@article{Ekelund:2015:10.3945/ajcn.114.100065,
author = {Ekelund, U and Ward, HA and Norat, T and Luan, J and May, AM and Weiderpass, E and Sharp, SJ and Overvad, K and Ostergaard, JN and TjOnneland, A and Johnsen, NF and Mesrine, S and Foamier, A and Fagherazzi, G and Trichopoulou, A and Lagiou, P and Trichopoulos, D and Li, K and Kaaks, R and Ferrari, P and Licaj, I and Jenab, M and Bergmann, M and Boeing, H and Palli, D and Sieri, S and Panico, S and Tumino, R and Vineis, P and Peeters, PH and Monnikhof, E and Bueno-de-Mesquita, HB and Ramon, Quiros J and Agudo, A and Sanchez, M-J and Maria, Huerta J and Ardanaz, E and Arriola, L and Hedblad, B and Wirfalt, E and Sand, M and Johansson, M and Key, TJ and Travis, RC and Khaw, K-T and Brage, S and Wareham, NJ and Riboli, E},
doi = {10.3945/ajcn.114.100065},
journal = {American Journal of Clinical Nutrition},
pages = {613--621},
title = {Physical activity and all-cause mortality across levels of overall and abdominal adiposity in European men and women: the European Prospective Investigation into Cancer and Nutrition Study (EPIC)},
url = {http://dx.doi.org/10.3945/ajcn.114.100065},
volume = {101},
year = {2015}
}

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TY  - JOUR
AB  - Background: The higher risk of death resulting from excess adiposity may be attenuated by physical activity (PA). However, the theoretical number of deaths reduced by eliminating physical inactivity compared with overall and abdominal obesity remains unclear.Objective: We examined whether overall and abdominal adiposity modified the association between PA and all-cause mortality and estimated the population attributable fraction (PAF) and the years of life gained for these exposures.Design: This was a cohort study in 334,161 European men and women. The mean follow-up time was 12.4 y, corresponding to 4,154,915 person-years. Height, weight, and waist circumference (WC) were measured in the clinic. PA was assessed with a validated self-report instrument. The combined associations between PA, BMI, and WC with mortality were examined with Cox proportional hazards models, stratified by center and age group, and adjusted for sex, education, smoking, and alcohol intake. Center-specific PAF associated with inactivity, body mass index (BMI; in kg/m2) (>30), and WC (≥102 cm for men, ≥88 cm for women) were calculated and combined in random-effects meta-analysis. Life-tables analyses were used to estimate gains in life expectancy for the exposures.Results: Significant interactions (PA × BMI and PA × WC) were observed, so HRs were estimated within BMI and WC strata. The hazards of all-cause mortality were reduced by 16–30% in moderately inactive individuals compared with those categorized as inactive in different strata of BMI and WC. Avoiding all inactivity would theoretically reduce all-cause mortality by 7.35% (95% CI: 5.88%, 8.83%). Corresponding estimates for avoiding obesity (BMI >30) were 3.66% (95% CI: 2.30%, 5.01%). The estimates for avoiding high WC were similar to those for physical inactivity.Conclusion: The greatest reductions in mortality risk were observed between the 2 lowest activity groups across levels of general and abdominal adi
AU  - Ekelund,U
AU  - Ward,HA
AU  - Norat,T
AU  - Luan,J
AU  - May,AM
AU  - Weiderpass,E
AU  - Sharp,SJ
AU  - Overvad,K
AU  - Ostergaard,JN
AU  - TjOnneland,A
AU  - Johnsen,NF
AU  - Mesrine,S
AU  - Foamier,A
AU  - Fagherazzi,G
AU  - Trichopoulou,A
AU  - Lagiou,P
AU  - Trichopoulos,D
AU  - Li,K
AU  - Kaaks,R
AU  - Ferrari,P
AU  - Licaj,I
AU  - Jenab,M
AU  - Bergmann,M
AU  - Boeing,H
AU  - Palli,D
AU  - Sieri,S
AU  - Panico,S
AU  - Tumino,R
AU  - Vineis,P
AU  - Peeters,PH
AU  - Monnikhof,E
AU  - Bueno-de-Mesquita,HB
AU  - Ramon,Quiros J
AU  - Agudo,A
AU  - Sanchez,M-J
AU  - Maria,Huerta J
AU  - Ardanaz,E
AU  - Arriola,L
AU  - Hedblad,B
AU  - Wirfalt,E
AU  - Sand,M
AU  - Johansson,M
AU  - Key,TJ
AU  - Travis,RC
AU  - Khaw,K-T
AU  - Brage,S
AU  - Wareham,NJ
AU  - Riboli,E
DO  - 10.3945/ajcn.114.100065
EP  - 621
PY  - 2015///
SN  - 0002-9165
SP  - 613
TI  - Physical activity and all-cause mortality across levels of overall and abdominal adiposity in European men and women: the European Prospective Investigation into Cancer and Nutrition Study (EPIC)
T2  - American Journal of Clinical Nutrition
UR  - http://dx.doi.org/10.3945/ajcn.114.100065
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000350538800026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/48775
VL  - 101
ER  - 

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