Imperial College London

Professor Aldo R. Boccaccini

Faculty of EngineeringDepartment of Materials

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 6731a.boccaccini

 
 
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Location

 

210Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

1189 results found

Rath SN, Brandl A, Hiller D, Hoppe A, Gbureck U, Horch RE, Boccaccini AR, Kneser Uet al., 2014, Bioactive Copper-Doped Glass Scaffolds Can Stimulate Endothelial Cells in Co-Culture in Combination with Mesenchymal Stem Cells, PLOS ONE, Vol: 9, ISSN: 1932-6203

Journal article

Detsch R, Sarker B, Zehnder T, Boccaccini AR, Douglasa TELet al., 2014, Additive manufacturing of cell-loaded alginate enriched with alkaline phosphatase for bone tissue engineering application, BioNanoMaterials, Vol: 15, Pages: 79-87, ISSN: 2193-0651

Hydrogels are gaining interest as scaffolds for bone tissue regeneration due to ease of incorporation of cells and biological molecules such as enzymes. Mineralization of hydrogels, desirable for bone tissue regeneration applications, may be achieved enzymatically by incorporation of alkaline phosphatase (ALP). Additive manufacturing techniques such as bioplotting enable the layer-by-layer creation of three-dimensional hydrogel scaffolds with highly defined geometry and internal architecture. In this study, we present a novel method to produce macroporous hydrogel scaffolds in combination with cell-loaded capsule-containing struts by 3D bioplotting. This approach enables loading of the capsules and strut phases with different cells and/or bioactive substances and hence makes compartmentalization within a scaffold possible. 3D porous alginate scaffolds enriched with ALP and MG-63 osteoblast-like cells were produced by bioplotting struts of alginate which were loaded with pre-fabricated alginate capsules. Two combinations were compared, namely ALP in the struts and cells in the capsules and vice-versa. Both combinations were cytocompatible for cells and mineralization of scaffolds could be detected in both cases, according to an OsteoImage staining. ALP had no adverse effect on cytocompatibility and enhanced mitochondrial activity.

Journal article

Yao Q, Nooeaid P, Detsch R, Roether JA, Dong Y, Goudouri O-M, Schubert DW, Boccaccini ARet al., 2014, Bioglass (R)/chitosan-polycaprolactone bilayered composite scaffolds intended for osteochondral tissue engineering, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol: 102, Pages: 4510-4518, ISSN: 1549-3296

Journal article

Li W, Pastrama M-I, Ding Y, Zheng K, Hellmich C, Boccaccini ARet al., 2014, Ultrasonic elasticity determination of 45S5 Bioglass (R)-based scaffolds: Influence of polymer coating and crosslinking treatment, JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, Vol: 40, Pages: 85-94, ISSN: 1751-6161

Journal article

Chavez-Valdez A, Arizmendi-Morquecho A, Moreno KJ, Roether JA, Kaschta J, Boccaccini ARet al., 2014, TiO2-PLLA nanocomposite coatings and free-standing films by a combined electrophoretic deposition-dip coating process, COMPOSITES PART B-ENGINEERING, Vol: 67, Pages: 256-261, ISSN: 1359-8368

Journal article

Nooeaid P, Li W, Roether JA, Mourino V, Goudouri O-M, Schubert DW, Boccaccini ARet al., 2014, Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating, BIOINTERPHASES, Vol: 9, ISSN: 1934-8630

Journal article

Goudouri O-M, Kontonasaki E, Chrissafis K, Zinn K, Hoppe A, Detsch R, Paraskevopoulos KM, Boccaccini ARet al., 2014, Towards the synthesis of an Mg-containing silicate glass-ceramic to be used as a scaffold for cementum/alveolar bone regeneration, CERAMICS INTERNATIONAL, Vol: 40, Pages: 16287-16298, ISSN: 0272-8842

Journal article

Lopez Calvo V, Vicent Cabedo M, Bannier E, Canas Recacha E, Boccaccini AR, Arias LC, Sanchez Vilches Eet al., 2014, 45S5 bioactive glass coatings by atmospheric plasma spraying obtained from feedstocks prepared by different routes, JOURNAL OF MATERIALS SCIENCE, Vol: 49, Pages: 7933-7942, ISSN: 0022-2461

Journal article

Hutmacher DW, Boccaccini AR, 2014, Editorial: Manufacturing meets biofabrication: Part 1, BioNanoMaterials, Vol: 15, ISSN: 2193-0651

