@article{Arnes:2016:10.1101/gad.273821.115,
author = {Arnes, L and Akerman, I and Balderes, DA and Ferrer, J and Sussel, L},
doi = {10.1101/gad.273821.115},
journal = {Genes & Development},
pages = {502--507},
title = {βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function},
url = {http://dx.doi.org/10.1101/gad.273821.115},
volume = {30},
year = {2016}
}

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TY  - JOUR
AB  - Pancreatic β cells are responsible for maintaining glucose homeostasis; their absence or malfunction results in diabetes mellitus. Although there is evidence that long noncoding RNAs (lncRNAs) play important roles in development and disease, none have been investigated in vivo in the context of pancreas development. In this study, we demonstrate that βlinc1 (β-cell long intergenic noncoding RNA 1), a conserved lncRNA, is necessary for the specification and function of insulin-producing β cells through the coordinated regulation of a number of islet-specific transcription factors located in the genomic vicinity of βlinc1. Furthermore, deletion of βlinc1 results in defective islet development and disruption of glucose homeostasis in adult mice.
AU  - Arnes,L
AU  - Akerman,I
AU  - Balderes,DA
AU  - Ferrer,J
AU  - Sussel,L
DO  - 10.1101/gad.273821.115
EP  - 507
PY  - 2016///
SN  - 1549-5477
SP  - 502
TI  - βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function
T2  - Genes & Development
UR  - http://dx.doi.org/10.1101/gad.273821.115
UR  - http://hdl.handle.net/10044/1/34479
VL  - 30
ER  - 

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