Imperial College London

Professor Aldo R. Boccaccini

Faculty of EngineeringDepartment of Materials

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 6731a.boccaccini

 
 
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Location

 

210Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

1189 results found

Miguez-Pacheco V, Greenspan D, Hench LL, Boccaccini ARet al., 2015, Bioactive glasses in soft tissue repair, AMERICAN CERAMIC SOCIETY BULLETIN, Vol: 94, Pages: 27-31, ISSN: 0002-7812

Journal article

Chinnam RK, Bernardo E, Will J, Boccaccini ARet al., 2015, Processing of porous glass ceramics from highly crystallisable industrial wastes, Advances in Applied Ceramics, Vol: 114, Pages: S11-S16, ISSN: 1743-6753

This study was carried out to gain understanding about the sintering behaviour of highly crystallisable industrial waste derived silicate mixtures under direct heating and rapid cooling conditions. The materials used in this study were plasma vitrified air pollution control waste and rejected pharmaceutical borosilicate glass. Powder compacts sintered under direct heating conditions were highly porous; compacts with particle size <38 μm reached a maximum density of 2.74 g cm-3 at 850°C, whereas compacts with particles of size <100 and <250 mm reached maximum densities of 2.69 and 2.72 g cm-3 at 875 and 900°C respectively. Further increase in sintering temperature resulted in a rapid decrease in density of the glass ceramics. Image analysis results were used to link the sudden drop in density to the increase in volume of microsized pores formed in the samples during sintering. In particular, compacts made from ,38 mm particles sintered at 9508C resulted in 65 vol.-% porosity with a pore size of <20 μm. Such materials can be used for sound and thermal insulation purposes.

Journal article

Fereshteh Z, Nooeaid P, Fathi M, Bagri A, Boccaccini ARet al., 2015, Mechanical properties and drug release behavior of PCL/zein coated 45S5 bioactive glass scaffolds for bone tissue engineering application., Data in Brief, Vol: 4, Pages: 524-528, ISSN: 2352-3409

This article presents data related to the research article entitled "The effect of coating type on mechanical properties and controlled drug release of PCL/zein coated 45S5 bioactive glass scaffolds for bone tissue engineering" [1]. We provide data on mechanical properties, in vitro bioactivity and drug release of bioactive glass (BG) scaffolds coated by poly (ε-caprolactone) (PCL) and zein used as a controlled release device for tetracycline hydrochloride (TCH). By coating the BG scaffolds with PCL or PCL/zein blend the mechanical properties of the scaffolds were substantially improved, i.e., the compressive strength increased from 0.004±0.001 MPa (uncoated BG scaffolds) to 0.15±0.02 MPa (PCL/zein coated BG scaffolds). A dense bone-like apatite layer formed on the surface of PCL/zein coated scaffolds immersed for 14 days in simulated body fluid (SBF). The data describe control of drug release and in vitro degradation behavior of coating by engineering the concentration of zein. Thus, the developed scaffolds exhibit attractive properties for application in bone tissue engineering research.

Journal article

Ponsot I, Detsch R, Boccaccini AR, Bernardo Eet al., 2015, Waste derived glass ceramic composites prepared by low temperature sintering/sinter-crystallisation, Advances in Applied Ceramics, Vol: 114, Pages: S17-S25, ISSN: 1743-6753

Glass-ceramics based on iron rich wastes were produced by direct sintering and by following an innovative approach, combining direct sintering and sinter-crystallisation processes. According to the second method, a layered tile was manufactured by single firing at 9008C using a selected combination of wastes for both the porous body and the dense coating layer. The coating layer ('glaze') results from the sinter-crystallisation of a waste derived glass mixed with zircon and recycled borosilicate glass. The glaze sealed the porosity of the body and enhanced both mechanical properties and chemical stability. The results show a near to zero water absorption rate, despite a low geometric density (∼2 g cm-3), accompanied by a Young's modulus of ∼40 GPa and a bending strength of ∼30 MPa. The chemical stability of the glass-ceramics thus developed was assessed by the application of a toxicity control leaching procedure. Furthermore, cell culture tests were carried out to evaluate the potential cytotoxicity of the materials.

