Publications
1189 results found
Detsch R, Sarker B, Zehnder T, et al., 2014, Additive manufacturing of cell-loaded alginate enriched with alkaline phosphatase for bone tissue engineering application, BioNanoMaterials, Vol: 15, Pages: 79-87, ISSN: 2193-0651
Hydrogels are gaining interest as scaffolds for bone tissue regeneration due to ease of incorporation of cells and biological molecules such as enzymes. Mineralization of hydrogels, desirable for bone tissue regeneration applications, may be achieved enzymatically by incorporation of alkaline phosphatase (ALP). Additive manufacturing techniques such as bioplotting enable the layer-by-layer creation of three-dimensional hydrogel scaffolds with highly defined geometry and internal architecture. In this study, we present a novel method to produce macroporous hydrogel scaffolds in combination with cell-loaded capsule-containing struts by 3D bioplotting. This approach enables loading of the capsules and strut phases with different cells and/or bioactive substances and hence makes compartmentalization within a scaffold possible. 3D porous alginate scaffolds enriched with ALP and MG-63 osteoblast-like cells were produced by bioplotting struts of alginate which were loaded with pre-fabricated alginate capsules. Two combinations were compared, namely ALP in the struts and cells in the capsules and vice-versa. Both combinations were cytocompatible for cells and mineralization of scaffolds could be detected in both cases, according to an OsteoImage staining. ALP had no adverse effect on cytocompatibility and enhanced mitochondrial activity.
Lopez Calvo V, Vicent Cabedo M, Bannier E, et al., 2014, 45S5 bioactive glass coatings by atmospheric plasma spraying obtained from feedstocks prepared by different routes, JOURNAL OF MATERIALS SCIENCE, Vol: 49, Pages: 7933-7942, ISSN: 0022-2461
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- Citations: 20
Nooeaid P, Li W, Roether JA, et al., 2014, Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating, BIOINTERPHASES, Vol: 9, ISSN: 1934-8630
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- Citations: 25
Li W, Pastrama M-I, Ding Y, et al., 2014, Ultrasonic elasticity determination of 45S5 Bioglass®-based scaffolds: Influence of polymer coating and crosslinking treatment, JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, Vol: 40, Pages: 85-94, ISSN: 1751-6161
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- Citations: 20
Goudouri O-M, Kontonasaki E, Chrissafis K, et al., 2014, Towards the synthesis of an Mg-containing silicate glass-ceramic to be used as a scaffold for cementum/alveolar bone regeneration, CERAMICS INTERNATIONAL, Vol: 40, Pages: 16287-16298, ISSN: 0272-8842
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- Citations: 22
Yao Q, Nooeaid P, Detsch R, et al., 2014, Bioglass®/chitosan-polycaprolactone bilayered composite scaffolds intended for osteochondral tissue engineering, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol: 102, Pages: 4510-4518, ISSN: 1549-3296
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- Citations: 39
Chavez-Valdez A, Arizmendi-Morquecho A, Moreno KJ, et al., 2014, TiO<sub>2</sub>-PLLA nanocomposite coatings and free-standing films by a combined electrophoretic deposition-dip coating process, COMPOSITES PART B-ENGINEERING, Vol: 67, Pages: 256-261, ISSN: 1359-8368
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- Citations: 7
Fiedler T, Belova IV, Murch GE, et al., 2014, A comparative study of oxygen diffusion in tissue engineering scaffolds, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, Vol: 25, Pages: 2573-2578, ISSN: 0957-4530
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- Citations: 23
Bertolla L, Dlouhy I, Boccaccini AR, 2014, Preparation and characterization of Bioglass®-based scaffolds reinforced by poly-vinyl alcohol/microfibrillated cellulose composite coating, JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, Vol: 34, Pages: 3379-3387, ISSN: 0955-2219
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- Citations: 12
Detsch R, Stoor P, Gruenewald A, et al., 2014, Increase in VEGF secretion from human fibroblast cells by bioactive glass S53P4 to stimulate angiogenesis in bone, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol: 102, Pages: 4055-4061, ISSN: 1549-3296
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- Citations: 65
Qazi TH, Rai R, Boccaccini AR, 2014, Tissue engineering of electrically responsive tissues using polyaniline based polymers: A review, BIOMATERIALS, Vol: 35, Pages: 9068-9086, ISSN: 0142-9612
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- Citations: 295
Patra C, Boccaccini AR, Engel FB, 2014, Vascularisation for cardiac tissue engineering: the extracellular matrix., Thrombosis and Haemostasis, Vol: 113, Pages: 532-547, ISSN: 0340-6245
Cardiovascular diseases present a major socio-economic burden. One major problem underlying most cardiovascular and congenital heart diseases is the irreversible loss of contractile heart muscle cells, the cardiomyocytes. To reverse damage incurred by myocardial infarction or by surgical correction of cardiac malformations, the loss of cardiac tissue with a thickness of a few millimetres needs to be compensated. A promising approach to this issue is cardiac tissue engineering. In this review we focus on the problem of in vitro vascularisation as implantation of cardiac patches consisting of more than three layers of cardiomyocytes (> 100 µm thick) already results in necrosis. We explain the need for vascularisation and elaborate on the importance to include non-myocytes in order to generate functional vascularised cardiac tissue. We discuss the potential of extracellular matrix molecules in promoting vascularisation and introduce nephronectin as an example of a new promising candidate. Finally, we discuss current biomaterial-based approaches including micropatterning, electrospinning, 3D micro-manufacturing technology and porogens. Collectively, the current literature supports the notion that cardiac tissue engineering is a realistic option for future treatment of paediatric and adult patients with cardiac disease.
