1.27; 95% CI 1.18–1.37) than women still menstruating. These associations were stronger in women who had had a hysterectomy and/or oophorectomy. The earlier the natural cessation of menstruation, the lower the lung function. There was no clear association of lung function with age at hysterectomy and/or oophorectomy. Airflow obstruction was not associated with cessation of menstruation.Lower lung function associates with cessation of menstruation, especially if it occurs early in life.

  • Journal article
    Navaratnam V, Millett E, Hurst J, Thomas S, Smeeth L, hubbard R, Brown J, Quint JKet al., 2016,

    Bronchiectasis and the risk of cardiovascular disease: A population based study

    , Thorax, Vol: 72, Pages: 161-166, ISSN: 1468-3296

    Background There are limited data on the burden of cardiovascular comorbidities in people with bronchiectasis. Our cross-sectional study estimates the burden of pre-existing diagnoses of coronary heart disease (CHD) and stroke in people with bronchiectasis compared with the general population. The historical cohort study investigates if individuals with bronchiectasis are at increased risk of incident CHD and stroke events.Methods We used primary care electronic records from the Clinical Practice Research Datalink. The cross-sectional study used logistic regression to quantify the association between bronchiectasis and recorded diagnoses of CHD or stroke. Cox regression was used to investigate if people with bronchiectasis experienced increased incident CHD and strokes compared with the general population, adjusting for age, sex, smoking habit and other risk factors for cardiovascular disease.Results Pre-existing diagnoses of CHD (OR 1.33, 95% CI 1.25 to 1.41) and stroke (OR 1.92, 95% CI 1.85 to 2.01) were higher in people with bronchiectasis compared with those without bronchiectasis, after adjusting for age, sex, smoking and risk factors for cardiovascular disease. The rate of first CHD and stroke were also higher in people with bronchiectasis (HR for CHD 1.44 (95% CI 1.27 to 1.63) and HR for stroke 1.71 (95% CI 1.54 to 1.90)).Conclusion The risk of CHD and stroke are higher among people with bronchiectasis compared with the general population. An increased awareness of these cardiovascular comorbidities in this population is needed to provide a more integrated approach to the care of these patients.

  • Journal article
    De Matteis S, Jarvis DJ, Hutchings SH, Darnton AD, Fishwick DF, Sadhra SS, Rushton LR, Cullinan PCet al., 2016,

    Occupations associated with COPD risk in the large population-based UK Biobank cohort study

    , Occupational and Environmental Medicine, Vol: 73, Pages: 378-384, ISSN: 1351-0711

    Objectives COPD is a leading cause of morbidity and mortality worldwide. Exposure to occupational hazards is an important preventable risk factor but the contribution of specific occupations to COPD risk in a general population is uncertain. Our aim was to investigate the association of COPD with occupation in the UK population. Methods In 2006-2010 the UK Biobank cohort recruited 502,649 adults aged 40-69 years. COPD cases were identified by pre-bronchodilator FEV1/FVC<lower limit of normal (LLN) according to ATS/ERS guidelines. Current occupations were coded using the Standard Occupational Classification (SOC) 2000. Prevalence ratios (PRs) and 95% confidence intervals (CIs) of COPD for each SOC-coded job were estimated using a robust Poisson model adjusted for sex, age, recruitment centre and lifetime tobacco smoking. Analyses restricted to never smokers and non-asthmatics were also performed. Results Of the 353 occupations reported by 228,614 current working participants, several showed significantly increased COPD risk. Those at highest COPD risk were seafarers (PR=2.64;95%CI:1.59-4.38), coal mine operatives (PR=2.30;95%CI:1.00-5.31), cleaners (industrial: PR=1.96;95%CI:1.16-3.31 and domestic: PR=1.43;95%CI:1.28-1.59), roofers/tilers (PR=1.86;95%CI:1.29-2.67), packers/bottlers/canners/fillers (PR=1.60;95%CI:1.15-2.22), horticultural trades (PR=1.55;95%CI:0.97-2.50), food/drink/tobacco process operatives (PR=1.46;95%CI:1.11-1.93), floorers/wall tilers (PR=1.41;95%CI:1.00-2.00), chemical/related process operatives (PR=1.39;95%CI:0.98-1.97), postal workers/couriers (PR=1.35;95%CI:1.15-1.59), labourers in building/woodworking trades (PR=1.32;95%CI:1.04-1.68), school mid-day assistants (PR=1.32;95%CI:1.01-1.74), and kitchen/catering assistants (PR=1.30;95%CI:1.10-1.53). Associations were similar in analyses restricted to never smokers and non-asthmatics.Conclusions Selected occupations are associated with increased COPD risk in a large cross-sectional population-

