Imperial College London

Professor Aldo R. Boccaccini

Faculty of EngineeringDepartment of Materials

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 6731a.boccaccini

 
 
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Location

 

210Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

1189 results found

Boccardi E, Philippart A, Melli V, Altomare L, De Nardo L, Novajra G, Vitale-Brovarone C, Fey T, Boccaccini ARet al., 2016, Bioactivity and Mechanical Stability of 45S5 Bioactive Glass Scaffolds Based on Natural Marine Sponges, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 44, Pages: 1881-1893, ISSN: 0090-6964

Journal article

Francis L, Meng D, Locke IC, Knowles JC, Mordan N, Salih V, Boccaccini AR, Roy Iet al., 2016, Novel poly(3-hydroxybutyrate) composite films containing bioactive glass nanoparticles for wound healing applications, POLYMER INTERNATIONAL, Vol: 65, Pages: 661-674, ISSN: 0959-8103

Journal article

Heise S, Virtanen S, Boccaccini AR, 2016, Tackling Mg alloy corrosion by natural polymer coatings - A review., Journal of Biomedical Materials Research Part A, ISSN: 1552-4965

The field of protective coatings for magnesium and its alloys (e.g. AZ31) using natural polymers is reviewed. Polymers utilized are broadly divided into polysaccharides and proteins. For both polymer classes examples are given focusing on coating processing and characterization. Several analysing methods reported in literature are summarized highlighting the different characterization approaches applied in different studies, which makes difficult a direct comparison of the outcomes. In most cases, the protective behaviour of coatings was determined using electrochemical impedance spectroscopy or by assessing hydrogen evolution in different fluids. Mechanical tests and in vitro cell culture studies have been also carried out on selected coating systems. Overall, the results show the possibility of applying protective coatings based on natural polymers on magnesium and its alloys, however in vivo studies are scarce so that long-term studies in relevant conditions are not yet available. A comparison with the use of synthetic polymers is presented and current challenges and areas for future research are discussed, highlighting the need for further research in the field which should enable broadening the applications of Mg and Mg alloys in medicine. This article is protected by copyright. All rights reserved.

Journal article

Balasubramanian P, Grünewald A, Detsch R, Hupa L, Jokic B, Tallia F, Solanki AK, Jones JR, Boccaccini ARet al., 2016, Ion Release, Hydroxyapatite Conversion, and Cytotoxicity of Boron-containing Bioactive Glass Scaffolds, International Journal of Applied Glass Science, Vol: 7, Pages: 206-215, ISSN: 2041-1286

We report the development and characterization of boron-releasing highly porous three-dimensional bioactive glass (BG) scaffolds fabricated by the foam replica technique. Three types of bioactive glasses with (wt%) 0.2%, 12.5%, 25% B2O3, and related varying SiO2 contents (wt%): 50%, 37.5%, and 25%, were investigated. The well-known 13-93 (silicate) and 13-93B3 (borate) (in wt% - 56.6% B2O3, 5.5% Na2O, 11.1% K2O, 4.6% MgO, 18.5% CaO, 3.7% P2O5) BGs were used as controls to study the influence of the presence of boron on the mechanical properties, surface reactivity, and cytotoxicity of scaffolds. Surface morphology and surface properties of the BG scaffolds were measured. X-ray diffraction (XRD) analyses showed that the scaffolds of all five compositions were amorphous. The scaffolds with 12.5 wt% B2O3 exhibited satisfactory compressive strength in the range of 1-2 MPa. A dissolution study in cell culture medium was carried out, and ion release profiles, and apatite formation of the scaffolds were assessed. The cytotoxicity of the scaffolds was evaluated using a stromal cell line (ST2). Cells were found to attach and spread well on the scaffolds' surfaces. We conclude that borosilicate scaffolds containing 12.5 wt% B2O3 provide the best combination of properties, including relatively high mechanical strength, apatite formation, and cytocompatibility, and thus, they are promising candidates for bone tissue engineering.

