Imperial College London

Professor Aldo R. Boccaccini

Faculty of EngineeringDepartment of Materials

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 6731a.boccaccini

 
 
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Location

 

210Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

1189 results found

Ding Y, Yao Q, Li W, Schubert DW, Boccaccini AR, Roether JAet al., 2015, The evaluation of physical properties and in vitro cell behavior of PHB/PCL/sol-gel derived silica hybrid scaffolds and PHB/PCL/fumed silica composite scaffolds, COLLOIDS AND SURFACES B-BIOINTERFACES, Vol: 136, Pages: 93-98, ISSN: 0927-7765

Journal article

Cabanas-Polo S, Distaso M, Peukert W, Boccaccini ARet al., 2015, Electrophoretic Deposition of alpha-Fe2O3/Chitosan Nanocomposite Coatings for Functional and Biomedical Applications, JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, Vol: 15, Pages: 10149-10155, ISSN: 1533-4880

Journal article

Hoppe A, Brandl A, Bleiziffer O, Arkudas A, Horch RE, Jokic B, Janackovic D, Boccaccini ARet al., 2015, In vitro cell response to Co-containing 1393 bioactive glass, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Vol: 57, Pages: 157-163, ISSN: 0928-4931

Journal article

Yang Y, Michalczyk C, Singer F, Virtanen S, Boccaccini ARet al., 2015, In vitro study of polycaprolactone/bioactive glass composite coatings on corrosion and bioactivity of pure Mg, APPLIED SURFACE SCIENCE, Vol: 355, Pages: 832-841, ISSN: 0169-4332

Journal article

Unterweger H, Subatzus D, Tietze R, Janko C, Poettler M, Stiegelschmitt A, Schuster M, Maake C, Boccaccini AR, Alexiou Cet al., 2015, Hypericin-bearing magnetic iron oxide nanoparticles for selective drug delivery in photodynamic therapy., International Journal of Nanomedicine, Vol: 10, Pages: 6985-6996, ISSN: 1178-2013

Combining the concept of magnetic drug targeting and photodynamic therapy is a promising approach for the treatment of cancer. A high selectivity as well as significant fewer side effects can be achieved by this method, since the therapeutic treatment only takes place in the area where accumulation of the particles by an external electromagnet and radiation by a laser system overlap. In this article, a novel hypericin-bearing drug delivery system has been developed by synthesis of superparamagnetic iron oxide nanoparticles (SPIONs) with a hypericin-linked functionalized dextran coating. For that, sterically stabilized dextran-coated SPIONs were produced by coprecipitation and crosslinking with epichlorohydrin to enhance stability. Carboxymethylation of the dextran shell provided a functionalized platform for linking hypericin via glutaraldehyde. Particle sizes obtained by dynamic light scattering were in a range of 55-85 nm, whereas investigation of single magnetite or maghemite particle diameter was performed by transmission electron microscopy and X-ray diffraction and resulted in approximately 4.5-5.0 nm. Surface chemistry of those particles was evaluated by Fourier transform infrared spectroscopy and ζ potential measurements, indicating successful functionalization and dispersal stabilization due to a mixture of steric and electrostatic repulsion. Flow cytometry revealed no toxicity of pure nanoparticles as well as hypericin without exposure to light on Jurkat T-cells, whereas the combination of hypericin, alone or loaded on particles, with light-induced cell death in a concentration and exposure time-dependent manner due to the generation of reactive oxygen species. In conclusion, the combination of SPIONs' targeting abilities with hypericin's phototoxic properties represents a promising approach for merging magnetic drug targeting with photodynamic therapy for the treatment of cancer.

