@article{Aune:2016:10.1136/bmj.i2716,
author = {Aune, D and Keum, N and Giovannucci, E and Fadnes, LT and Boffetta, P and Greenwood, DC and Tonstad, S and Vatten, LJ and Riboli, E and Norat, T},
doi = {10.1136/bmj.i2716},
journal = {BMJ},
title = {Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: systematic review and dose-response meta-analysis of prospective studies},
url = {http://dx.doi.org/10.1136/bmj.i2716},
volume = {353},
year = {2016}
}

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TY  - JOUR
AB  - Objective To quantify the dose-response relation between consumption of whole grain and specific types of grains and the risk of cardiovascular disease, total cancer, and all cause and cause specific mortality.Data sources PubMed and Embase searched up to 3 April 2016.Study selection Prospective studies reporting adjusted relative risk estimates for the association between intake of whole grains or specific types of grains and cardiovascular disease, total cancer, all cause or cause specific mortality.Data synthesis Summary relative risks and 95% confidence intervals calculated with a random effects model.Results 45 studies (64 publications) were included. The summary relative risks per 90 g/day increase in whole grain intake (90 g is equivalent to three servings—for example, two slices of bread and one bowl of cereal or one and a half pieces of pita bread made from whole grains) was 0.81 (95% confidence interval 0.75 to 0.87; I2=9%, n=7 studies) for coronary heart disease, 0.88 (0.75 to 1.03; I2=56%, n=6) for stroke, and 0.78 (0.73 to 0.85; I2=40%, n=10) for cardiovascular disease, with similar results when studies were stratified by whether the outcome was incidence or mortality. The relative risks for morality were 0.85 (0.80 to 0.91; I2=37%, n=6) for total cancer, 0.83 (0.77 to 0.90; I2=83%, n=11) for all causes, 0.78 (0.70 to 0.87; I2=0%, n=4) for respiratory disease, 0.49 (0.23 to 1.05; I2=85%, n=4) for diabetes, 0.74 (0.56 to 0.96; I2=0%, n=3) for infectious diseases, 1.15 (0.66 to 2.02; I2=79%, n=2) for diseases of the nervous system disease, and 0.78 (0.75 to 0.82; I2=0%, n=5) for all non-cardiovascular, non-cancer causes. Reductions in risk were observed up to an intake of 210-225 g/day (seven to seven and a half servings per day) for most of the outcomes. Intakes of specific types of whole grains including whole grain bread, whole grain breakfast cereals, and added bran, as well as total bread and total breakfast cereals were also associated with re
AU  - Aune,D
AU  - Keum,N
AU  - Giovannucci,E
AU  - Fadnes,LT
AU  - Boffetta,P
AU  - Greenwood,DC
AU  - Tonstad,S
AU  - Vatten,LJ
AU  - Riboli,E
AU  - Norat,T
DO  - 10.1136/bmj.i2716
PY  - 2016///
SN  - 0959-8138
TI  - Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: systematic review and dose-response meta-analysis of prospective studies
T2  - BMJ
UR  - http://dx.doi.org/10.1136/bmj.i2716
UR  - http://hdl.handle.net/10044/1/32310
VL  - 353
ER  - 

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