Journal article

Detsch R, Ruebner M, Strissel PL, Mohn D, Strasser E, Stark WJ, Strick R, Boccaccini ARet al., 2016, Nanoscale bioactive glass activates osteoclastic differentiation of RAW 264.7 cells, Nanomedicine, Vol: 11, Pages: 1093-1105, ISSN: 1743-5889

Background: There is limited knowledge regarding differentiation of osteoclasts in the presence of nanoscale bioactive glass (nBG). This investigation examined increasing concentrations of 45S5 nBG and their influence on osteoclast differentiation. Materials & methods: Different concentrations of 45S5 nBG were cultured up to 14 days with the murine RAW264.7 cell line and human primary monocytes cultured with M-CSF and RANKL. Results: Culturing cells for 14 days with 500 μg/ml nBG showed a viability of 100%; however DNA synthesis was reduced, supporting differentiation into osteoclast-like cells. Using RAW cells, activation of nine genes, including cell fusion genes, occurred in an nBG concentration dependent manner. Low concentrations of nBG increased expression of genes involved in commitment to cell fusion, whereas high concentrations increased gene expression supporting osteoclast-like differentiation. Conclusion: nBG enhances both RAW264.7 and human osteoclast differentiation. nBG controlled gene expression in a concentration dependent manner could reflect normal regulation during bone growth.

Journal article

Liverani L, Boccaccini AR, 2016, Versatile Production of Poly(Epsilon-Caprolactone) Fibers by Electrospinning Using Benign Solvents, Nanomaterials, Vol: 6, ISSN: 2079-4991

The electrospinning technique is widely used for the fabrication of micro- and nanofibrous structures. Recent studies have focused on the use of less toxic and harmful solvents (benign solvents) for electrospinning, even if those solvents usually require an accurate and longer process of optimization. The aim of the present work is to demonstrate the versatility of the use of benign solvents, like acetic acid and formic acid, for the fabrication of microfibrous and nanofibrous electrospun poly(epsilon-caprolactone) mats. The solvent systems were also shown to be suitable for the fabrication of electrospun structures with macroporosity, as well as for the fabrication of composite electrospun mats, fabricated by the addition of bioactive glass (45S5 composition) particles in the polymeric solution.

Journal article

Cabanas-Polo S, Philippart A, Boccardi E, Hazur J, Boccaccini ARet al., 2016, Facile production of porous bioactive glass scaffolds by the foam replica technique combined with sol-gel/electrophoretic deposition, CERAMICS INTERNATIONAL, Vol: 42, Pages: 5772-5777, ISSN: 0272-8842

Journal article

Miri AK, Muja N, Kamranpour NO, Lepry WC, Boccaccini AR, Clarke SA, Nazhat SNet al., 2016, Ectopic bone formation in rapidly fabricated acellular injectable dense collagen-Bioglass hybrid scaffolds via gel aspiration-ejection, BIOMATERIALS, Vol: 85, Pages: 128-141, ISSN: 0142-9612

Journal article

Sulong MA, Belova IV, Boccaccini AR, Murch GE, Fiedler Tet al., 2016, A model of the mechanical degradation of foam replicated scaffolds, JOURNAL OF MATERIALS SCIENCE, Vol: 51, Pages: 3824-3835, ISSN: 0022-2461

Journal article

Kozon D, Zheng K, Boccardi E, Liu Y, Liverani L, Boccaccini ARet al., 2016, Synthesis of monodispersed Ag-doped bioactive glass nanoparticles via surface modification, Materials, Vol: 9, ISSN: 1996-1944

Monodispersed spherical Ag-doped bioactive glass nanoparticles (Ag-BGNs) were synthesized by a modified Stöber method combined with surface modification. The surface modification was carried out at 25, 60, and 80 °C, respectively, to investigate the influence of processing temperature on particle properties. Energy-dispersive X-ray spectroscopy (EDS) results indicated that higher temperatures facilitate the incorporation of Ag. Hydroxyapatite (HA) formation on Ag-BGNs was detected upon immersion of the particles in simulated body fluid for 7 days, which indicated that Ag-BGNs maintained high bioactivity after surface modification. The conducted antibacterial assay confirmed that Ag-BGNs had an antibacterial effect on E. coli. The above results thereby suggest that surface modification is an effective way to incorporate Ag into BGNs and that the modified BGNs can remain monodispersed as well as exhibit bioactivity and antibacterial capability for biomedical applications.

