Imperial College London

Professor Aldo R. Boccaccini

Faculty of EngineeringDepartment of Materials

Visiting Professor



+44 (0)20 7594 6731a.boccaccini




210Royal School of MinesSouth Kensington Campus






BibTex format

author = {Balasubramanian, P and Grünewald, A and Detsch, R and Hupa, L and Jokic, B and Tallia, F and Solanki, AK and Jones, JR and Boccaccini, AR},
doi = {10.1111/ijag.12206},
journal = {International Journal of Applied Glass Science},
pages = {206--215},
title = {Ion Release, Hydroxyapatite Conversion, and Cytotoxicity of Boron-containing Bioactive Glass Scaffolds},
url = {},
volume = {7},
year = {2016}

RIS format (EndNote, RefMan)

AB - We report the development and characterization of boron-releasing highly porous three-dimensional bioactive glass (BG) scaffolds fabricated by the foam replica technique. Three types of bioactive glasses with (wt%) 0.2%, 12.5%, 25% B2O3, and related varying SiO2 contents (wt%): 50%, 37.5%, and 25%, were investigated. The well-known 13-93 (silicate) and 13-93B3 (borate) (in wt% - 56.6% B2O3, 5.5% Na2O, 11.1% K2O, 4.6% MgO, 18.5% CaO, 3.7% P2O5) BGs were used as controls to study the influence of the presence of boron on the mechanical properties, surface reactivity, and cytotoxicity of scaffolds. Surface morphology and surface properties of the BG scaffolds were measured. X-ray diffraction (XRD) analyses showed that the scaffolds of all five compositions were amorphous. The scaffolds with 12.5 wt% B2O3 exhibited satisfactory compressive strength in the range of 1-2 MPa. A dissolution study in cell culture medium was carried out, and ion release profiles, and apatite formation of the scaffolds were assessed. The cytotoxicity of the scaffolds was evaluated using a stromal cell line (ST2). Cells were found to attach and spread well on the scaffolds' surfaces. We conclude that borosilicate scaffolds containing 12.5 wt% B2O3 provide the best combination of properties, including relatively high mechanical strength, apatite formation, and cytocompatibility, and thus, they are promising candidates for bone tissue engineering.
AU - Balasubramanian,P
AU - Grünewald,A
AU - Detsch,R
AU - Hupa,L
AU - Jokic,B
AU - Tallia,F
AU - Solanki,AK
AU - Jones,JR
AU - Boccaccini,AR
DO - 10.1111/ijag.12206
EP - 215
PY - 2016///
SN - 2041-1286
SP - 206
TI - Ion Release, Hydroxyapatite Conversion, and Cytotoxicity of Boron-containing Bioactive Glass Scaffolds
T2 - International Journal of Applied Glass Science
UR -
VL - 7
ER -