Imperial College London

Professor Aldo R. Boccaccini

Faculty of EngineeringDepartment of Materials

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 6731a.boccaccini

 
 
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Location

 

210Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

1189 results found

Frank MA, Meltzer C, Braunschweig B, Peukert W, Boccaccini AR, Virtanen Set al., 2017, Functionalization of steel surfaces with organic acids: Influence on wetting and corrosion behavior, APPLIED SURFACE SCIENCE, Vol: 404, Pages: 326-333, ISSN: 0169-4332

Journal article

Kaya S, Boccaccini AR, 2017, Electrophoretic deposition of zein coatings, JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH, Vol: 14, Pages: 683-689, ISSN: 1547-0091

Journal article

Sarker B, Singh R, Zehnder T, Forgber T, Alexiou C, Cicha I, Detsch R, Boccaccini ARet al., 2017, Macromolecular interactions in alginate-gelatin hydrogels regulate the behavior of human fibroblasts, JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, Vol: 32, Pages: 309-324, ISSN: 0883-9115

Journal article

Juhasz-Bortuzzo JA, Myszka B, Silva R, Boccaccini ARet al., 2017, Sonosynthesis of Vaterite-Type Calcium Carbonate, CRYSTAL GROWTH & DESIGN, Vol: 17, Pages: 2351-2356, ISSN: 1528-7483

Journal article

Cordero-Arias L, Boccaccini AR, 2017, Electrophoretic deposition of chondroitin sulfate-chitosan/bioactive glass composite coatings with multilayer design, SURFACE & COATINGS TECHNOLOGY, Vol: 315, Pages: 417-425, ISSN: 0257-8972

Journal article

Heise S, Hoehlinger M, Torres Hernandez Y, Pavon Palacio JJ, Rodriquez Ortiz JA, Wagener V, Virtanen S, Boccaccini ARet al., 2017, Electrophoretic deposition and characterization of chitosan/bioactive glass composite coatings on Mg alloy substrates, ELECTROCHIMICA ACTA, Vol: 232, Pages: 456-464, ISSN: 0013-4686

Journal article

Boccardi E, Ciraldo FE, Boccaccini AR, 2017, Bioactive glass-ceramic scaffolds: Processing and properties, MRS BULLETIN, Vol: 42, Pages: 226-232, ISSN: 0883-7694

Journal article

Bejarano J, Detsch R, Boccaccini AR, Palza Het al., 2017, PDLLA scaffolds with Cu- and Zn-doped bioactive glasses having multifunctional properties for bone regeneration, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol: 105, Pages: 746-756, ISSN: 1549-3296

Journal article

Dippold D, Cai A, Hardt M, Boccaccini AR, Horch R, Beier JP, Schubert DWet al., 2017, Novel approach towards aligned PCL-Collagen nanofibrous constructs from a benign solvent system, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Vol: 72, Pages: 278-283, ISSN: 0928-4931

Journal article

Witt R, Weigand A, Boos AM, Cai A, Dippold D, Boccaccini AR, Schubert DW, Hardt M, Lange C, Arkudas A, Horch RE, Beier JPet al., 2017, Mesenchymal stem cells and myoblast differentiation under HGF and IGF-1 stimulation for 3D skeletal muscle tissue engineering, BMC Cell Biology, Vol: 18, ISSN: 1471-2121