Journal article

Chen Q, Perez Garcia R, Munoz J, Perez de Larraya U, Garmendia N, Yao Q, Boccaccini ARet al., 2015, Cellulose Nanocrystals-Bioactive Glass Hybrid Coating as Bone Substitutes by Electrophoretic Co-deposition: In Situ Control of Mineralization of Bioactive Glass and Enhancement of Osteoblastic Performance, ACS APPLIED MATERIALS & INTERFACES, Vol: 7, Pages: 24715-24725, ISSN: 1944-8244

Journal article

Detsch R, Sarker B, Zehnder T, Frank G, Boccaccini ARet al., 2015, Advanced alginate-based hydrogels, Materials Today, Vol: 18, Pages: 590-591, ISSN: 1369-7021

Journal article

Boccardi E, Philippart A, Juhasz-Bortuzzo JA, Beltrán AM, Novajra G, Vitale-Brovarone C, Spiecker E, Boccaccini ARet al., 2015, Uniform surface modification of 3D Bioglass®-based scaffolds with mesoporous silica particles (MCM-41) for enhancing drug delivery capability, Frontiers in Bioengineering and Biotechnology, Vol: 3, ISSN: 2296-4185

The design and characterization of a new family of multifunctional scaffolds based on bioactive glass (BG) of 45S5 composition for bone tissue engineering and drug delivery applications are presented. These BG-based scaffolds are developed via a replication method of polyurethane packaging foam. In order to increase the therapeutic functionality, the scaffolds were coated with mesoporous silica particles (MCM-41), which act as an in situ drug delivery system. These sub-micron spheres are characterized by large surface area and pore volume with a narrow pore diameter distribution. The solution used for the synthesis of the silica mesoporous particles was designed to obtain a high-ordered mesoporous structure and spherical shape – both are key factors for achieving the desired controlled drug release. The MCM-41 particles were synthesized directly inside the BG-based scaffolds, and the drug-release capability of this combined system was evaluated. Moreover, the effect of MCM-41 particle coating on the bioactivity of the BG-based scaffolds was assessed. The results indicate that it is possible to obtain a multifunctional scaffold system characterized by high and interconnected porosity, high bioactivity, and sustained drug delivery capability.

Journal article

Zheng K, Bortuzzo JA, Liu Y, Li W, Pischetsrieder M, Roether J, Lu M, Boccaccini ARet al., 2015, Bio-templated bioactive glass particles with hierarchical macro-nano porous structure and drug delivery capability, COLLOIDS AND SURFACES B-BIOINTERFACES, Vol: 135, Pages: 825-832, ISSN: 0927-7765

Journal article

Yao Q, Li W, Yu S, Ma L, Jin D, Boccaccini AR, Liu Yet al., 2015, Multifunctional chitosan/polyvinyl pyrrolidone/45S5 Bioglasse (R) scaffolds for MC3T3-E1 cell stimulation and drug release, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Vol: 56, Pages: 473-480, ISSN: 0928-4931

Journal article

Balasubramanian P, Boccaccini AR, 2015, Bilayered bioactive glass scaffolds incorporating fibrous morphology by flock technology, MATERIALS LETTERS, Vol: 158, Pages: 313-316, ISSN: 0167-577X

Journal article

Boccaccini AR, Ferraris M, Reece MJ, Salvo Met al., 2015, GlaCERCo: Glass and Ceramic Composites for High Technology Applications - Marie Curie Initial Training Network, Advances in Applied Ceramics, Vol: 114, Pages: S1-S2, ISSN: 1743-6753

Journal article

Singh R, Sarker B, Silva R, Detsch R, Dietel B, Alexiou C, Boccaccini AR, Cicha Iet al., 2015, Evaluation of hydrogel matrices for vessel bioplotting: Vascular cell growth and viability, Journal of Biomedical Materials Research Part A, Vol: 104, Pages: 577-585, ISSN: 1552-4965

