Imperial College London
Alternate

Dr Antonio J Berlanga-Taylor

Faculty of Medicine, School of Public Health

Honorary Senior Research Fellow
 
 
 
//

Contact

 

a.berlanga

 
 
//

Location

 

47 Praed StreetSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Romo-García:2019:10.1016/j.gene.2019.144081,
author = {Romo-García, MF and Bastian, Y and Zapata-Zuñiga, M and Macías-Segura, N and Castillo-Ortiz, JD and Lara-Ramírez, EE and Fernández-Ruíz, JC and Berlanga-Taylor, AJ and González-Amaro, R and Ramos-Remus, C and Enciso-Moreno, JA and Castañeda-Delgado, JE},
doi = {10.1016/j.gene.2019.144081},
journal = {Gene},
title = {Identification of putative miRNA biomarkers in early rheumatoid arthritis by genome-wide microarray profiling: A pilot study},
url = {http://dx.doi.org/10.1016/j.gene.2019.144081},
volume = {720},
year = {2019}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Despite the existing research, the etiology of rheumatoid arthritis (RA), an autoimmune disease remains poorly understood with early and accurate diagnosis difficult to achieve. MicroRNAs (miRNAs) play an important role in biological processes as modulators of transcription and translation. Previous studies have demonstrated a downregulation of several genes in early RA stages and in addition, miRNAs may serve as early biomarkers of subclinical changes in early RA.When comparing the four groups (ANOVA P<0.01, fold change>4), we found 253 differentially expressed miRNAs. Of these, 97 miRNAs were identified as overexpressed in early rheumatoid arthritis. The validation of miRNA microarray expression was performed in a set by RT-qPCR and showed strong agreement with microarray expression data. The putative targets of overexpressed microRNAs in early RA were significantly enriched in apoptosis, tolerance loss and Wnt pathways. Moreover, ROC analysis showed values of AUC 0.76 and P<0.05 for miR361-5p, identifying this miRNA as a potential biomarker of disease.We identified specific microRNAs associated with early rheumatoid arthritis and proposed them as early biomarkers of disease. Our results provide novel insight into immune disease physiopathology and describe unreported microRNAs in RA with potential for clinical use.
AU  - Romo-García,MF
AU  - Bastian,Y
AU  - Zapata-Zuñiga,M
AU  - Macías-Segura,N
AU  - Castillo-Ortiz,JD
AU  - Lara-Ramírez,EE
AU  - Fernández-Ruíz,JC
AU  - Berlanga-Taylor,AJ
AU  - González-Amaro,R
AU  - Ramos-Remus,C
AU  - Enciso-Moreno,JA
AU  - Castañeda-Delgado,JE
DO  - 10.1016/j.gene.2019.144081
PY  - 2019///
SN  - 0378-1119
TI  - Identification of putative miRNA biomarkers in early rheumatoid arthritis by genome-wide microarray profiling: A pilot study
T2  - Gene
UR  - http://dx.doi.org/10.1016/j.gene.2019.144081
UR  - https://www.sciencedirect.com/science/article/pii/S0378111919307401?via%3Dihub
UR  - http://hdl.handle.net/10044/1/73068
VL  - 720
ER  -
Download