Imperial College London

Professor Aldo R. Boccaccini

Faculty of EngineeringDepartment of Materials

Visiting Professor



+44 (0)20 7594 6731a.boccaccini




210Royal School of MinesSouth Kensington Campus






BibTex format

author = {Hoppe, A and Boccaccini, AR},
booktitle = {RSC Smart Materials},
doi = {10.1039/9781782622017-00362},
pages = {362--392},
title = {Chapter 16: Bioactive Glasses as Carriers of Therapeutic Ions and the Biological Implications},
url = {},
year = {2017}

RIS format (EndNote, RefMan)

AB - © The Royal Society of Chemistry 2017. In the last few decades bioactive glasses (BGs) have been widely considered for bone tissue engineering applications due to their bioactivity and their osteogenic effects. The available scientific evidence suggests that ionic dissolution products (at a critical concentration) released during the degradation of the BG matrix induce osteogenic gene expression hence stimulating the bone regeneration process. Moreover, adding bioactive metallic ions (e.g. boron, copper, cobalt, lithium silver, zinc and strontium) to silicate as well as to phosphate and borate glasses has emerged as a promising route to develop novel BG formulations with specific therapeutic functionalities, including antibacterial, angiogenic, osteogenic and wound healing. The degradation behaviour of BGs can be tailored by adjusting the glass chemistry, making these biomaterials suitable carrier systems for controlled therapeutic ion release. This book chapter summarizes the fundamental aspects of the effect of ionic dissolution products released from BGs on osteogenesis and angiogenesis, also discussing novel BG compositions containing inorganic therapeutic agents. In vitro cellular as well as in vivo responses to specific therapeutic ions are discussed.
AU - Hoppe,A
AU - Boccaccini,AR
DO - 10.1039/9781782622017-00362
EP - 392
PY - 2017///
SP - 362
TI - Chapter 16: Bioactive Glasses as Carriers of Therapeutic Ions and the Biological Implications
T1 - RSC Smart Materials
UR -
ER -