Imperial College London
Alternate

Professor Anil Anthony Bharath

Faculty of Engineering, Department of Bioengineering

Academic Director (Singapore)
 
 
 
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Contact

 

+44 (0)20 7594 5463a.bharath Website

 
 
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Location

 

4.12Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bond:2011:10.1161/ATVBAHA.110.219683,
author = {Bond, AR and Iftikhar, S and Bharath, AA and Weinberg, PD},
doi = {10.1161/ATVBAHA.110.219683},
journal = {Arterioscler Thromb Vasc Biol},
pages = {ATVBAHA.110.219683--ATVBAHA.110.219683},
title = {Morphological Evidence for a Change in the Pattern of Aortic Wall Shear Stress With Age},
url = {http://dx.doi.org/10.1161/ATVBAHA.110.219683},
year = {2011}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective–The distribution of atherosclerosis around branch sites changes with age in human and rabbit aortas. We tested whether that reflects a change in the pattern of wall shear stress by examining shear-dependent morphological features of endothelial cells.  Methods and Results–Endothelial cells and their nuclei align and elongate with applied shear. These parameters were examined in the descending thoracic aorta of immature and mature rabbits. The use of Hautchen preparations, fluorescent stains, and automated image analysis allowed nuclear morphology to be mapped reliably at high resolution over large areas. Cells and their nuclei were most elongated downstream of branch ostia in immature aortas but upstream of them in mature aortas. Elongation was generally greater in mature animals, and nuclei aligned toward the ostia more in these animals, consistent with a greater flow into the branch. Morphology away from branches was indicative of helical flow in the aorta, with greatest shear on the dorsal wall, at both ages.  Conclusion–The data are consistent with age-related changes in the pattern of shear around aortic branches. Maps of nuclear elongation closely resembled maps of lesion frequency. The association was positive, implying that lesions occur at sites of high shear stress at both ages.
AU  - Bond,AR
AU  - Iftikhar,S
AU  - Bharath,AA
AU  - Weinberg,PD
DO  - 10.1161/ATVBAHA.110.219683
EP  - 219683
PY  - 2011///
SP  - 110
TI  - Morphological Evidence for a Change in the Pattern of Aortic Wall Shear Stress With Age
T2  - Arterioscler Thromb Vasc Biol
UR  - http://dx.doi.org/10.1161/ATVBAHA.110.219683
UR  - http://atvb.ahajournals.org/cgi/content/abstract/ATVBAHA.110.219683v1
UR  - http://hdl.handle.net/10044/1/19277
ER  -
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