Clavijo S, Membrives F, Boccaccini AR, et al., 2014, Characterization of Polyetheretherketone Particle Suspensions for Electrophoretic Deposition, JOURNAL OF APPLIED POLYMER SCIENCE, Vol: 131, ISSN: 0021-8995
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- Citations: 14
Li W, Garmendia N, De Larraya UP, et al., 2014, 45S5 bioactive glass-based scaffolds coated with cellulose nanowhiskers for bone tissue engineering, RSC Advances, Vol: 4, Pages: 56156-56164, ISSN: 2046-2069
Highly porous 45S5 bioactive glass-based scaffolds prepared by foam replication method were coated with cellulose nanowhiskers by dip coating method. The obtained cellulose nanowhisker-coated scaffolds retained the high porosity and interconnected pore structure. The cellulose coating improved the mechanical properties of the scaffolds and did not hinder their bioactivity in simulated body fluid. In vitro biocompatibility assessment was carried out by qualitative evaluation of the morphology of osteoblast-like cells (MG-63) seeded onto the scaffolds. The cells were shown to attach and spread on both uncoated scaffolds and cellulose nanowhisker-coated scaffolds, thus cellulose nanowhisker coating seems to have no negative influence on the behavior of MG-63 cells. The obtained bioactive and biocompatible composite scaffolds represent promising candidates for bone tissue engineering applications.
Milkovic L, Hoppe A, Detsch R, et al., 2014, Effects of Cu-doped 45S5 bioactive glass on the lipid peroxidation-associated growth of human osteoblast-like cells <i>in vitro</i>, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol: 102, Pages: 3556-3561, ISSN: 1549-3296
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- Citations: 41
Sarker B, Singh R, Silva R, et al., 2014, Evaluation of Fibroblasts Adhesion and Proliferation on Alginate-Gelatin Crosslinked Hydrogel, PLOS ONE, Vol: 9, ISSN: 1932-6203
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- Citations: 175
Gmeiner R, Mitteramskogler G, Stampfl J, et al., 2014, Stereolithographic Ceramic Manufacturing of High Strength Bioactive Glass, INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY, Vol: 12, Pages: 38-45, ISSN: 1546-542X
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- Citations: 64
Kuenzel C, Li L, Vandeperre L, et al., 2014, Influence of sand on the mechanical properties of metakaolin geopolymers, CONSTRUCTION AND BUILDING MATERIALS, Vol: 66, Pages: 442-446, ISSN: 0950-0618
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- Citations: 65
Silva R, Bulut B, Roether JA, et al., 2014, Sonochemical processing and characterization of composite materials based on soy protein and alginate containing micron-sized bioactive glass particles, JOURNAL OF MOLECULAR STRUCTURE, Vol: 1073, Pages: 87-96, ISSN: 0022-2860
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- Citations: 25
Naseri S, Diba M, Golkar S, et al., 2014, Fabrication of gold-nanoshell/polycaprolactonecomposite films with high electrical conductivity, MATERIALS LETTERS, Vol: 130, Pages: 164-167, ISSN: 0167-577X
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- Citations: 5
Belli R, Kreppel S, Petschelt A, et al., 2014, Strengthening of dental adhesives via particle reinforcement, JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, Vol: 37, Pages: 100-108, ISSN: 1751-6161
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- Citations: 53
Lourdes Ramiro-Gutierrez M, Will J, Boccaccini AR, et al., 2014, Reticulated bioactive scaffolds with improved textural properties for bone tissue engineering: Nanostructured surfaces and porosity, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol: 102, Pages: 2982-2992, ISSN: 1549-3296
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- Citations: 19
Frank MA, Boccaccini AR, Virtanen S, 2014, A facile and scalable method to produce superhydrophic stainless steel surface, APPLIED SURFACE SCIENCE, Vol: 311, Pages: 753-757, ISSN: 0169-4332
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- Citations: 26
Unterweger H, Tietze R, Janko C, et al., 2014, Development and characterization of magnetic iron oxide nanoparticles with a cisplatin-bearing polymer coating for targeted drug delivery, INTERNATIONAL JOURNAL OF NANOMEDICINE, Vol: 9, Pages: 3659-3676, ISSN: 1178-2013
Li W, Ding Y, Rai R, et al., 2014, Preparation and characterization of PHBV microsphere/45S5 bioactive glass composite scaffolds with vancomycin releasing function, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Vol: 41, Pages: 320-328, ISSN: 0928-4931
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- Citations: 50
Grigore A, Sarker B, Fabry B, et al., 2014, Behavior of Encapsulated MG-63 Cells in RGD and Gelatine-Modified Alginate Hydrogels, TISSUE ENGINEERING PART A, Vol: 20, Pages: 2140-2150, ISSN: 1937-3341
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- Citations: 90
Chatzistavrou X, Fenno JC, Faulk D, et al., 2014, Fabrication and characterization of bioactive and antibacterial composites for dental applications, ACTA BIOMATERIALIA, Vol: 10, Pages: 3723-3732, ISSN: 1742-7061
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- Citations: 81
Silva R, Fabry B, Boccaccini AR, 2014, Fibrous protein-based hydrogels for cell encapsulation, BIOMATERIALS, Vol: 35, Pages: 6727-6738, ISSN: 0142-9612
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- Citations: 106
Goudouri O-M, Kontonasaki E, Lohbauer U, et al., 2014, Antibacterial properties of metal and metalloid ions in chronic periodontitis and peri-implantitis therapy, ACTA BIOMATERIALIA, Vol: 10, Pages: 3795-3810, ISSN: 1742-7061
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- Citations: 86
Douglas TEL, Piwowarczyk W, Pamula E, et al., 2014, Injectable self-gelling composites for bone tissue engineering based on gellan gum hydrogel enriched with different bioglasses, BIOMEDICAL MATERIALS, Vol: 9, ISSN: 1748-6041
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- Citations: 52
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