Introduction to stream-specific compulsory modules

Genes Drugs and Stem Cells - Novel Therapies

Introduction to stream-specific compulsory modules

Genes and Nucleic Acid-Based Therapies - Griesenbach

The gene and nucleic acid-based therapies stream will cover a range of disease indications for which gene therapy has been, or is being, developed.

This module will allow in depth discussion on the need for careful selection of gene therapy vectors for specific disease indications as well as problems encountered along the way. 

Information on stream Genes and Nucleic Acid-Based Therapies

Genes and Nucleic Acid-Based Therapies - Griesenbach

Professor Uta Griesenbach provides an overview of her stream specific core module.

The gene and nucleic acid-based therapies stream will cover a range of disease indications for which gene therapy has been, or is being, developed.

This module will allow in depth discussion on the need for careful selection of gene therapy vectors for specific disease indications as well as problems encountered along the way. 

Information on stream Regenerative Medicine

Regenerative Medicine - Rankin

Professor Sara Rankin provides an overview of her stream specific core module.

In this stream lectures will progress from covering fundamental developmental and stem cell biology, through to the practicalities of clinical trials and the commercialization of stem cell therapies. 

At Imperial we are very keen to engage the public with our science and therefore in this stream we have lectures and a workshop  covering innovative ways to engage the public in science.

Information on stream New Horizons in Pharmacology

New Horizons in Pharmacology - Mitchell

Professor Jane Mitchell provides an overview of her stream specific core module.

In this stream lectures will include the history of drugs, from examples like aspirin which is centuries old, right through to new types of drugs made from antibodies or delivered in stem cells. Providing students with a full understanding of drugs from their early conception right up to the latest discoveries.

Our course includes lectures from Imperial College and other world leading institutions that are at the cutting edge of drug development. We also include lectures from professionals in the drug industry and who specialize in the ethics and financial aspects of research and bringing a drug to the market. 


Handbooks

This page is currently under construction and no handbooks are available yet. Soon you will be able to select your programme below to view and download the handbook.

Healthcare, genes, genomics

Nurse with patient

Cardiovascular and Respiratory Healthcare

researcher looks at vial

Genes, Drugs and Stem Cells - Novel Therapies

researcher looks at equipment

Genomic Medicine

Healthcare, genes, genomics

Doctor looks at screen

Innovations in Cardiological Science

ultrasound on patient

Medical Ultrasound

Person on treadmill

Preventive Cardiology


Further information on programme modules

Genes Drugs and Stem Cells - Novel Therapies

Modules

Compulsory modules

Science and Research Skill Module:

Basic ethical principles related to pre-clinical and clinical research (including special consideration for working with children), the human tissue act and relevant tissue governance in addition to basic statistics and experimental design will be taught. A number of transferable and research skill sessions will be timetabled including note taking, efficient reading, database searches and referencing, oral and written presentation skills and critical appraisal of research papers in form of journal clubs. An important aspect of this model is also to make students aware of commercialisation strategies including the importance of IP protection and patents as well as the health economy. These issues will be discussed from an academic and industry view. In addition the students will be familiarised with all necessary safety regulations for working at Imperial College.

Key concepts in Gene and Nucleic Acid-Based Therapies:

Students will be introduced to the key concepts of human genetics and genomics that underpin the development of gene and nucleic acid-based therapies. This includes lectures on monogenic and complex diseases, the complexities of genotype/phenotype correlations, key principles of gene regulation as well as generation of suitable animal models to mimic human disease. Students will also be introduced to ethical considerations related to genetic testing and data release. In addition students will be familiarised with basic tools related to gene and nucleic acid-based therapies such as commonly used viral and non-viral vectors and vector production methods. A couple of representative disease targets will also be discussed. PCR-based genotyping will be taught in a practical. Transferrable skills will be developed when preparing and delivering debates covering controversial topics within the subject area. 

Key concepts in Regenerative Medicine:

This module will focus on providing the basis and key concepts of  areas essential to Regenerative medicine. Lectures and journal clubs will focus on the following topics:  Developmental Biology, Stem cell Biology, Animal models for regenerative medicine, Clinical trials. The series of lectures, with intercalated workshops and journal clubs, will take the students from the very basic concepts of development and of the current knowledge about stem cells, to the experimental models which have been developed to investigate the use of stem cells in disease. The module will then move to human studies, discussing clinical trials (including cell therapy) to provide a methodological prospective and to then review the current status of trials using regenerative medicine. The course will also provide an introduction to Biomaterials for regenerative medicine. The module will discuss and describe different strategies to engage the public in the research, ethics and clinical translation of regenerative medicine.

Key concepts in New Horizons in Pharmacology

The aim of the Key concepts in Pharmacology module is to provide the student with a basic understanding of how drugs target disease, disease mechanisms and how the drug development process has evolved over the history of pharmacology, how it will change in the future and differs for common versus rare conditions. The cutting edge content of the course will assist the student in taking a more proactive role in the development of novel therapeutic agents and assessment of their safety.

Advanced studies module

Advanced studies in Gene and Nucleic Acid-Based Therapies:

The content of this module will build on teaching delivered in the stream-specific core module (Key Concepts in Gene and Nucleic acid-based therapies). This module will comprehensively cover the current know-how on gene and nucleic acid based therapies and in combination with the project provide student with adequate tools to pursue further postgraduate studies or a non-academic career in the field. Students will become familiar with a range of disease specific clinical application related to gene and nucleic acid-based therapies to gain an advanced understanding. This will involve familiarisation with principles related to good clinical practice (GCP) and other regulatory requirements, as well as the concepts of GMP manufacturing. The history and development of the first approved gene therapy product will be discussed. Through relevant practicals, student will gain experience in techniques relevant for the 6 month research projects.

Advanced studies in Regenerative Medicine:

In this module students will learn about the tools and technologies utilised in the field of regenerative medicine and the use of stem cells to develop disease models in culture (so called disease in a dish). Lectures will cover cutting edge research and new patents relating to regenerative pharmacology, covering the molecular pathways and drugs being used for stem cell differentiation in vitro and for the mobilization and activation of stem cells in vivo. The basic science of differentiating stem cells into cardiac cells will be covered in addition to the practicalities of scale up, to generate robust and reproducible cultures. In addition, the module will focus on tissue engineering and translational strategies for regenerative medicine.

Advanced studies in New Horizons in Pharmacology

The content of this module will build on teaching delivered in the key concept module. This module will comprehensively cover how Pharmacology continues to identify new endogenous pathways (eg cytokines) that can be targeted to develop new drugs. In addition the idea of how nanomedicine approaches are being used to make new formulations of drugs and what this means in terms of testing efficacy and toxicity will be addressed. Finally, principals of personalised medicine in current clinical practice and into the future will be covered. This in combination with the project will provide student with adequate tools to pursue further postgraduate studies or a non-academic career in the field.

6 month research project

Following successful completion of the 5 taught modules, student will conduct a 6 months research project. The project will be related to one of the three course streams; Gene and Nucleic Acid-based therapies, Regenerative Medicine or  New Horizons in Pharmacology. Students will join an established research laboratory and will conduct work supervised by academic staff. At the end of the project students will prepare a project report (approximately 10,000 words) and a oral presentation.