Journal article

Li W, Jan Zaloga, Ding Y, Liu Y, Janko C, Pischetsrieder M, Alexiou C, Boccaccini ARet al., 2016, Facile preparation of multifunctional superparamagnetic PHBV microspheres containing SPIONs for biomedical applications, Scientific Reports, Vol: 6, ISSN: 2045-2322

The promising potential of magnetic polymer microspheres in various biomedical applications has been frequently reported. However, the surface hydrophilicity of superparamagnetic iron oxide nanoparticles (SPIONs) usually leads to poor or even failed encapsulation of SPIONs in hydrophobic polymer microspheres using the emulsion method. In this study, the stability of SPIONs in poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) solution was significantly increased after surface modification with lauric acid. As a result, magnetic PHBV microspheres with high encapsulation efficiencies (71.0-87.4%) were prepared using emulsion-solvent extraction/evaporation method. Magnetic resonance imaging (MRI) showed significant contrast for the magnetic PHBV microspheres. The toxicity of these magnetic PHBV microspheres towards human T-lymphoma suspension cells and adherent colon carcinoma HT-29 cells was investigated using flow cytometry, and they were shown to be non-toxic in a broad concentration range. A model drug, tetracycline hydrochloride, was used to demonstrate the drug delivery capability and to investigate the drug release behavior of the magnetic PHBV microspheres. The drug was successfully loaded into the microspheres using lauric acid-coated SPIONs as drug carrier, and was released from the microspheres in a diffusion controlled manner. The developed magnetic PHBV microspheres are promising candidates for biomedical applications such as targeted drug delivery and MRI.

Journal article

Shaffer MSP, Diba M, Fam DWH, Boccaccini Aet al., 2016, Electrophoretic deposition of graphene-related materials: A review of the fundamentals, Progress in Materials Science, Vol: 82, Pages: 83-117, ISSN: 1873-2208

The Electrophoretic Deposition (EPD) of graphene-related materials (GRMs) is an attractive strategy for a wide range of applications. This review paper provides an overview of the fundamentals and specific technical aspects of this approach, highlighting its advantages and limitations, in particular considering the issues that arise specifically from the behaviour and dimensionality of GRMs. Since obtaining a stable dispersion of charged particles is a pre-requisite for successful EPD, the strategies for suspending GRMs in different media are discussed, along with the resulting influence on the deposited film. Most importantly, the kinetics involved in the EPD of GRMs and the factors that cause deviation from linearity in Hamaker’s Law are reviewed. Side reactions often influence both the efficiency of deposition and the nature of the deposited material; examples include the reduction of graphene oxide (GO) and related materials, as well as the decomposition of the suspension medium at high potentials. The microstructural characteristics of GRM deposits, including their degree of reduction and orientation, strongly influence their performance in their intended function. These factors will also determine, to a large extent, the commercial potential of this technique for applications involving GRMs, and are therefore discussed here.

Journal article

Kollath VO, Chen Q, Mullens S, Luyten J, Traina K, Boccaccini AR, Cloots Ret al., 2016, Electrophoretic deposition of hydroxyapatite and hydroxyapatite-alginate on rapid prototyped 3D Ti6Al4V scaffolds, JOURNAL OF MATERIALS SCIENCE, Vol: 51, Pages: 2338-2346, ISSN: 0022-2461

Journal article

Gorodzha S, Douglas TE, Samal SK, Detsch R, Cholewa-Kowalska K, Braeckmans K, Boccaccini AR, Skirtach AG, Weinhardt V, Baumbach T, Surmeneva MA, Surmenev RAet al., 2016, High-resolution synchrotron X-ray analysis of bioglass-enriched hydrogels, Journal of Biomedical Materials Research Part A, Vol: 104, Pages: 1194-1201, ISSN: 1552-4965

Enrichment of hydrogels with inorganic particles improves their suitability for bone regeneration by enhancing their mechanical properties, mineralizability, and bioactivity as well as adhesion, proliferation, and differentiation of bone-forming cells, while maintaining injectability. Low aggregation and homogeneous distribution maximize particle surface area, promoting mineralization, cell-particle interactions, and homogenous tissue regeneration. Hence, determination of the size and distribution of particles/particle agglomerates in the hydrogel is desirable. Commonly used techniques have drawbacks. High-resolution techniques (e.g., SEM) require drying. Distribution in the dry state is not representative of the wet state. Techniques in the wet state (histology, µCT) are of lower resolution. Here, self-gelling, injectable composites of Gellan Gum (GG) hydrogel and two different types of sol-gel-derived bioactive glass (bioglass) particles were analyzed in the wet state using Synchrotron X-ray radiation, enabling high-resolution determination of particle size and spatial distribution. The lower detection limit volume was 9 × 10(-5) mm(3) . Bioglass particle suspensions were also studied using zeta potential measurements and Coulter analysis. Aggregation of bioglass particles in the GG hydrogels occurred and aggregate distribution was inhomogeneous. Bioglass promoted attachment of rat mesenchymal stem cells (rMSC) and mineralization. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1194-1201, 2016.

