Publications
105 results found
Mallarino R, Campas O, Fritz JA, et al., 2012, Closely related bird species demonstrate flexibility between beak morphology and underlying developmental programs, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 109, Pages: 16222-16227, ISSN: 0027-8424
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- Citations: 69
Bhullar B-AS, Marugan-Lobon J, Racimo F, et al., 2012, Birds have paedomorphic dinosaur skulls, NATURE, Vol: 487, Pages: 223-226, ISSN: 0028-0836
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- Citations: 161
Sanger TJ, Mahler DL, Abzhanov A, et al., 2012, ROLES FOR MODULARITY AND CONSTRAINT IN THE EVOLUTION OF CRANIAL DIVERSITY AMONG ANOLIS LIZARDS, EVOLUTION, Vol: 66, Pages: 1525-1542, ISSN: 0014-3820
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- Citations: 103
Sanger TJ, Seav SM, Losos JB, et al., 2012, Evolution and Development of Sexual Skull Dimorphism among Anolis lizards, Annual Meeting of the Society-for-Integrative-and-Comparative-Biology (SICB), Publisher: OXFORD UNIV PRESS INC, Pages: E153-E153, ISSN: 1540-7063
Abzhanov A, 2012, Pecking at the Origin of Morphological Diversity: Insights from Darwin's Finches and Other Birds, Annual Meeting of the Society-for-Integrative-and-Comparative-Biology (SICB), Publisher: OXFORD UNIV PRESS INC, Pages: E1-E1, ISSN: 1540-7063
St John JA, Braun EL, Isberg SR, et al., 2012, Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes, Genome Biology, Vol: 13, ISSN: 1474-760X
Mallarino R, Abzhanov A, 2012, Paths Less Traveled: Evo-Devo Approaches to Investigating Animal Morphological Evolution, ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 28, Vol: 28, Pages: 743-763, ISSN: 1081-0706
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- Citations: 29
Kusumi K, Kulathinal RJ, Abzhanov A, et al., 2011, Developing a community-based genetic nomenclature for anole lizards, BMC Genomics, Vol: 12, ISSN: 1471-2164
BACKGROUND: Comparative studies of amniotes have been hindered by a dearth of reptilian molecular sequences. With the genomic assembly of the green anole, Anolis carolinensis available, non-avian reptilian genes can now be compared to mammalian, avian, and amphibian homologs. Furthermore, with more than 350 extant species in the genus Anolis, anoles are an unparalleled example of tetrapod genetic diversity and divergence. As an important ecological, genetic and now genomic reference, it is imperative to develop a standardized Anolis gene nomenclature alongside associated vocabularies and other useful metrics. RESULTS: Here we report the formation of the Anolis Gene Nomenclature Committee (AGNC) and propose a standardized evolutionary characterization code that will help researchers to define gene orthology and paralogy with tetrapod homologs, provide a system for naming novel genes in Anolis and other reptiles, furnish abbreviations to facilitate comparative studies among the Anolis species and related iguanid squamates, and classify the geographical origins of Anolis subpopulations. CONCLUSIONS: This report has been generated in close consultation with members of the Anolis and genomic research communities, and using public database resources including NCBI and Ensembl. Updates will continue to be regularly posted to new research community websites such as lizardbase. We anticipate that this standardized gene nomenclature will facilitate the accessibility of reptilian sequences for comparative studies among tetrapods and will further serve as a template for other communities in their sequencing and annotation initiatives.
Mallarino R, Grant PR, Grant BR, et al., 2011, Two developmental modules establish 3D beak-shape variation in Darwin's finches, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 108, Pages: 4057-4062, ISSN: 0027-8424
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- Citations: 143
Mansfield JH, Abzhanov A, 2010, Hox Expression in the American Alligator and Evolution of Archosaurian Axial Patterning, JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION, Vol: 314B, Pages: 629-644, ISSN: 1552-5007
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- Citations: 26
Abzhanov A, 2010, Darwin's Galapagos finches in modern biology, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 365, Pages: 1001-1007, ISSN: 0962-8436
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- Citations: 15
Campas O, Mallarino R, Herrel A, et al., 2010, Scaling and shear transformations capture beak shape variation in Darwin's finches, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 107, Pages: 3356-3360, ISSN: 0027-8424
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- Citations: 51
Clabaut C, Herrel A, Sanger TJ, et al., 2009, Development of beak polymorphism in the African seedcracker, <i>Pyrenestes ostrinus</i>, EVOLUTION & DEVELOPMENT, Vol: 11, Pages: 636-646, ISSN: 1520-541X
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- Citations: 24
Abzhanov A, 2009, Pecking at the origin of vertebrate diversity: Insights from the beak of the Finch, 16th Annual Conference of the International-Society-of-Development-Biologists, Publisher: ELSEVIER SCIENCE BV, Pages: S15-S15, ISSN: 0925-4773
Abzhanov A, 2009, Pecking at the origin of vertebrate diversity: insights from the beak of the finch, Publisher: FEDERATION AMER SOC EXP BIOL, ISSN: 0892-6638
Abzhanov A, 2009, In situ hybridization analysis of embryonic beak tissue from Darwin's finches., Cold Spring Harb Protoc, Vol: 2009
Abzhanov A, 2009, Collection of embryos from Darwin's finches (Thraupidae, Passeriformes)., Cold Spring Harb Protoc, Vol: 2009
Abzhanov A, 2009, Darwin's finches: analysis of beak morphological changes during evolution., Cold Spring Harb Protoc, Vol: 2009