Journal article

Tallawi M, Rosellini E, Barbani N, Cascone MG, Rai R, Saint-Pierre G, Boccaccini ARet al., 2015, Strategies for the chemical and biological functionalization of scaffolds for cardiac tissue engineering: a review, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 12, ISSN: 1742-5689

Journal article

Bertolla L, Chlup Z, Stratil L, Boccaccini AR, Dlouhý Iet al., 2015, Effect of hybrid polymer coating of Bioglass® foams on mechanical response during tensile loading, Advances in Applied Ceramics, Vol: 114, Pages: S63-S69, ISSN: 1743-6753

A simplified two-dimensional finite elements model was created for a polyvinyl alcohol (PVA) coated BioglassH strut undergoing tensile stresses (loading mode I). The strengthening contributions due to the infiltration of coating into surface cracks and coating's stiffness were evaluated in terms of stress intensity factor KI and tensile stresses σyy in the proximity of the crack tip. The infiltration of the coating until the crack tip resulted as themost effective criterion for the struts strengthening. BioglassH based scaffolds were dip coated into PVA and PVA/microfibrillated cellulose (MFC) aqueous solutions and tested in tensile load. Coated samples exhibited remarkably higher tensile strength than non-coated ones, which further raised with the increased amount of MFC. Contact angle θ and linear viscosity n measurements of PVA/MFCsolutions showedthatMFCcauseda reduction inh andadrastic increase in θ, indicating that a balance between these two effects must be achieved.

Journal article

Boccardi E, Philippart A, Juhasz-Bortuzzo JA, Novajra G, Vitale-Brovarone C, Boccaccini ARet al., 2015, Characterisation of Bioglass based foams developed via replication of natural marine sponges, Advances in Applied Ceramics, Vol: 114, Pages: S56-S62, ISSN: 1743-6753

A comparative characterisation of Bioglass based scaffolds for bone tissue engineering applications developed via a replication technique of natural marine sponges as sacrificial template is presented, focusing on their architecture and mechanical properties. The use of these sponges presents several advantages, including the possibility of attaining higher mechanical properties than those scaffolds made by foam replica method (up to 4 MPa) due to a decrease in porosity (68-76%) without affecting the pore interconnectivity (higher than 99%). The obtained pore structure possesses not only pores with a diameter in the range 150-500 mm, necessary to induce bone ingrowth, but also pores in the range of 0-200 mm, which are requested for complete integration of the scaffold and for neovascularisation. In this way, it is possible to combine the main properties that a three-dimensional scaffold should have for bone regeneration: interconnected and high porosity, adequate mechanical properties and bioactivity.

Journal article

Chatzistavrou X, Velamakanni S, DiRenzo K, Lefkelidou A, Fenno JC, Kasuga T, Boccaccini AR, Papagerakis Pet al., 2015, Designing dental composites with bioactive and bactericidal properties, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Vol: 52, Pages: 267-272, ISSN: 0928-4931

Journal article

El-Gendy R, Kirkham J, Newby PJ, Mohanram Y, Boccaccini AR, Yang XBet al., 2015, Investigating the Vascularization of Tissue-Engineered Bone Constructs Using Dental Pulp Cells and 45S5 Bioglass (R) Scaffolds, TISSUE ENGINEERING PART A, Vol: 21, Pages: 2034-2043, ISSN: 1937-3341

Journal article

Sarker B, Rompf J, Silva R, Lang N, Detsch R, Kaschta J, Fabry B, Boccaccini ARet al., 2015, Alginate-based hydrogels with improved adhesive properties for cell encapsulation, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, Vol: 78, Pages: 72-78, ISSN: 0141-8130