BackgroundVolumetric muscle loss caused by trauma or after tumour surgery exceeds the natural regeneration capacity of skeletal muscle. Hence, the future goal of tissue engineering (TE) is the replacement and repair of lost muscle tissue by newly generating skeletal muscle combining different cell sources, such as myoblasts and mesenchymal stem cells (MSCs), within a three-dimensional matrix. Latest research showed that seeding skeletal muscle cells on aligned constructs enhance the formation of myotubes as well as cell alignment and may provide a further step towards the clinical application of engineered skeletal muscle.In this study the myogenic differentiation potential of MSCs upon co-cultivation with myoblasts and under stimulation with hepatocyte growth factor (HGF) and insulin-like growth factor-1 (IGF-1) was evaluated. We further analysed the behaviour of MSC-myoblast co-cultures in different 3D matrices.ResultsPrimary rat myoblasts and rat MSCs were mono- and co-cultivated for 2, 7 or 14 days. The effect of different concentrations of HGF and IGF-1 alone, as well as in combination, on myogenic differentiation was analysed using microscopy, multicolour flow cytometry and real-time PCR. Furthermore, the influence of different three-dimensional culture models, such as fibrin, fibrin-collagen-I gels and parallel aligned electrospun poly-ε-caprolacton collagen-I nanofibers, on myogenic differentiation was analysed. MSCs could be successfully differentiated into the myogenic lineage both in mono- and in co-cultures independent of HGF and IGF-1 stimulation by expressing desmin, myocyte enhancer factor 2, myosin heavy chain 2 and alpha-sarcomeric actinin. An increased expression of different myogenic key markers could be observed under HGF and IGF-1 stimulation. Even though, stimulation with HGF/IGF-1 does not seem essential for sufficient myogenic differentiation. Three-dimensional cultivation in fibrin-collagen-I gels induced higher levels of myogenic di

Journal article

Yazdimamaghani M, Razavi M, Vashaee D, Moharamzadeh K, Boccaccini AR, Tayebi Let al., 2017, Porous magnesium-based scaffolds for tissue engineering, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Vol: 71, Pages: 1253-1266, ISSN: 0928-4931

Journal article

Mesquita-Guimaraes J, Leite MA, Souza JCM, Henriques B, Silva FS, Hotza D, Boccaccini AR, Fredel MCet al., 2017, Processing and strengthening of 58S bioactive glass-infiltrated titania scaffolds, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol: 105, Pages: 590-600, ISSN: 1549-3296

Journal article

Galarraga-Vinueza ME, Mesquita-Guimaraes J, Magini RS, Souza JCM, Fredel MC, Boccaccini ARet al., 2017, Anti-biofilm properties of bioactive glasses embedding organic active compounds, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol: 105, Pages: 672-679, ISSN: 1549-3296

Journal article

Zheng K, Dai X, Lu M, Hueser N, Taccardi N, Boccaccini ARet al., 2017, Synthesis of copper-containing bioactive glass nanoparticles using a modified Stober method for biomedical applications, COLLOIDS AND SURFACES B-BIOINTERFACES, Vol: 150, Pages: 159-167, ISSN: 0927-7765

Journal article

Nerantzaki M, Koliakou I, Kaloyianni MG, Koumentakou I, Siska E, Diamanti E, Karakassides MA, Boccaccini AR, Bikiaris DNet al., 2017, A biomimetic approach for enhancing adhesion and osteogenic differentiation of adipose-derived stem cells on poly(butylene succinate) composites with bioactive ceramics and glasses, EUROPEAN POLYMER JOURNAL, Vol: 87, Pages: 159-173, ISSN: 0014-3057

Journal article

Souza MT, Tansaz S, Zanotto ED, Boccaccini ARet al., 2017, Bioactive glass fiber-reinforced PGS matrix composites for cartilage regeneration, Materials, Vol: 10, ISSN: 1996-1944

Poly(glycerol sebacate) (PGS) is an elastomeric polymer which is attracting increasing interest for biomedical applications, including cartilage regeneration. However, its limited mechanical properties and possible negative effects of its degradation byproducts restrict PGS for in vivo application. In this study, a novel PGS–bioactive glass fiber (F18)-reinforced composite was developed and characterized. PGS-based reinforced scaffolds were fabricated via salt leaching and characterized regarding their mechanical properties, degradation, and bioactivity in contact with simulated body fluid. Results indicated that the incorporation of silicate-based bioactive glass fibers could double the composite tensile strength, tailor the polymer degradability, and improve the scaffold bioactivity.

