Imperial College London
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Mr Ahmed R. Ahmed PhD FRCS

Faculty of Medicine, Department of Surgery & Cancer

Clinical Reader in Metabolic Surgery
 
 
 
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Contact

 

+44 (0)20 8846 1081a.ahmed07

 
 
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Location

 

Charing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{McGlone:2021:10.1152/ajpendo.00580.2020,
author = {McGlone, ER and Malallah, K and Cuenco, J and Wewer, Albrechtsen NJ and Holst, JJ and Vincent, RP and Ling, C and Khan, OA and Verma, S and Ahmed, AR and Walters, JR and Khoo, B and Bloom, SR and Tan, TM-M},
doi = {10.1152/ajpendo.00580.2020},
journal = {Am J Physiol Endocrinol Metab},
title = {DIFFERENTIAL EFFECTS OF BILE ACIDS ON THE POST-PRANDIAL SECRETION OF GUT HORMONES: a randomised crossover study.},
url = {http://dx.doi.org/10.1152/ajpendo.00580.2020},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AIMS Bile acids (BA) regulate post-prandial metabolism directly and indirectly by affecting the secretion of gut hormones like glucagon-like peptide-1 (GLP-1). The post-prandial effects of BA on the secretion of other metabolically active hormones are not well understood. The objective of this study was to investigate the effect of oral ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) on post-prandial secretion of GLP-1, oxyntomodulin (OXM), peptide YY (PYY), glucose-dependent insulinotropic peptide (GIP), glucagon and ghrelin. METHODS Twelve healthy volunteers underwent a mixed meal test 60 minutes after ingestion of UDCA (12-16 mg/kg), CDCA (13-16 mg/kg) or no BA in a randomised cross-over study. Glucose, insulin, GLP-1, OXM, PYY, GIP, glucagon, ghrelin and fibroblast growth factor 19 were measured prior to BA administration at -60, 0 (just prior to mixed meal) and 15, 30, 60, 120, 180 and 240 minutes after the meal. RESULTS UDCA and CDCA provoked differential gut hormone responses: UDCA did not have any significant effects, but CDCA provoked significant increases in GLP-1 and OXM and a profound reduction in GIP. CDCA increased fasting GLP-1 and OXM secretion in parallel with an increase in insulin. On the other hand, CDCA reduced post-prandial secretion of GIP, with an associated reduction in post-prandial insulin secretion. CONCLUSIONS Exogenous CDCA can exert multiple salutary effects on the secretion of gut hormones; if these effects are confirmedin obesity and type 2 diabetes, CDCA may be a potential therapy for these conditions.
AU  - McGlone,ER
AU  - Malallah,K
AU  - Cuenco,J
AU  - Wewer,Albrechtsen NJ
AU  - Holst,JJ
AU  - Vincent,RP
AU  - Ling,C
AU  - Khan,OA
AU  - Verma,S
AU  - Ahmed,AR
AU  - Walters,JR
AU  - Khoo,B
AU  - Bloom,SR
AU  - Tan,TM-M
DO  - 10.1152/ajpendo.00580.2020
PY  - 2021///
TI  - DIFFERENTIAL EFFECTS OF BILE ACIDS ON THE POST-PRANDIAL SECRETION OF GUT HORMONES: a randomised crossover study.
T2  - Am J Physiol Endocrinol Metab
UR  - http://dx.doi.org/10.1152/ajpendo.00580.2020
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33459181
ER  -
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