Journal article

Detsch R, Stoor P, Gruenewald A, Roether JA, Lindfors NC, Boccaccini ARet al., 2014, Increase in VEGF secretion from human fibroblast cells by bioactive glass S53P4 to stimulate angiogenesis in bone, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol: 102, Pages: 4055-4061, ISSN: 1549-3296

Journal article

Bertolla L, Dlouhy I, Boccaccini AR, 2014, Preparation and characterization of Bioglass (R)-based scaffolds reinforced by poly-vinyl alcohol/microfibrillated cellulose composite coating, JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, Vol: 34, Pages: 3379-3387, ISSN: 0955-2219

Journal article

Qazi TH, Rai R, Boccaccini AR, 2014, Tissue engineering of electrically responsive tissues using polyaniline based polymers: A review, BIOMATERIALS, Vol: 35, Pages: 9068-9086, ISSN: 0142-9612

Journal article

Fiedler T, Belova IV, Murch GE, Poologasundarampillai G, Jones JR, Roether JA, Boccaccini ARet al., 2014, A comparative study of oxygen diffusion in tissue engineering scaffolds, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, Vol: 25, Pages: 2573-2578, ISSN: 0957-4530

Journal article

Patra C, Boccaccini AR, Engel FB, 2014, Vascularisation for cardiac tissue engineering: the extracellular matrix., Thrombosis and Haemostasis, Vol: 113, Pages: 532-547, ISSN: 0340-6245

Cardiovascular diseases present a major socio-economic burden. One major problem underlying most cardiovascular and congenital heart diseases is the irreversible loss of contractile heart muscle cells, the cardiomyocytes. To reverse damage incurred by myocardial infarction or by surgical correction of cardiac malformations, the loss of cardiac tissue with a thickness of a few millimetres needs to be compensated. A promising approach to this issue is cardiac tissue engineering. In this review we focus on the problem of in vitro vascularisation as implantation of cardiac patches consisting of more than three layers of cardiomyocytes (> 100 µm thick) already results in necrosis. We explain the need for vascularisation and elaborate on the importance to include non-myocytes in order to generate functional vascularised cardiac tissue. We discuss the potential of extracellular matrix molecules in promoting vascularisation and introduce nephronectin as an example of a new promising candidate. Finally, we discuss current biomaterial-based approaches including micropatterning, electrospinning, 3D micro-manufacturing technology and porogens. Collectively, the current literature supports the notion that cardiac tissue engineering is a realistic option for future treatment of paediatric and adult patients with cardiac disease.

Journal article

Clavijo S, Membrives F, Boccaccini AR, Santillan MJet al., 2014, Characterization of Polyetheretherketone Particle Suspensions for Electrophoretic Deposition, JOURNAL OF APPLIED POLYMER SCIENCE, Vol: 131, ISSN: 0021-8995

Journal article

Li W, Garmendia N, De Larraya UP, Ding Y, Detsch R, Grünewald A, Roether JA, Schubert DW, Boccaccini ARet al., 2014, 45S5 bioactive glass-based scaffolds coated with cellulose nanowhiskers for bone tissue engineering, RSC Advances, Vol: 4, Pages: 56156-56164, ISSN: 2046-2069

Highly porous 45S5 bioactive glass-based scaffolds prepared by foam replication method were coated with cellulose nanowhiskers by dip coating method. The obtained cellulose nanowhisker-coated scaffolds retained the high porosity and interconnected pore structure. The cellulose coating improved the mechanical properties of the scaffolds and did not hinder their bioactivity in simulated body fluid. In vitro biocompatibility assessment was carried out by qualitative evaluation of the morphology of osteoblast-like cells (MG-63) seeded onto the scaffolds. The cells were shown to attach and spread on both uncoated scaffolds and cellulose nanowhisker-coated scaffolds, thus cellulose nanowhisker coating seems to have no negative influence on the behavior of MG-63 cells. The obtained bioactive and biocompatible composite scaffolds represent promising candidates for bone tissue engineering applications.

