Infection, Inflammation and metabolism in fibrotic lung disease
Research by the Inflammation Repair and Development section
3.5yr PhD funded through the NHLI Foundation - starting Autumn 2017
Applications are invited from candidates with a Master’s degree (or equivalent) in cellular, molecular or clinical immunology or a related discipline for a 3.5 year PhD studentship to investigate the pathogenesis of idiopathic pulmonary fibrosis (IPF).
Idiopathic pulmonary fibrosis is a progressive disease of unknown etiology with a 5 year survival rate of only 20%. It affects over 32,000 individuals in the UK and current evidence suggests IPF develops in genetically susceptible individuals after repeated episodes of alveolar injury. This project will build upon work within the group to understand the interaction of lung-resident inflammatory cells, the airway epithelium, lung microbiome and metabolome in driving the development and progression of pulmonary fibrosis.
The studentship has been made possible by the NHLI Foundation, and will be funded for 3.5 years with a tax free bursary of £18,000 per annum. Tuition fees at the Home/EU rate will also be paid.
The studentship will be based within the Inflammation Repair and Development (IRD) section and will be supervised by Dr Philip Molyneaux and Professor Clare Lloyd. The successful candidate will receive training in a wide variety of techniques including:
- in vitro cell culture (stimulation and analysis);
- flow cytometry, extracellular staining for phenotyping of cells and intracellular for cytokine analysis;
- cell sorting using magnetic bead systems;
- ELISAs and multiplex assays for cytokines and chemokines;
- RNA extractions and qPCR;
- DNA extractions, qPCR, 16S sequencing and data analysis, migration assays;
- development of complex co-culture systems;
- imaging (confocal microscopy, intravital microscopy, imaging of precision cut lung slices).
The National Heart and Lung Institute provides an exciting environment, with state of the art facilities and excellent opportunities for PhD student training including research seminars and journal clubs. In addition, the institute provides extensive collaborative opportunities with other research groups.
All students will belong to Imperial’s award winning Graduate School which provides a comprehensive Professional Skills Programme.
How to Apply
Applicants must hold, or expect to obtain, a first or upper second-class undergraduate degree or UK equivalent, along with a Masters, both in an appropriate subject from a recognised academic institution, and must fulfil the College’s admissions criteria.
To apply please send Dr Phil Molyneaux the following:
- a CV
- a 400 word personal statement
- the names and addresses of at least two academic referees.
For informal enquiries regarding the PhD project please contact Dr Phil Molyneaux.
Please note that candidates must fulfil College admissions criteria - details of College entry requirements.
Application deadline: Now closed.
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