Journal article

Simpson RL, Nazhat SN, Blaker JJ, Bismarck A, Hill R, Boccaccini AR, Hansen UN, Amis AAet al., 2015, A comparative study of the effects of different bioactive fillers in PLGA matrix composites and their suitability as bone substitute materials: A thermo-mechanical and in vitro investigation., Journal of the Mechanical Behavior of Biomedical Materials, Vol: 50, Pages: 277-289, ISSN: 1751-6161

Bone substitute composite materials with poly(L-lactide-co-glycolide) (PLGA) matrices and four different bioactive fillers: CaCO3, hydroxyapatite (HA), 45S5 Bioglass(®) (45S5 BG), and ICIE4 bioactive glass (a lower sodium glass than 45S5 BG) were produced via melt blending, extrusion and moulding. The viscoelastic, mechanical and thermal properties, and the molecular weight of the matrix were measured. Thermogravimetric analysis evaluated the effect of filler composition on the thermal degradation of the matrix. Bioactive glasses caused premature degradation of the matrix during processing, whereas CaCO3 or HA did not. All composites, except those with 45S5 BG, had similar mechanical strength and were stiffer than PLGA alone in compression, whilst all had a lower tensile strength. Dynamic mechanical analysis demonstrated an increased storage modulus (E') in the composites (other than the 45S5 BG filled PLGA). The effect of water uptake and early degradation was investigated by short-term in vitro aging in simulated body fluid, which indicated enhanced water uptake over the neat polymer; bioactive glass had the greatest water uptake, causing matrix plasticization. These results enable a direct comparison between bioactive filler type in poly(α-hydroxyester) composites, and have implications when selecting a composite material for eventual application in bone substitution.

Journal article

Scheithauer EC, Li W, Ding Y, Harhaus L, Roether JA, Boccaccini ARet al., 2015, Preparation and characterization of electrosprayed daidzein-loaded PHBV microspheres, Materials Letters, Vol: 158, Pages: 66-69, ISSN: 0167-577X

© 2015 Elsevier B.V. All rights reserved. Given that hormone therapy of osteoporosis with estrogen and progesterone may have potential negative side effects, there is a strong need of developing alternative solutions. Possible therapy alternatives involve the use of phytoestrogens such as daidzein. In this study, daidzein-loaded poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microspheres were prepared using electrospraying. The obtained microspheres had uniform surface morphology, and narrow particle size distribution with mean particle size of 4.8 μm. Daidzein was determined to be in amorphous state in the PHBV microspheres by differential scanning calorimetry analysis. Encapsulated daidzein was released with a low initial burst release (7.6% at 1 h) followed by a sustained release over a period of ~3 days. The developed PHBV microspheres with daidzein delivery function have potential applications in the treatment of osteoporosis and for bone tissue engineering.

Journal article

Gmeiner R, Deisinger U, Schoenherr J, Lechner B, Detsch R, Boccaccini AR, Stampfl Jet al., 2015, Additive Manufacturing of Bioactive Glasses and Silicate Bioceramics, JOURNAL OF CERAMIC SCIENCE AND TECHNOLOGY, Vol: 6, Pages: 75-86, ISSN: 2190-9385

Journal article

Tallawi M, Zebrowski DC, Rai R, Roether JA, Schubert DW, El Fray M, Engel FB, Aifantis KE, Boccaccini ARet al., 2015, Poly(Glycerol Sebacate)/Poly(Butylene Succinate-Butylene Dilinoleate) Fibrous Scaffolds for Cardiac Tissue Engineering, TISSUE ENGINEERING PART C-METHODS, Vol: 21, Pages: 585-596, ISSN: 1937-3384

Journal article

Staehli C, James-Bhasin M, Hoppe A, Boccaccini AR, Nazhat SNet al., 2015, Effect of ion release from Cu-doped 45S5 Bioglass (R) on 3D endothelial cell morphogenesis, ACTA BIOMATERIALIA, Vol: 19, Pages: 15-22, ISSN: 1742-7061

