Imperial College London

Professor Aldo R. Boccaccini

Faculty of EngineeringDepartment of Materials

Visiting Professor



+44 (0)20 7594 6731a.boccaccini




210Royal School of MinesSouth Kensington Campus






BibTex format

author = {Goudouri, OM and Vogel, C and Grünewald, A and Detsch, R and Kontonasaki, E and Boccaccini, AR},
doi = {10.1177/0885328215584887},
journal = {Journal of Biomaterials Applications},
pages = {740--749},
title = {Sol-gel processing of novel bioactive Mg-containing silicate scaffolds for alveolar bone regeneration.},
url = {},
volume = {30},
year = {2016}

RIS format (EndNote, RefMan)

AB - Periodontal tissue regeneration is an important application area of biomaterials, given the large proportion of the population affected by periodontal diseases like periodontitis. The aim of this study was the synthesis of a novel porous bioceramic scaffold in the SiO2-CaO-MgO system with specific properties targeted for alveolar bone tissue regeneration using a modification of the traditional foam replica technique. Since bioceramic scaffolds are considered brittle, scaffolds were also coated with gelatin in order to increase their mechanical stability. Gelatin was chosen for its biocompatibility, biodegradability, low-cost, and low immunogenicity. However, gelatin degrades very fast in water solutions. For this reason, two different cross-linking agents were evaluated. Genipin, a non-toxic gardenia extract and the chemical compound 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) in combination with N-hydroxysuccinimide (NHS), which is also considered non-toxic. The results of the investigation indicated that all scaffolds presented an open, interconnected porosity and pores' sizes in the range of 300-600 μm, fast apatite-forming ability, biocompatibility, and suitable mechanical stability.
AU - Goudouri,OM
AU - Vogel,C
AU - Grünewald,A
AU - Detsch,R
AU - Kontonasaki,E
AU - Boccaccini,AR
DO - 10.1177/0885328215584887
EP - 749
PY - 2016///
SN - 1530-8022
SP - 740
TI - Sol-gel processing of novel bioactive Mg-containing silicate scaffolds for alveolar bone regeneration.
T2 - Journal of Biomaterials Applications
UR -
VL - 30
ER -