Developing matrices biocompatible with vascular cells is one of the most challenging tasks in tissue engineering. Here, we compared the growth of vascular cells on different hydrogels as potential materials for bioplotting of vascular tissue. Formulations containing alginate solution (Alg, 2%, w/v) blended with protein solutions (silk fibroin, gelatin, keratin, or elastin) at 1% w/v were prepared. Human umbilical vein endothelial cells (ECs), smooth muscle cells (SMCs), and fibroblasts were cultivated on hydrogels for 7 days. Cell number and morphology was visualised using fluorescent staining at day 3 and 7. Cell metabolic activity was analysed using WST assay. Compared to pure Alg, Alg/keratin, Alg/gelatin and Alg/silk fibroin provided superb surfaces for ECs, supporting their attachment, growth, spreading and metabolic activity. SMCs showed best colonization and growth on Alg/silk fibroin and Alg/keratin hydrogels, whereas on elastin-containing hydrogels, cell clustering was observed. Fibroblasts growth was enhanced on Alg/elastin, and strongly improved on silk fibroin- and keratin-containing hydrogels. In contrast to the previous studies with alginate dialdehyde-gelatin crosslinked gels, Alg/gelatin blend hydrogels provided a less favourable scaffold for fibroblasts. Taken together, the most promising results were obtained with silk fibroin- and keratin-containing hydrogels, which supported the growth of all types of vascular cells. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2015.

Journal article

Pröschel M, Detsch R, Boccaccini AR, Sonnewald Uet al., 2015, Engineering of Metabolic Pathways by Artificial Enzyme Channels., Frontiers in Bioengineering and Biotechnology, Vol: 3, ISSN: 2296-4185

Application of industrial enzymes for production of valuable chemical compounds has greatly benefited from recent developments in Systems and Synthetic Biology. Both, in vivo and in vitro systems have been established, allowing conversion of simple into complex compounds. Metabolic engineering in living cells needs to be balanced which is achieved by controlling gene expression levels, translation, scaffolding, compartmentation, and flux control. In vitro applications are often hampered by limited protein stability/half-life and insufficient rates of substrate conversion. To improve stability and catalytic activity, proteins are post-translationally modified and arranged in artificial metabolic channels. Within the review article, we will first discuss the supramolecular organization of enzymes in living systems and second summarize current and future approaches to design artificial metabolic channels by additive manufacturing for the efficient production of desired products.

Journal article

Miola M, Verné E, Ciraldo FE, Cordero-Arias L, Boccaccini ARet al., 2015, Electrophoretic Deposition of Chitosan/45S5 Bioactive Glass Composite Coatings Doped with Zn and Sr., Frontiers in Bioengineering and Biotechnology, Vol: 3, ISSN: 2296-4185

In this research work, the original 45S5 bioactive glass was modified by introducing zinc and/or strontium oxide (6 mol%) in place of calcium oxide. Sr was added for its ability to stimulate bone formation and Zn for its role in bone metabolism, antibacterial properties, and anti-inflammatory effect. The glasses were produced by means of melting and quenching process. SEM and XRD analyses evidenced that Zr and Sr introduction did not modify the glass structure and morphology while compositional analysis (EDS) demonstrated the effective incorporation of these elements in the glass network. Bioactivity test in simulated body fluid (SBF) up to 1 month evidenced a reduced bioactivity kinetics for Zn-doped glasses. Doped glasses were combined with chitosan to produce organic/inorganic composite coatings on stainless steel AISI 316L by electrophoretic deposition (EPD). Two EPD processes were considered for coating development, namely direct current EPD (DC-EPD) and alternating current EPD (AC-EPD). The stability of the suspension was analyzed and the deposition parameters were optimized. Tape and bending tests demonstrated a good coating-substrate adhesion for coatings containing 45S5-Sr and 45S5-ZnSr glasses, whereas the adhesion to the substrate decreased by using 45S5-Zn glass. FTIR analyses demonstrated the composite nature of coatings and SEM observations indicated that glass particles were well integrated in the polymeric matrix, the coatings were fairly homogeneous and free of cracks; moreover, the AC-EPD technique provided better results than DC-EPD in terms of coating quality. SEM, XRD analyses, and Raman spectroscopy, performed after bioactivity test in SBF solution, confirmed the bioactive behavior of 45S5-Sr-containing coating while coatings containing Zn exhibited no hydroxyapatite formation.

