@article{Miguel-Aliaga:2018:10.1534/genetics.118.300224,
author = {Miguel-Aliaga, I and Jasper, H and Lemaitre, B},
doi = {10.1534/genetics.118.300224},
journal = {Genetics},
pages = {357--396},
title = {Anatomy and physiology of the digestive tract of drosophila melanogaster},
url = {http://dx.doi.org/10.1534/genetics.118.300224},
volume = {210},
year = {2018}
}

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TY  - JOUR
AB  - The gastrointestinal tract has recently come to the forefront of multiple research fields. It is now recognized as a major sourceof signals modulating food intake, insulin secretion and energy balance. It is also a key player in immunity and, through its interaction withmicrobiota, can shape our physiology and behavior in complex and sometimes unexpected ways. The insect intestine had remained, bycomparison, relatively unexplored until the identification of adult somatic stem cells in the Drosophila intestine over a decade ago. Sincethen, a growing scientific community has exploited the genetic amenability of this insect organ in powerful and creative ways. By doingso, we have shed light on a broad range of biological questions revolving around stem cells and their niches, interorgan signaling andimmunity. Despite their relatively recent discovery, some of the mechanisms active in the intestine of flies have already been shown to bemore widely applicable to other gastrointestinal systems, and may therefore become relevant in the context of human pathologies such asgastrointestinal cancers, aging, or obesity. This review summarizes our current knowledge of both the formation and function of theDrosophila melanogaster digestive tract, with a major focus on its main digestive/absorptive portion: the strikingly adaptable adult midgut.
AU  - Miguel-Aliaga,I
AU  - Jasper,H
AU  - Lemaitre,B
DO  - 10.1534/genetics.118.300224
EP  - 396
PY  - 2018///
SN  - 0016-6731
SP  - 357
TI  - Anatomy and physiology of the digestive tract of drosophila melanogaster
T2  - Genetics
UR  - http://dx.doi.org/10.1534/genetics.118.300224
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000449398800003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/70548
VL  - 210
ER  - 

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