  • Journal article
    Minelli C, Dean CH, Hind M, Couto Alves A, Amaral AFS, Siroux V, Huikari V, Soler Artigas M, Evans DM, Loth DW, Bossé Y, Postma DS, Sin D, Thompson J, Demenais F, Henderson J, Bouzigon E, Jarvis D, Jarvelin M, Burney Pet al., 2016,

    Association of Forced Vital Capacity with the Developmental Gene NCOR2

    , PLOS One, Vol: 11, ISSN: 1932-6203

    BackgroundForced Vital Capacity (FVC) is an important predictor of all-cause mortality in the absenceof chronic respiratory conditions. Epidemiological evidence highlights the role of early lifefactors on adult FVC, pointing to environmental exposures and genes affecting lung developmentas risk factors for low FVC later in life. Although highly heritable, a small number ofgenes have been found associated with FVC, and we aimed at identifying further geneticvariants by focusing on lung development genes.PLOS ONE | DOI:10.1371/journal.pone.0147388 February 2, 2016 1 / 17OPEN ACCESSCitation: Minelli C, Dean CH, Hind M, Alves AC,Amaral AFS, Siroux V, et al. (2016) Association ofForced Vital Capacity with the Developmental GeneNCOR2. PLoS ONE 11(2): e0147388. doi:10.1371/journal.pone.0147388Editor: Philipp Latzin, University Children's HospitalBasel, SWITZERLANDReceived: August 28, 2015Accepted: January 4, 2016Published: February 2, 2016Copyright: © 2016 Minelli et al. This is an openaccess article distributed under the terms of theCreative Commons Attribution License, which permitsunrestricted use, distribution, and reproduction in anymedium, provided the original author and source arecredited.Data Availability Statement: All relevant data arewithin the paper and its Supporting Information files.Funding: The authors have no support or funding toreport.Competing Interests: The authors have declaredthat no competing interests exist.MethodsPer-allele effects of 24,728 SNPs in 403 genes involved in lung development were tested in7,749 adults from three studies (NFBC1966, ECRHS, EGEA). The most significant SNP forthe top 25 genes was followed-up in 46,103 adults (CHARGE and SpiroMeta consortia) and5,062 children (ALSPAC). Associations were considered replicated if the replication p-valuesurvived Bonferroni correction (p<0.002; 0.05/25), with a nominal p-value considered assuggestive evidence. For SNPs with evidence of replication, effects on the expression levelsof n

  • Journal article
    Amaral AFS, Newson RB, Abramson MJ, Anto JM, Bono R, Corsico AG, de Marco R, Demoly P, Forsberg B, Gislason T, Heinrich J, Huerta I, Janson C, Jogi R, Kim JL, Maldonado J, Martinez-Moratalla Rovira J, Neukirch C, Nowak D, Pin I, Probst-Hensch N, Raherison-Semjen C, Svanes C, Urrutia Landa I, van Ree R, Versteeg SA, Weyler J, Zock JP, Burney PGJ, Jarvis DLet al., 2015,

    Changes in IgE sensitization and total IgE levels over 20 years of follow-up

    , Journal of Allergy and Clinical Immunology, Vol: 137, Pages: 1788-1795.e9, ISSN: 1097-6825

    Background: Cross-sectional studies have reported a lower prevalence of sensitisation in older adults, but few longitudinal studies have examined whether this is an aging or a year-of birth cohort effect. Objective: To assess changes in sensitisation and total IgE in a cohort of European adults as they aged over a 20-year period.Methods: Serum specific IgE to common aeroallergens (house dust mite, cat, grass) and total IgE were measured in 3206 adults, from 25 centres in the European Community Respiratory Health Survey, on three occasions over 20 years. Changes in sensitisation and total IgE were analysed by regression analysis, corrected for potential differences in laboratory equipment, and using inverse sampling-probability weights to account for non-response.Results: Over the 20-year follow-up, the prevalence of sensitisation to at least one of the three allergens fell from 29.4% to 24.8% (-4.6%, 95%CI: -7.0% to -2.1%). The prevalence of sensitisation to house dust mite (-4.3%, 95%CI: -6.0% to -2.6%) and cat (-2.1%, 95%CI: - 3.6% to -0.7%) fell more than sensitisation to grass (-0.6%, 95%CI: -2.5% to 1.3%). Age specific prevalence of sensitisation to house dust mite and cat did not differ between year-of birth cohorts, but sensitisation to grass was most prevalent in the most recent ones. Overall, total IgE fell significantly (geometric mean ratio: 0.63, 95%CI 0.58 to 0.68), at all ages, in all year-of-birth cohorts.Conclusion: Aging was associated with lower levels of sensitisation, especially to house dust mite and cat, after the age of 20.

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