Journal article

Tansaz S, Boccaccini AR, 2015, Biomedical applications of soy protein: A brief overview., Journal of Biomedical Materials Research Part A, Vol: 104, Pages: 553-569, ISSN: 1552-4965

Soy protein (SP) based materials are gaining increasing interest for biomedical applications because of their tailorable biodegradability, abundance, being relatively inexpensive, exhibiting low immunogenicity, and for being structurally similar to components of the extracellular matrix (ECM) of tissues. Analysis of the available literature indicates that soy protein can be fabricated into different shapes, being relatively easy to be processed by solvent or melt based techniques. Furthermore soy protein can be blended with other synthetic and natural polymers and with inorganic materials to improve the mechanical properties and the bioactive behavior for several demands. This review discusses succinctly the biomedical applications of SP based materials focusing on processing methods, properties and applications highlighting future avenues for research. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 553-569, 2016.

Journal article

Cordero-Arias L, Cabanas-Polo S, Goudouri OM, Misra SK, Gilabert J, Valsami-Jones E, Sanchez E, Virtanen S, Boccaccini ARet al., 2015, Electrophoretic deposition of ZnO/alginate and ZnO-bioactive glass/alginate composite coatings for antimicrobial applications, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Vol: 55, Pages: 137-144, ISSN: 0928-4931

Journal article

Balasubramanian P, Roether JA, Schubert DW, Beier JP, Boccaccini ARet al., 2015, Bi-layered porous constructs of PCL-coated 45S5 bioactive glass and electrospun collagen-PCL fibers, JOURNAL OF POROUS MATERIALS, Vol: 22, Pages: 1215-1226, ISSN: 1380-2224

Journal article

Locs J, Li W, Sokolova M, Roether JA, Loca D, Boccaccini ARet al., 2015, Zoledronic acid impregnated and poly (L-lactic acid) coated 45S5 Bioglass (R)-based scaffolds, MATERIALS LETTERS, Vol: 156, Pages: 180-182, ISSN: 0167-577X

Journal article

Detsch R, Boccaccini AR, 2015, The role of osteoclasts in bone tissue engineering, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol: 9, Pages: 1133-1149, ISSN: 1932-6254

Journal article

Li W, Ding Y, Yu S, Yao Q, Boccaccini ARet al., 2015, Multifunctional Chitosan-45S5 Bioactive Glass-Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Microsphere Composite Membranes for Guided Tissue/Bone Regeneration, ACS APPLIED MATERIALS & INTERFACES, Vol: 7, Pages: 20845-20854, ISSN: 1944-8244

Journal article

Rai R, Tallawi M, Frati C, Falco A, Gervasi A, Quaini F, Roether JA, Hochburger T, Schubert DW, Seik L, Barbani N, Lazzeri L, Rosellini E, Boccaccini ARet al., 2015, Bioactive Electrospun Fibers of Poly(glycerol sebacate) and Poly(e-caprolactone) for Cardiac Patch Application, ADVANCED HEALTHCARE MATERIALS, Vol: 4, Pages: 2012-2025, ISSN: 2192-2640

Journal article

Cattalini JP, Hoppe A, Pishbin F, Roether J, Boccaccini AR, Lucangioli S, Mourino Vet al., 2015, Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 12, ISSN: 1742-5689

Journal article

Nerantzaki M, Filippousi M, Van Tendeloo G, Terzopoulou Z, Bikiaris D, Goudouri OM, Detsch R, Grueenewald A, Boccaccini ARet al., 2015, Novel poly(butylene succinate) nanocomposites containing strontium hydroxyapatite nanorods with enhanced osteoconductivity for tissue engineering applications, EXPRESS POLYMER LETTERS, Vol: 9, Pages: 773-789, ISSN: 1788-618X

