Imperial College London

ProfessorAlanArmstrong

Faculty of Natural SciencesDepartment of Chemistry

Professor of Organic Synthesis
 
 
 
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Contact

 

+44 (0)20 7594 5876a.armstrong

 
 
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Location

 

501EMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bures:2011:10.1021/ja203660r,
author = {Bures, J and Armstrong, A and Blackmond, DG},
doi = {10.1021/ja203660r},
journal = {JOURNAL OF THE AMERICAN CHEMICAL SOCIETY},
pages = {(8822--8825)--(8822--8825)},
title = {Mechanistic Rationalization of Organocatalyzed Conjugate Addition of Linear Aldehydes to Nitro-olefins},
url = {http://dx.doi.org/10.1021/ja203660r},
volume = {133},
year = {2011}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Kinetic studies of the conjugate addition of propanal to nitrostyrene catalyzed by diarylprolinol ethers reveal that formation of the product iminium species is rate-determining and is promoted by both the reaction product and acid additives. The beneficial role of a dominant cyclobutane intermediate in maintaining high stereoselectivity is highlighted. This mechanistic understanding led to the design of highly productive reaction protocols.
AU - Bures,J
AU - Armstrong,A
AU - Blackmond,DG
DO - 10.1021/ja203660r
EP - 8825
PY - 2011///
SN - 0002-7863
SP - 8822
TI - Mechanistic Rationalization of Organocatalyzed Conjugate Addition of Linear Aldehydes to Nitro-olefins
T2 - JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
UR - http://dx.doi.org/10.1021/ja203660r
VL - 133
ER -