Imperial College London
Alternate

ProfessorAlexBlakemore

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 2156a.blakemore

 
 
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Location

 

Commonwealth Building, 6N2BHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Amin:2019:10.1101/838409,
author = {Amin, HA and Drenos, F and Blakemore, AI},
doi = {10.1101/838409},
title = {Variation at the Klotho gene locus does not affect cognitive function in up to 335,074 British Caucasians in the UK Biobank},
url = {http://dx.doi.org/10.1101/838409},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>The proportion of older adults in Western populations is increasing and there is, therefore, a need to define factors affecting maintenance of physical and cognitive health in old age. Variations in the Klotho (<jats:italic>KL</jats:italic>) gene, and specifically the <jats:italic>KL</jats:italic>-VS haplotype, have been identified by several authors as potentially influencing cognitive function and decline. We have attempted to verify the reported associations between <jats:italic>KL</jats:italic> variants, including the <jats:italic>KL</jats:italic>-VS haplotype, and cognitive function in up to 335,074 British Caucasian participants aged 40-79 years from the UK Biobank. We do not find evidence that <jats:italic>KL</jats:italic>-VS affects cognitive function or its decline with increasing age. We examined a further 244 <jats:italic>KL</jats:italic> variants and found that rs117650866 was associated with Prospective Memory, but could not replicate this in follow-up samples. In conclusion, there is insufficient evidence in the UK Biobank to support the concept that <jats:italic>KL</jats:italic> variants affect cognitive function or its rate of decline.</jats:p>
AU  - Amin,HA
AU  - Drenos,F
AU  - Blakemore,AI
DO  - 10.1101/838409
PY  - 2019///
TI  - Variation at the Klotho gene locus does not affect cognitive function in up to 335,074 British Caucasians in the UK Biobank
UR  - http://dx.doi.org/10.1101/838409
ER  -
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