Journal article

Zehnder T, Sarker B, Boccaccini AR, Detsch Ret al., 2015, Evaluation of an alginate-gelatine crosslinked hydrogel for bioplotting, BIOFABRICATION, Vol: 7, ISSN: 1758-5082

Journal article

Chen Q, Li W, Goudouria O-M, Ding Y, Cabanas-Polo S, Boccaccini ARet al., 2015, Electrophoretic deposition of antibiotic loaded PHBV microsphere-alginate composite coating with controlled delivery potential, COLLOIDS AND SURFACES B-BIOINTERFACES, Vol: 130, Pages: 199-206, ISSN: 0927-7765

Journal article

Boccardi E, Belova IV, Murch GE, Boccaccini AR, Fiedler Tet al., 2015, Oxygen diffusion in marine-derived tissue engineering scaffolds, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, Vol: 26, ISSN: 0957-4530

Journal article

Porwal H, Estili M, Gruenewald A, Grasso S, Detsch R, Hu C, Sakka Y, Boccaccini AR, Reece MJet al., 2015, 45S5 Bioglass (R)-MWCNT composite: processing and bioactivity, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, Vol: 26, ISSN: 0957-4530

Journal article

Zaloga J, Janko C, Agarwal R, Nowak J, Mueller R, Boccaccini AR, Lee G, Odenbach S, Lyer S, Alexiou Cet al., 2015, Different Storage Conditions Influence Biocompatibility and Physicochemical Properties of Iron Oxide Nanoparticles, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol: 16, Pages: 9368-9384, ISSN: 1661-6596

Journal article

Chinnam RK, Boccaccini AR, Bernardo E, Epstein Het al., 2015, Glass-Ceramic Composites from Borosilicate Glass and Alumina-Rich Residues, INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY, Vol: 12, Pages: E19-E27, ISSN: 1546-542X

Journal article

Huang Z, Nooeaid P, Kohl B, Roether JA, Schubert DW, Meier C, Boccaccini AR, Godkin O, Ertel W, Arens S, Schulze-Tanzil Get al., 2015, Chondrogenesis of human bone marrow mesenchymal stromal cells in highly porous alginate-foams supplemented with chondroitin sulfate, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Vol: 50, Pages: 160-172, ISSN: 0928-4931

Journal article

Smeacetto F, De Miranda A, Polo SC, Molin S, Boccaccini D, Salvo M, Boccaccini ARet al., 2015, Electrophoretic deposition of Mn1.5Co1.5O4 on metallic interconnect and interaction with glass-ceramic sealant for solid oxide fuel cells application, JOURNAL OF POWER SOURCES, Vol: 280, Pages: 379-386, ISSN: 0378-7753

Journal article

Pishbin F, Cordero-Arias L, Cabanas-Polo S, Boccaccini ARet al., 2015, Bioactive polymer-calcium phosphate composite coatings by electrophoretic deposition, Surface Coating and Modification of Metallic Biomaterials, Pages: 359-377, ISBN: 9781782423034

© 2015 Elsevier Ltd. All rights reserved. Among the different approaches to overcome the common infections and loosening problems of orthopaedic metallic implants, the surface modification of the implant with bioactive coatings is gaining increasing attention, because the presence of a bioactive layer can enhance the bone-to-implant contact and reduce possible problems arising from infections. Furthermore, the combination of bioactive glasses (or ceramics) with biopolymers (so-called -soft-coatings-) leads to an improvement in the mechanical properties of the coatings, because the biopolymer acts as a glue, and therefore the sintering process that would lead to a loss in the bioactivity is avoided. A suitable technique to create these organic/inorganic composite coatings is electrophoretic deposition (EPD), which allows the co-deposition of inorganic particles with polymeric molecules and controls the thickness of the deposit by controlling the deposition voltage and time. Considering the similarities in the chemical composition of the mineral phase of the bone and calcium phosphate compounds, many different systems based on this material and in combination with biopolymers have been developed. AŠdescription on the EPD process and a compilation of these relevant systems are summarized in this chapter.