Journal article

Niklaus L, Tansaz S, Dakhil H, Weber KT, Proschel M, Lang M, Kostrzewa M, Coto PB, Detsch R, Sonnewald U, Wierschem A, Boccaccini AR, Costa RDet al., 2017, Micropatterned Down-Converting Coating for White Bio-Hybrid Light-Emitting Diodes, ADVANCED FUNCTIONAL MATERIALS, Vol: 27, ISSN: 1616-301X

Journal article

Nerantzaki MC, Koliakou IG, Kaloyianni MG, Terzopoulou ZN, Siska EK, Karakassides MA, Boccaccini AR, Bikiaris DNet al., 2017, New N-(2-carboxybenzyl)chitosan composite scaffolds containing nanoTiO(2) or bioactive glass with enhanced cell proliferation for bone-tissue engineering applications, INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, Vol: 66, Pages: 71-81, ISSN: 0091-4037

Journal article

Ramskogler C, Cordero L, Warchomicka F, Boccaccini AR, Sommitsch Cet al., 2017, Biocompatible ceramic-biopolymer coatings obtained by electrophoretic deposition on electron beam structured titanium alloy surfaces, Pages: 1552-1557, ISSN: 0255-5476

© 2017 Trans Tech Publications, Switzerland. An area of major interest in biomedical engineering is currently the development of improved materials for medical implants. Research efforts are being focused on the investigation of surface modification methods for metallic prostheses due to the fundamental bioinert character of these materials and the possible ion release from their surfaces, which could potentially induce the interfacial loosening of devices after implantation. Electron beam (EB) structuring is a novel technique to control the surface topography in metals. Electrophoretic deposition (EPD) offers the feasibility to deposit at room temperature a variety of materials on conductive substrates from colloidal suspensions under electric fields. In this work single layers of chitosan composite coatings containing titania nanoparticles (n-TiO2) were deposit by EPD on electron beam (EB) structured Ti6Al4V titanium alloy. Surface structures were designed following different criteria in order to develop specific topography on the Ti6Al4V substrate. n-TiO2 particles were used as a model particle in order to demonstrate the versatility of the proposed technique for achieving homogenous chitosan based coatings on structured surfaces. A linear relation between EPD time and deposition yield on different patterned Ti6Al4V surfaces was determined under constant voltage conditions, obtaining homogeneous EPD coatings which replicate the 3D structure (pattern) of the substrate surface. The present results show that a combination of both techniques can be considered a promising surface modification approach for metallic implants, which should lead to improved interaction between the implant surface and the biological environment for orthopaedic applications.

Conference paper

Philippart A, Gomez-Cerezo N, Arcos D, Salinas AJ, Boccardi E, Vallet-Regi M, Boccaccini ARet al., 2017, Novel ion-doped mesoporous glasses for bone tissue engineering: Study of their structural characteristics influenced by the presence of phosphorous oxide, JOURNAL OF NON-CRYSTALLINE SOLIDS, Vol: 455, Pages: 90-97, ISSN: 0022-3093

Journal article

Hoppe A, Boccaccini AR, 2017, Chapter 16: Bioactive Glasses as Carriers of Therapeutic Ions and the Biological Implications, RSC Smart Materials, Pages: 362-392

© The Royal Society of Chemistry 2017. In the last few decades bioactive glasses (BGs) have been widely considered for bone tissue engineering applications due to their bioactivity and their osteogenic effects. The available scientific evidence suggests that ionic dissolution products (at a critical concentration) released during the degradation of the BG matrix induce osteogenic gene expression hence stimulating the bone regeneration process. Moreover, adding bioactive metallic ions (e.g. boron, copper, cobalt, lithium silver, zinc and strontium) to silicate as well as to phosphate and borate glasses has emerged as a promising route to develop novel BG formulations with specific therapeutic functionalities, including antibacterial, angiogenic, osteogenic and wound healing. The degradation behaviour of BGs can be tailored by adjusting the glass chemistry, making these biomaterials suitable carrier systems for controlled therapeutic ion release. This book chapter summarizes the fundamental aspects of the effect of ionic dissolution products released from BGs on osteogenesis and angiogenesis, also discussing novel BG compositions containing inorganic therapeutic agents. In vitro cellular as well as in vivo responses to specific therapeutic ions are discussed.