Abzhanov A, 2009, Microarray analysis of embryonic beak mRNA from Darwin's finches., Cold Spring Harb Protoc, Vol: 2009
Abzhanov A, 2009, Pecking at the Origin of Vertebrate Diversity, Annual Meeting of the Society-for-Integrative-and-Comparative-Biology, Publisher: OXFORD UNIV PRESS INC, Pages: E1-E1, ISSN: 1540-7063
Sanger TJ, Mahler DL, Losos JB, et al., 2009, The evolution of developmental patterns in the Anolis skeleton, Annual Meeting of the Society-for-Integrative-and-Comparative-Biology, Publisher: OXFORD UNIV PRESS INC, Pages: E150-E150, ISSN: 1540-7063
Fu S, Zhao H, Shi J, et al., 2008, Peripheral arterial occlusive disease: Global gene expression analyses suggest a major role for immune and inflammatory responses, BMC Genomics, Vol: 9, ISSN: 1471-2164
BACKGROUND: Peripheral arterial disease (PAD), a major manifestation of atherosclerosis, is associated with significant cardiovascular morbidity, limb loss and death. However, mechanisms underlying the genesis and progression of the disease are far from clear. Genome-wide gene expression profiling of clinical samples may represent an effective approach to gain relevant information. RESULTS: After histological classification, a total of 30 femoral artery samples, including 11 intermediate lesions, 14 advanced lesions and 5 normal femoral arteries, were profiled using Affymetrix microarray platform. Following real-time RT-PCR validation, different algorithms of gene selection and clustering were applied to identify differentially expressed genes. Under a stringent cutoff, i.e., a false discovery rate (FDR) <0.5%, we found 366 genes were differentially regulated in intermediate lesions and 447 in advanced lesions. Of these, 116 genes were overlapped between intermediate and advanced lesions, including 68 up-regulated genes and 48 down-regulated ones. In these differentially regulated genes, immune/inflammatory genes were significantly up-regulated in different stages of PAD, (85/230 in intermediate lesions, 37/172 in advanced lesions). Through literature mining and pathway analysis using different databases such as Gene Ontology (GO), and the Kyoto Encyclopedia of Gene and Genomics (KEGG), genes involved in immune/inflammatory responses were significantly enriched in up-regulated genes at different stages of PAD(p < 0.05), revealing a significant correlation between immune/inflammatory responses and disease progression. Moreover, immune-related pathways such as Toll-like receptor signaling and natural killer cell mediated cytotoxicity were particularly enriched in intermediate and advanced lesions (P < 0.05), highlighting their pathogenic significance during disease progression. CONCLUSION: Lines of evidence revealed in this study not only support previous hyp
Abzhanov A, Extavour CG, Groover A, et al., 2008, Are we there yet? Tracking the development of new model systems, TRENDS IN GENETICS, Vol: 24, Pages: 353-360, ISSN: 0168-9525
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- Citations: 75
Abzhanov A, Cordero DR, Sen J, et al., 2007, Cross-regulatory interactions between Fgf8 and Shh in the avian frontonasal prominence., Congenit Anom (Kyoto), Vol: 47, Pages: 136-148, ISSN: 0914-3505
The frontonasal prominence of the developing avian embryo contains an organizing center, defined by juxtaposition of the Sonic hedgehog (Shh) and Fibroblast growth factor 8 (Fgf8) expression domains. This molecular interface presages any detectable growth of the frontonasal prominence, and experiments involving transplantation of this boundary epithelium have demonstrated it is a source of dorsal-ventral and rostral-caudal patterning information for the neural crest-derived mesenchyme of the upper beak. We explored the ontogeny of this organizing center by mapping the expression domains of both genes and their receptors and downstream targets. We tested the extent to which Shh and Fgf8 regulate each other's expression in this frontonasal organizer by either blocking or ectopically activating these pathways. Our experiments revealed mutual antagonism between the two molecules, which aids in establishing and maintaining a molecular boundary that subsequently influences patterning and growth of the middle and upper face.
Abzhanov A, Rodda SJ, McMahon AP, et al., 2007, Regulation of skeletogenic differentiation in cranial dermal bone, DEVELOPMENT, Vol: 134, Pages: 3133-3144, ISSN: 0950-1991
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- Citations: 163
Abzhanov A, 2006, Pecking at the origin of avian morphological variation, Publisher: OXFORD UNIV PRESS INC, Pages: E1-E1, ISSN: 1540-7063
Abzhanov A, Kuo WP, Hartmann C, et al., 2006, The calmodulin pathway and evolution of elongated beak morphology in Darwin's finches, NATURE, Vol: 442, Pages: 563-567, ISSN: 0028-0836
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- Citations: 412
Grant PR, Grant BR, Abzhanov A, 2006, A developing paradigm for the development of bird beaks, BIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY, Vol: 88, Pages: 17-22, ISSN: 0024-4066
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- Citations: 25
Abzhanov A, Protas M, Grant BR, et al., 2004, <i>Bmp4</i> and morphological variation of beaks in Darwin's finches, SCIENCE, Vol: 305, Pages: 1462-1465, ISSN: 0036-8075
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- Citations: 564
Abzhanov A, Tabin CJ, 2004, <i>Shh</i> and <i>Fgf8</i> act synergistically to drive cartilage outgrowth during cranial development, DEVELOPMENTAL BIOLOGY, Vol: 273, Pages: 134-148, ISSN: 0012-1606
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- Citations: 120
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