BBSRC Industrial CASE partnership
Two 4yr PhD BBSRC-Industrial CASE partnership studentships commencing in Autumn 2017
Understanding the interactions of the lung microbiome and its relationship with differential protein, transcriptomic and cellular data
Developing methods for multi-omic data integration and utilisation in pharmaco-genetic and –genomic analysis of drug responders and non-responders
Applications are invited from candidates with a BSc or Master’s degree (or equivalent) in Biological Sciences or a related discipline, for a 4 year PhD studentship to investigate the “Understanding of how the lung microbiome is associated with severe asthma omic data” and in “Developing methods for multi-omic data integration of drug responders and non-responders in severe asthma” carried out in partnership with GlaxoSmithKline. Experience in bioinformatic analysis would be an advantage but not essential.
Asthma is a chronic inflammatory disease of the airway that mostly responds to topical corticosteroids. However, 5-10% of patients have severe disease that fails to respond well to treatment. These bioinformatic projects utilise multi-omic data obtained from the pan-European U-BIOPRED severe asthma cohort to investigate the role of the microbiome in directing biological processes associated with subtypes of severe asthma whilst the second project uses network fusion and other approaches to merge different omics datasets and investigate drug responses. The projects will involve state-of-the-art bioinformatics approaches to analyse metagenomic, genetic, transcriptomic, proteomic and metabolomics data stored within the TransMart KM system.
The studentship will be funded for up to 4 years with a tax free bursary in excess of £18,500 per annum. Tuition fees at the Home/EU rate will also be paid.
To be eligible for a full award a student must fulfil all the following criteria:
- Have settled status in the UK, meaning they have no restrictions on how long they can stay.
- Been ‘ordinarily resident’ in the UK for three years prior to the start of the studentship. This means they must have been normally residing in the UK (apart from temporary or occasional absences).
- Have not been residing in the UK wholly or mainly for the purpose of full-time education (this does not apply to UK or EU nationals).
The student will work within the groups of Professors Ian Adcock, Fan Chung and Yike Kuo which are based within the Airway Disease section of the National Heart and Lung Institute, Imperial College London, at the Royal Brompton Campus and the Data Science Institute at the South Kensington Campus, with approximately 3-6 months spent at GSK’s site in Stevenage with the Industrial PI Dr John Riley.
The National Heart and Lung Institute provides an exciting environment, with state of the art facilities and excellent opportunities for PhD student training including research seminars and journal clubs. In addition, the institute provides extensive collaborative opportunities with other research groups.
How to Apply
Applicants must hold, or expect to obtain, a first or upper second-class undergraduate degree or UK equivalent, along with a Masters, both in an appropriate subject from a recognised academic institution, and must fulfil the College’s admissions criteria.
To apply please send to Professor Ian Adcock:
- a CV
- a one page personal statement
- the names and addresses of at least two academic referees .
Please note that candidates must fulfil College admissions criteria - details of College entry requirements.
Application deadline: Now closed.
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