Book chapter

Cordero-Arias L, Boccaccini AR, Virtanen S, 2015, Electrochemical behavior of nanostructured TiO2/alginate composite coating on magnesium alloy AZ91D via electrophoretic deposition, SURFACE & COATINGS TECHNOLOGY, Vol: 265, Pages: 212-217, ISSN: 0257-8972

Journal article

Li W, Wang H, Ding Y, Scheithauer EC, Goudouri OM, Grünewald A, Detsch R, Agarwal S, Boccaccini ARet al., 2015, Antibacterial 45S5 Bioglass®-based scaffolds reinforced with genipin cross-linked gelatin for bone tissue engineering, Journal of Materials Chemistry B, Vol: 3, Pages: 3367-3378, ISSN: 2050-7518

45S5 Bioglass® (BG) scaffolds with high porosity (>90%) were coated with genipin cross-linked gelatin (GCG) and further incorporated with poly(p-xylyleneguanidine) hydrochloride (PPXG). The obtained GCG coated scaffolds maintained the high porosity and well interconnected pore structure. A 26-fold higher compressive strength was provided to 45S5 BG scaffolds by GCG coating, which slightly retarded but did not inhibit the in vitro bioactivity of 45S5 BG scaffolds in SBF. Moreover, the scaffolds were made antibacterial against both Gram-positive and Gram-negative bacteria by using polyguanidine, i.e. PPXG, in this study. Osteoblast-like cells (MG-63) were seeded onto PPXG and GCG coated scaffolds. PPXG was biocompatible with MG-63 cells at a low concentration (10 μg mL−1). MG-63 cells were shown to attach and spread on both uncoated and GCG coated scaffolds, and the mitochondrial activity measurement indicated that GCG coating had no negative influence on the cell proliferation behavior of MG-63 cells. The developed novel antibacterial bioactive 45S5 BG-based composite scaffolds with improved mechanical properties are promising candidates for bone tissue engineering.

Journal article

Francis A, Yang Y, Virtanen S, Boccaccini ARet al., 2015, Iron and iron-based alloys for temporary cardiovascular applications, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, Vol: 26, ISSN: 0957-4530

Journal article

Dignatici M, Chavez-Valdez A, Andreola F, Siligardi C, Boccaccini ARet al., 2015, Effect of additives on the dispersion and electrophoretic deposition of highly diluted enamel suspensions, InterCeram: International Ceramic Review, Vol: 64, Pages: 45-48, ISSN: 0020-5214

This work examines the rheological behaviour of aqueous highly diluted suspensions (1 mass-%) to identify additives that may improve the application of vitreous enamel coatings by electrophoretic deposition (EPD). Slurries for EPD were prepared by ball milling frit glass in water with suspending agents. The effect of different additives in the solids concentration range from 0.2 to 2.0 mass-% on the rheological properties of coating solutions was investigated using rotational rheometry and zeta potential measurements. Different sedimentation times were observed for the tested dispersant, binder and coagulator additives. Densicer, an organic-inorganic mix additive, showed the best properties in terms of suspension stability. The high zeta potential measured with this product confirms its potential suitability as a suspension additive for vitreous enamel coatings applied by EPD.

Journal article

Detsch R, Alles S, Hum J, Westenberger P, Sieker F, Heusinger D, Kasper C, Boccaccini ARet al., 2015, Osteogenic differentiation of umbilical cord and adipose derived stem cells onto highly porous 45S5 Bioglass (R)-based scaffolds, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol: 103, Pages: 1029-1037, ISSN: 1549-3296

Journal article

Verne E, Ferraris S, Cassinelli C, Boccaccini ARet al., 2015, Surface functionalization of Bioglass (R) with alkaline phosphatase, SURFACE & COATINGS TECHNOLOGY, Vol: 264, Pages: 132-139, ISSN: 0257-8972

Journal article

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