Imperial College London
Alternate

DrAndrewBlagborough

Faculty of Natural Sciences, Department of Life Sciences

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 5350a.blagborough

 
 
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Location

 

603Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sirignano:2021:10.1016/j.phytochem.2020.112632,
author = {Sirignano, C and Hammami, S and El, Mokni R and Blagborough, AM and Luciano, P and Rigano, D and Scafati, OT},
doi = {10.1016/j.phytochem.2020.112632},
journal = {Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology},
title = {Polyoxygenated germacranes from Daucus carota and their antimalarial transmission blocking activity},
url = {http://dx.doi.org/10.1016/j.phytochem.2020.112632},
volume = {183},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Chemical analysis of the aerial parts obtained from a Tunisian specimen of Daucus carota yielded to the isolation of six undescribed polyoxygenated germacranes and one elemanolide, along with one known metabolite. The stereostructures of the undescribed compounds were determined by extensive spectroscopic analysis including 1D and 2D NMR and HR-ESI-MS analysis. Due to their structural similarity with the Plasmodium transmission-blocking agent daucovirgolide G, the isolated metabolites were evaluated for their inhibitory activity on the development of Plasmodium early sporogonic stages. Three compounds proved to inhibit ookinete formation showing a good transmission blocking efficacy, but the low potency exhibited by these compounds when compared to daucovirgolide G further supports the observation that strict structural requirements do exist for the antimalarial activity of germacranolides.
AU  - Sirignano,C
AU  - Hammami,S
AU  - El,Mokni R
AU  - Blagborough,AM
AU  - Luciano,P
AU  - Rigano,D
AU  - Scafati,OT
DO  - 10.1016/j.phytochem.2020.112632
PY  - 2021///
SN  - 0031-9422
TI  - Polyoxygenated germacranes from Daucus carota and their antimalarial transmission blocking activity
T2  - Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology
UR  - http://dx.doi.org/10.1016/j.phytochem.2020.112632
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33360528
VL  - 183
ER  -
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