Investigation of the relationship between AMPK and PKCε and their role in the regulation of endothelial cell metabolism and function
British Heart Foundation - Imperial Centre for Translational and Experimental Medicine (ICTEM) 4-year MRes/PhD Studentship, Imperial College London
CALL FOR APPLICATIONS FOR OCTOBER 2018
Project title: Investigation of the relationship between AMPK and PKCε and their role in the regulation of endothelial cell metabolism and function.
Applications are invited for a British Heart Foundation (BHF) 4 year MRes/PhD studentship starting in October 2018 at the Imperial Centre for Translational and Experimental Medicine (ICTEM), Hammersmith Campus. The studentships are fully funded through a BHF training grant made to Professor Sian Harding and it will cover tuition fees (at the Home/EU rate) and a tax-free stipend starting from £22,278 per annum for a total of 4 years. In addition, there is a consumable allowance of £50,000 and £1000 travel award per studentship.
This project brings together groups working in the Vascular Sciences Division of the National Heart and Lung Institute and the MRC London Medical Science Institute, both of which are located at the Hammersmith Hospital Campus, Imperial College. The collaboration between our three groups brings together expertise in cardiovascular biology, endothelial cell function and energy metabolism and provides an excellent platform for carrying out the project.
Imperial College London provides excellent opportunities for research student training. All students benefit from a full programme of training in research and transferable skills organised through the Graduate School, the quality of which has been recognised several times at the Times Higher Education (THE) Awards.
The BHF 4-year MRes/PhD studentships at ICTEM typically comprises a 1-year MRes in Biomedical Research, followed by a 3 year PhD. During the MRes year, students undertake two laboratory projects which will prepare them for the Ph.D. The overall aim of the project is to investigate the role of AMPK and PKCε in ECs, with the direction of the PhD work being informed by the outcome of the MRes studies. We anticipate that this will include exploring further the mechanistic link between AMPK and PKC, as well as focussing on the role of the two kinases on EC metabolism and function. The project will involve a broad range of techniques and approaches, including biochemical/molecular biology techniques (enzyme assays, western blotting, RT-PCR), cell biology (isolation and culture of primary human and mouse cells, immunohistochemical techniques with confocal microscopy), mitochondrial respiration and in vivo mouse physiological techniques.
The successful candidate will be based in the Birdsey, Carling and Mason groups at the Hammersmith Campus for a period of their study. They will also join a cohort of Ph.D. students affiliated with the BHF Centres at Imperial, with particular interests in regenerative medicine and novel technologies. They will also link to the wider Imperial College through activities such as the Imperial Stem Cell and Regenerative Medicine Network.
Applicants must hold, or expect to obtain, a first or upper second-class honours degree or equivalent in an appropriate subject from a recognised academic institution. Evidence of previous research experience in animal physiology (e.g. personal licence), biochemistry, cell biology and/or molecular biology at an academic or industrial research organisation would be desirable. Candidates must fulfil College admissions criteria and meet BHF residency requirements.
How to Apply
To apply, please email Jinata Subba (email@example.com) with the following documents.
- Your CV
- The names and addresses of at least two academic referees
- A personal statement of no more than 1,000 words explaining your interest in the project
Please assume that your application has not been successful if you have not heard from us within a month of the closing date.
Closing date for all applications: Sunday 28 January 2018
Interviews will be held in February 2018