Journal article

Fereshteh Z, Nooeaid P, Fathi M, Bagri A, Boccaccini ARet al., 2015, The effect of coating type on mechanical properties and controlled drug release of PCL/zein coated 45S5 bioactive glass scaffolds for bone tissue engineering, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Vol: 54, Pages: 50-60, ISSN: 0928-4931

Journal article

Novajra G, Perdika P, Pisano R, Miola M, Bari A, Jones JR, Detsch R, Boccaccini AR, Vitale-Brovarone Cet al., 2015, Structure optimisation and biological evaluation of bone scaffolds prepared by co-sintering of silicate and phosphate glasses, Advances in Applied Ceramics, Vol: 114, Pages: S48-S55, ISSN: 1743-6761

A degradable phosphate glass (ICEL) and a bioactive silicate glass (CEL2) were mixed indifferent ratios (wt-%: 100%ICEL, 70%ICEL–30%CEL2, 30%ICEL–70%CEL2, 100%CEL2; codes100-0, 70-30, 30-70, 0-100) and then co-sintered to obtain three-dimensional porous scaffolds bygel casting foaming. Thermal analyses were carried out on the glass mixtures and were used as astarting point for the optimisation of the scaffold sintering treatment. The microcomputedtomography and field emission scanning electron microscope analyses allowed the selection ofthe optimal sintering temperature to obtain an adequate structure in terms of total and openporosity. The scaffolds showed an increasing solubility with increasing ICEL glass content, and for30-70 and 0-100, the precipitation of hydroxyapatite in simulated body fluid was observed. In vitrotests indicated that all the scaffolds showed no cytotoxic effect. The co-sintering of silicate andphosphate glasses showed to be a promising strategy to tailor the scaffold osteoconductivity,degradation and bioactivity.

Journal article

Gradzik B, Stenzel A, Boccaccini AR, El Fray Met al., 2015, Influence of functionalized halloysite clays (HNT) on selected properties of multiblock (e)PBS-EG copolymer obtained by enzymatic catalysis, DESIGNED MONOMERS AND POLYMERS, Vol: 18, Pages: 501-511, ISSN: 1385-772X

Journal article

Cabanas-Polo S, Boccaccini AR, 2015, Electrophoretic deposition of nanoscale TiO2: technology and applications, Journal of the European Ceramic Society, Vol: 36, Pages: 265-283, ISSN: 1873-619X

The importance of titania (TiO2) as the main component of photocatalytic and photovoltaic devices or its employment in sensors, biomedical coatings and as anticorrosion or antioxidation agent, is highlighted by the increasing number of systems in which titania is being widely used. Many of the attractive applications of TiO2 require the manufacture of thin (and thick) films and layered structures In this regard, electrophoretic deposition (EPD) has gained increasing attention over the last years to process TiO2 nanoparticles (n-TiO2) for production of a variety of TiO2 layers, films and coatings. This review compiles the different aspects involved in the fabrication of TiO2 coatings by EPD of n-TiO2, first focusing on the general aspects of the deposition process and the parameters involved, and considering further the specific requirements for given applications. The recent advances achieved are discussed and avenues for future research and innovations on the EPD of n-TiO2 are highlighted.

Journal article

Zheng K, Wu Z, Wei J, Russel C, Liang W, Boccaccini ARet al., 2015, Preparation and characterization of fibrous chitosan-glued phosphate glass fiber scaffolds for bone regeneration, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, Vol: 26, ISSN: 0957-4530

Journal article

Greco KV, Francis L, Somasundaram M, Greco G, English NR, Roether JA, Boccaccini AR, Sibbons P, Ansari Tet al., 2015, Characterisation of porcine dermis scaffolds decellularised using a novel non-enzymatic method for biomedical applications, JOURNAL OF BIOMATERIALS APPLICATIONS, Vol: 30, Pages: 239-253, ISSN: 0885-3282

Journal article

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