Journal article

Dippold D, Tallawi M, Tansaz S, Roether JA, Boccaccini ARet al., 2016, Novel electrospun poly(glycerol sebacate)-zein fiber mats as candidate materials for cardiac tissue engineering, EUROPEAN POLYMER JOURNAL, Vol: 75, Pages: 504-513, ISSN: 0014-3057

Journal article

Chen Q, Yang Y, Perez de Larraya U, Garmendia N, Virtanen S, Boccaccini ARet al., 2016, Electrophoretic co-deposition of cellulose nanocrystals-45S5 bioactive glass nanocomposite coatings on stainless steel, APPLIED SURFACE SCIENCE, Vol: 362, Pages: 323-328, ISSN: 0169-4332

Journal article

Boccaccini AR, Höland W, 2016, Editorial: Inorganic Biomaterials., Frontiers in Bioengineering and Biotechnology, Vol: 4, ISSN: 2296-4185

Journal article

Naseri S, Lepry WC, Li W, Waters KE, Boccaccini AR, Nazhat SNet al., 2016, 45S5 bioactive glass reactivity by dynamic vapour sorption, JOURNAL OF NON-CRYSTALLINE SOLIDS, Vol: 432, Pages: 47-52, ISSN: 0022-3093

Journal article

Rohanova D, Horkavcova D, Helebrant A, Boccaccini ARet al., 2016, Assessment of in vitro testing approaches for bioactive inorganic materials, JOURNAL OF NON-CRYSTALLINE SOLIDS, Vol: 432, Pages: 53-59, ISSN: 0022-3093

Journal article

Esteban-Tejeda L, Zheng K, Prado C, Cabal B, Torrecillas R, Boccaccini AR, Moya JSet al., 2016, Bone tissue scaffolds based on antimicrobial SiO2-Na2O-Al2O3-CaO-B2O3 glass, JOURNAL OF NON-CRYSTALLINE SOLIDS, Vol: 432, Pages: 73-80, ISSN: 0022-3093

Journal article

Baino F, Novajra G, Miguez-Pacheco V, Boccaccini AR, Vitale-Brovarone Cet al., 2016, Bioactive glasses: Special applications outside the skeletal system, JOURNAL OF NON-CRYSTALLINE SOLIDS, Vol: 432, Pages: 15-30, ISSN: 0022-3093

Journal article

Boccaccini AR, Rahaman MN, 2016, Glasses in Healthcare Preface, JOURNAL OF NON-CRYSTALLINE SOLIDS, Vol: 432, Pages: 1-1, ISSN: 0022-3093

Journal article

Miguez-Pacheco V, Buettner T, Macon ALB, Jones JR, Fey T, de Ligny D, Greil P, Chevalier J, Malchere A, Boccaccini ARet al., 2016, Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair, JOURNAL OF NON-CRYSTALLINE SOLIDS, Vol: 432, Pages: 65-72, ISSN: 0022-3093

Journal article

Schacht K, Jüngst T, Zehnder T, Boccaccini AR, Groll J, Scheibel Tet al., 2016, Zellgewebe aus dem Drucker, Nachrichten aus der Chemie, Vol: 64, Pages: 13-16, ISSN: 1439-9598

Die Biofabrikation, also die Verarbeitung von Biotinte, baut mit zellfreundlichen 3-D-Druckverfahren gewebeartige Strukturen auf. Die Zusammensetzung von Biotinten steht daher im Fokus der Materialentwickler, die Gewebe züchten.

Journal article

Ding Y, Souza MT, Li W, Schubert DW, Boccaccini AR, Roether JAet al., 2016, Bioactive glass-biopolymer composites for applications in tissue engineering, Handbook of Bioceramics and Biocomposites, Pages: 325-356, ISBN: 9783319124599

© Springer International Publishing Switzerland 2016. Tissue engineering (TE) is a biomedical field in continuous expansion. However, there are still many challenges to be tackled. The further development of TE approaches requires interdisciplinary interaction and collaboration among various research areas with a notable contribution expected from biomaterials science. In the last couple of decades, significant advances in the development of biomaterial-based scaffolds for hard and soft tissue regeneration have been accomplished, including the manufacture of biocomposites that combine natural or synthetic polymers with bioactive glasses or glass-ceramics. These novel biomaterials present the possibility of tailoring a variety of parameters and properties such as degradation kinetics, mechanical properties, and chemical composition according to the aimed application. This chapter presents a concise update of the field of biopolymer–bioactive glass composite scaffold development for TE covering several popular processing techniques for biocomposite fabrication, namely, microsphere processing, solvent casting-particulate leaching method, electrospinning, freeze-drying, and rapid prototyping techniques, which lead to scaffolds exhibiting a variety of 3D morphologies and different pore structures.