Book chapter

Naseri S, Boccaccini AR, Nazhat SN, 2017, Chapter 10: Bioactive Glass Particulate-incorporated Polymer Composites, RSC Smart Materials, Pages: 236-256

© The Royal Society of Chemistry 2017. Bioactive glasses can potentially be used in combination with polymers in order to create a new complex of enhanced bioactivity, biocompatibility, and mechanical and degradation properties for biomedical applications. There are various processing routes to fabricate particulate bioactive glass fillers composites (dense or porous). Each fabrication route has its own advantages and disadvantages, and the best fabrication route is determined depending on the materials used and the desired final application. In this chapter, the main particulate bioactive glass-incorporated polymer composite fabrication techniques are presented, along with their associated pros and cons. Additionally, the properties of the various composites for tissue engineering and biomedical applications are discussed.

Book chapter

Boccaccini AR, Brauer DS, Hupa L, 2017, Preface

Book

Rai R, Roether JA, Knowles JC, Mordan N, Salih V, Locke IC, Gordge MP, McCormick A, Mohn D, Stark WJ, Keshavarz T, Boccaccini AR, Roy Iet al., 2017, Highly elastomeric poly(3-hydroxyoctanoate) based natural polymer composite for enhanced keratinocyte regeneration, INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, Vol: 66, Pages: 326-335, ISSN: 0091-4037

Journal article

Miguez-Pacheco V, Gorustovich AA, Boccaccini AR, Roether JAet al., 2017, Chapter 15: Bioactive Glasses for Soft Tissue Engineering Applications, RSC Smart Materials, Pages: 336-361

© The Royal Society of Chemistry 2017. In the last few years the usage of bioactive glasses as scaffolds for soft tissue engineering has been investigated more thoroughly. The reason for the boost in interest is the attractive properties bioactive glasses offer, including bioactivity as well as antibacterial, angiogenic and hemostatic properties. So far, most research efforts have focused on applications for repairing skin and nerve tissue although there have been interesting developments in other fields including lung and intestine, which could potentially benefit a large group of patients. Three review articles on this topic have been published, so this chapter will mainly focus on the latest relevant findings. A great number of patents have been registered for the use of bioactive glass for hard tissue engineering. Recently, however, patents have been filed detailing the use of bioactive glass for soft tissue engineering applications which open the way to marketing bioactive glasses for soft tissue repair. The angiogenic effect of bioactive glasses and their dissolution products is of great interest for tissue engineering applications in general and in particular for soft tissue regeneration and repair. The third part of this chapter will detail the latest research on these angiogenic properties of bioactive glasses.

Book chapter

Wu Z, Zheng K, Zhang J, Tang T, Guo H, Boccaccini AR, Wei Jet al., 2016, Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair, JOURNAL OF MATERIALS CHEMISTRY B, Vol: 4, Pages: 7974-7988, ISSN: 2050-750X

Journal article

Zheng K, Lu M, Rutkowski B, Dai X, Yang Y, Taccardi N, Stachewicz U, Czyrska-Filemonowicz A, Hueser N, Boccaccini ARet al., 2016, ZnO quantum dots modified bioactive glass nanoparticles with pH-sensitive release of Zn ions, fluorescence, antibacterial and osteogenic properties, JOURNAL OF MATERIALS CHEMISTRY B, Vol: 4, Pages: 7936-7949, ISSN: 2050-750X

Journal article

Sarker B, Li W, Zheng K, Detsch R, Boccaccini ARet al., 2016, Designing Porous Bone Tissue Engineering Scaffolds with Enhanced Mechanical Properties from Composite Hydrogels Composed of Modified Alginate, Gelatin, and Bioactive Glass, ACS BIOMATERIALS SCIENCE & ENGINEERING, Vol: 2, Pages: 2240-2254, ISSN: 2373-9878

Journal article

Tallawi M, Dippold D, Rai R, D'Atri D, Roether JA, Schubert DW, Rosellini E, Engel FB, Boccaccini ARet al., 2016, Novel PGS/PCL electrospun fiber mats with patterned topographical features for cardiac patch applications, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Vol: 69, Pages: 569-576, ISSN: 0928-4931

Journal article

Silva R, Singh R, Sarker B, Papageorgiou DG, Juhasz JA, Roether JA, Cicha I, Kaschta J, Schubert DW, Chrissafis K, Detsch R, Boccaccini ARet al., 2016, Soft-matrices based on silk fibroin and alginate for tissue engineering, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, Vol: 93, Pages: 1420-1431, ISSN: 0141-8130

Journal article

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