Journal article

Milkovic L, Hoppe A, Detsch R, Boccaccini AR, Zarkovic Net al., 2014, Effects of Cu-doped 45S5 bioactive glass on the lipid peroxidation-associated growth of human osteoblast-like cells in vitro, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol: 102, Pages: 3556-3561, ISSN: 1549-3296

Journal article

Sarker B, Singh R, Silva R, Roether JA, Kaschta J, Detsch R, Schubert DW, Cicha I, Boccaccini ARet al., 2014, Evaluation of Fibroblasts Adhesion and Proliferation on Alginate-Gelatin Crosslinked Hydrogel, PLOS ONE, Vol: 9, ISSN: 1932-6203

Journal article

Kuenzel C, Li L, Vandeperre L, Boccaccini AR, Cheeseman CRet al., 2014, Influence of sand on the mechanical properties of metakaolin geopolymers, CONSTRUCTION AND BUILDING MATERIALS, Vol: 66, Pages: 442-446, ISSN: 0950-0618

Journal article

Silva R, Bulut B, Roether JA, Kaschta J, Schubert DW, Boccaccini ARet al., 2014, Sonochemical processing and characterization of composite materials based on soy protein and alginate containing micron-sized bioactive glass particles, JOURNAL OF MOLECULAR STRUCTURE, Vol: 1073, Pages: 87-96, ISSN: 0022-2860

Journal article

Naseri S, Diba M, Golkar S, Boccaccini AR, Taylor RNKet al., 2014, Fabrication of gold-nanoshell/polycaprolactonecomposite films with high electrical conductivity, MATERIALS LETTERS, Vol: 130, Pages: 164-167, ISSN: 0167-577X

Journal article

Lourdes Ramiro-Gutierrez M, Will J, Boccaccini AR, Diaz-Cuenca Aet al., 2014, Reticulated bioactive scaffolds with improved textural properties for bone tissue engineering: Nanostructured surfaces and porosity, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol: 102, Pages: 2982-2992, ISSN: 1549-3296

Journal article

Belli R, Kreppel S, Petschelt A, Hornberger H, Boccaccini AR, Lohbauer Uet al., 2014, Strengthening of dental adhesives via particle reinforcement, JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, Vol: 37, Pages: 100-108, ISSN: 1751-6161

Journal article

Frank MA, Boccaccini AR, Virtanen S, 2014, A facile and scalable method to produce superhydrophic stainless steel surface, APPLIED SURFACE SCIENCE, Vol: 311, Pages: 753-757, ISSN: 0169-4332

Journal article

Unterweger H, Tietze R, Janko C, Zaloga J, Lyer S, Duerr S, Taccardi N, Goudouri O-M, Hoppe A, Eberbeck D, Schubert DW, Boccaccini AR, Alexiou Cet al., 2014, Development and characterization of magnetic iron oxide nanoparticles with a cisplatin-bearing polymer coating for targeted drug delivery, INTERNATIONAL JOURNAL OF NANOMEDICINE, Vol: 9, Pages: 3659-3676, ISSN: 1178-2013

Journal article

Silva R, Fabry B, Boccaccini AR, 2014, Fibrous protein-based hydrogels for cell encapsulation, BIOMATERIALS, Vol: 35, Pages: 6727-6738, ISSN: 0142-9612

Journal article

Li W, Ding Y, Rai R, Roether JA, Schubert DW, Boccaccini ARet al., 2014, Preparation and characterization of PHBV microsphere/45S5 bioactive glass composite scaffolds with vancomycin releasing function, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Vol: 41, Pages: 320-328, ISSN: 0928-4931

Journal article

Douglas TEL, Piwowarczyk W, Pamula E, Liskova J, Schaubroeck D, Leeuwenburgh SCG, Brackman G, Balcaen L, Detsch R, Declercq H, Cholewa-Kowalska K, Dokupil A, Cuijpers VMJI, Vanhaecke F, Cornelissen R, Coenye T, Boccaccini AR, Dubruel Pet al., 2014, Injectable self-gelling composites for bone tissue engineering based on gellan gum hydrogel enriched with different bioglasses, BIOMEDICAL MATERIALS, Vol: 9, ISSN: 1748-6041

Journal article

Chatzistavrou X, Fenno JC, Faulk D, Badylak S, Kasuga T, Boccaccini AR, Papagerakis Pet al., 2014, Fabrication and characterization of bioactive and antibacterial composites for dental applications, ACTA BIOMATERIALIA, Vol: 10, Pages: 3723-3732, ISSN: 1742-7061

Journal article

Goudouri O-M, Kontonasaki E, Lohbauer U, Boccaccini ARet al., 2014, Antibacterial properties of metal and metalloid ions in chronic periodontitis and peri-implantitis therapy, ACTA BIOMATERIALIA, Vol: 10, Pages: 3795-3810, ISSN: 1742-7061

Journal article

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