Imperial College London
Alternate

Professor Aldo R. Boccaccini

Faculty of Engineering, Department of Materials

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 6731a.boccaccini

 
 
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Location

 

210Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Haro:2017:10.3390/ma10070740,
author = {Haro, Durand LA and Vargas, GE and Vera-Mesones, R and Baldi, A and Zago, MP and Fanovich, MA and Boccaccini, AR and Gorustovich, A},
doi = {10.3390/ma10070740},
journal = {Materials},
title = {In Vitro Human Umbilical Vein Endothelial Cells Response to Ionic Dissolution Products from Lithium-Containing 45S5 Bioactive Glass},
url = {http://dx.doi.org/10.3390/ma10070740},
volume = {10},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Since lithium (Li+) plays roles in angiogenesis, the localized and controlled release of Li+ ions from bioactive glasses (BGs) represents a promising alternative therapy for the regeneration and repair of tissues with a high degree of vascularization. Here, microparticles from a base 45S5 BG composition containing (wt %) 45% SiO2, 24.5% Na2O, 24.5% CaO, and 6% P2O5, in which Na2O was partially substituted by 5% Li2O (45S5.5Li), were obtained. The results demonstrate that human umbilical vein endothelial cells (HUVECs) have greater migratory and proliferative response and ability to form tubules in vitro after stimulation with the ionic dissolution products (IDPs) of the 45S5.5Li BG. The results also show the activation of the canonical Wnt/β-catenin pathway and the increase in expression of proangiogenic cytokines insulin like growth factor 1 (IGF1) and transforming growth factor beta (TGFβ). We conclude that the IDPs of 45S5.5Li BG would act as useful inorganic agents to improve tissue repair and regeneration, ultimately stimulating HUVECs behavior in the absence of exogenous growth factors.
AU  - Haro,Durand LA
AU  - Vargas,GE
AU  - Vera-Mesones,R
AU  - Baldi,A
AU  - Zago,MP
AU  - Fanovich,MA
AU  - Boccaccini,AR
AU  - Gorustovich,A
DO  - 10.3390/ma10070740
PY  - 2017///
SN  - 1996-1944
TI  - In Vitro Human Umbilical Vein Endothelial Cells Response to Ionic Dissolution Products from Lithium-Containing 45S5 Bioactive Glass
T2  - Materials
UR  - http://dx.doi.org/10.3390/ma10070740
UR  - http://hdl.handle.net/10044/1/54063
VL  - 10
ER  -
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