Book chapter

Lizarraga-Valderrama LR, Panchal B, Thomas C, Boccaccini AR, Roy Iet al., 2016, Biomedical Applications of Polyhydroxyalkanoates, Biomaterials from Nature for Advanced Devices and Therapies, Pages: 337-383, ISBN: 9781118478059

© 2016 by John Wiley & Sons, Inc. All rights reserved. Polyhydroxyalkanoates (PHAs) are a family of linear polyesters consisting of 3,4, 5 and 6-hydroxyacids, synthesized by a variety of bacterial species. PHAs are divided into two groups based on the number of carbon atoms in their monomer units; short-chain-length (scl) PHAs and medium-chain-length (mcl) PHAs. Biodegradability is an essential material property required for tissue engineering and drug delivery applications. Various methods of manufacture can be used to alter the biodegradability of PHA devices such as by blending with others polymers, increasing the porosity and increasing the exposed surface area. PHAs have also been demonstrated to be suitable for use as scaffolds in tissue engineering since they are easily degradable and favor proliferation and attachment of cells. In the field of skin tissue engineering research, various skin components, cytokines, growth factors, and transcription factors have been used experimentally. Melanocytes have been seeded on various polymer scaffolds, as well as sweat and sebaceous glands.

Book chapter

Goudouri OM, Vogel C, Grünewald A, Detsch R, Kontonasaki E, Boccaccini ARet al., 2016, Sol-gel processing of novel bioactive Mg-containing silicate scaffolds for alveolar bone regeneration., Journal of Biomaterials Applications, Vol: 30, Pages: 740-749, ISSN: 1530-8022

Periodontal tissue regeneration is an important application area of biomaterials, given the large proportion of the population affected by periodontal diseases like periodontitis. The aim of this study was the synthesis of a novel porous bioceramic scaffold in the SiO2-CaO-MgO system with specific properties targeted for alveolar bone tissue regeneration using a modification of the traditional foam replica technique. Since bioceramic scaffolds are considered brittle, scaffolds were also coated with gelatin in order to increase their mechanical stability. Gelatin was chosen for its biocompatibility, biodegradability, low-cost, and low immunogenicity. However, gelatin degrades very fast in water solutions. For this reason, two different cross-linking agents were evaluated. Genipin, a non-toxic gardenia extract and the chemical compound 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) in combination with N-hydroxysuccinimide (NHS), which is also considered non-toxic. The results of the investigation indicated that all scaffolds presented an open, interconnected porosity and pores' sizes in the range of 300-600 μm, fast apatite-forming ability, biocompatibility, and suitable mechanical stability.

Journal article

Boccaccini AR, Ferrari B, Dickerson JH, Galassi Cet al., 2016, Special Issue: Electrophoretic deposition of ceramics, Journal of the European Ceramic Society, Vol: 36, Pages: 263-263, ISSN: 0955-2219

Journal article

Utech S, Boccaccini AR, 2016, A review of hydrogel-based composites for biomedical applications: enhancement of hydrogel properties by addition of rigid inorganic fillers, Journal of Materials Science, Vol: 51, Pages: 271-310, ISSN: 0022-2461

There is a growing demand for three-dimensional scaffolds for expanding applications in regenerative medicine, tissue engineering, and cell culture techniques. The material requirements for such three-dimensional structures are as diverse as the applications themselves. A wide range of materials have been investigated in the recent decades in order to tackle these requirements and to stimulate the anticipated biological response. Among the most promising class of materials are inorganic/organic hydrogel composites for regenerative medicine. The generation of synergetic effects by hydrogel composite systems enables the design of materials with superior properties including biological performance, stiffness, and degradation behavior in vitro and in vivo. Here, we review the most important organic and inorganic materials used to fabricate hydrogel composites. We highlight the advantages of combining different materials with respect to their use for biofabrication and cell encapsulation as well as their application as injectable materials for tissue enhancement and regeneration. Graphical abstract: [Figure not available: see fulltext.]

Journal article

Ding Y, Yao Q, Li W, Schubert DW, Boccaccini AR, Roether JAet al., 2015, The evaluation of physical properties and in vitro cell behavior of PHB/PCL/sol-gel derived silica hybrid scaffolds and PHB/PCL/fumed silica composite scaffolds, COLLOIDS AND SURFACES B-BIOINTERFACES, Vol: 136, Pages: 93-98, ISSN: 0927-7765

Journal article

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