Publications
597 results found
Osborne OJ, Boobis A, Botham P, et al., 2024, The new normal chemical landscape: the future of risk assessment toward optimum consumer safety., Toxicol Res (Camb), Vol: 13, ISSN: 2045-452X
The further optimization of consumer safety through risk assessment of chemicals present in food will require adaptability and flexibility to utilize the accelerating developments in safety science and technology. New Approach Methodologies (NAMs) are gaining traction as a systematic approach to support informed decision making in chemical risk assessment. The vision is to be able to predict risk more accurately, rapidly and efficiently. The opportunity exists now to use these approaches which requires a strategy to translate the science into future regulatory implementation. Here we discuss new insights obtained from three recent workshops on how to translate the science into future regulatory implementation. To assist the UK in this endeavor, the Food Standards Agency (FSA) and the scientific advisory committee on chemical toxicity (COT) have been developing a roadmap. In addition, we discuss how these new insights fit into the bigger picture of the new chemical landscape for better consumer safety and the importance of international harmonization.
Löwik MR, Astrup A, Boobis AR, et al., 2024, Risk assessment of nutrients: There must be a threshold for their effects., Regul Toxicol Pharmacol, Vol: 146
Nutrients serve physiological functions in a dose-dependent manner and that needs to be recognized in risk assessment. An example of the consequences of not properly considering this can be seen in a recent assessment by the European Food Safety Authority (EFSA). EFSA concluded in 2022 that the intake of added and free sugars should be "as low as possible in the context of a nutritionally adequate diet". That conclusion of EFSA is based on the effects on two surrogate endpoints for an adverse effect found in randomized controlled trials with high sugars intake levels: fasting glucose and fasting triglycerides. The lowest intake levels in these trials were around 10 energy% and at this intake level there were no adverse effects on the two outcomes. This indicates that the adverse effects of sugars have an observable threshold value for these two endpoints. The most appropriate interpretation from the vast amount of data is that currently no definitive conclusion can be drawn on the tolerable upper intake level for dietary sugars. Therefore, EFSA's own guidance would lead to the conclusion that the available data do not allow the setting of an upper limit for added sugars and hence, that more robust data are required to identify the threshold value for intake of sugars.
Dyson E, Helbig R, Avermaete T, et al., 2023, Impacts of the Ukraine-Russia Conflict on the Global Food Supply Chain and Building Future ResilienceDie Auswirkungen des Ukraine-Russland-Konflikts auf die globale Lebensmittelwarenkette und der Aufbau von kunftiger Resilienz, EUROCHOICES, Vol: 22, Pages: 14-19, ISSN: 1478-0917
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- Citations: 2
Escher SE, Felter SP, Hollnagel H, et al., 2023, Workshop Report on the Evaluation of the Updated and Expanded Carcinogen Database to Support Derivation of Threshold of Toxicological Concern Values for DNA-Reactive Carcinogens, ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, Vol: 40, Pages: 341-349, ISSN: 1868-596X
Hollnagel HM, Bellion P, Buist H, et al., 2022, Introduction to TTC - concept, databases, excluded substances and sources of uncertainty, 16th International Congress of Toxicology (ICT) - Uniting in Toxicology, Publisher: ELSEVIER IRELAND LTD, Pages: S8-S8, ISSN: 0378-4274
Boobis A, 2022, Synthesis and integration of epidemiological and toxicological evidence, 16th International Congress of Toxicology (ICT) - Uniting in Toxicology, Publisher: ELSEVIER IRELAND LTD, Pages: S47-S47, ISSN: 0378-4274
Doe JE, Boobis AR, Cohen SM, et al., 2022, A new approach to the classification of carcinogenicity, ARCHIVES OF TOXICOLOGY, Vol: 96, Pages: 2419-2428, ISSN: 0340-5761
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- Citations: 3
Knowles ME, Anelich LE, Boobis AR, et al., 2022, Preface, Present Knowledge in Food Safety: A Risk-Based Approach through the Food Chain, Pages: xxxi-xxxi
Knowles ME, Anelich LE, Boobis AR, et al., 2022, Present Knowledge in Food Safety: A Risk-Based Approach Through the Food Chain, ISBN: 9780128231548
Present Knowledge in Food Safety: A Risk-Based Approach Through the Food Chain presents approaches for exposure-led risk assessment and the management of changes in the chemical, pathogenic microbiological and physical (radioactivity) contamination of ’food’ at all key stages of production, from farm to consumption. This single volume resource introduces scientific advances at all stages of the production to improve reliability, predictability and relevance of food safety assessments for the protection of public health. This book is aimed at a diverse audience, including graduate and post-graduate students in food science, toxicology, microbiology, medicine, public health, and related fields. The book's reach also includes government agencies, industrial scientists, and policymakers involved in food risk analysis.
Tan Y-M, Barton HA, Boobis A, et al., 2021, Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment, REGULATORY TOXICOLOGY AND PHARMACOLOGY, Vol: 127, ISSN: 0273-2300
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- Citations: 9
Doe JE, Boobis AR, Cohen SM, et al., 2021, The codification of hazard and its impact on the hazard versus risk controversy, ARCHIVES OF TOXICOLOGY, Vol: 95, Pages: 3611-3621, ISSN: 0340-5761
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- Citations: 4
Barile FA, Berry C, Blaauboer B, et al., 2021, The EU chemicals strategy for sustainability: in support of the BfR position, ARCHIVES OF TOXICOLOGY, Vol: 95, Pages: 3133-3136, ISSN: 0340-5761
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- Citations: 7
Doerr B, Boobis A, 2021, The UK Committee on Toxicity (COT) and on Carcinogenicity (COC) of Chemicals in Food, Consumer Products and the Environment: Guidance for synthesising and integration of epidemiological and toxicological evidence, 56th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology of the Next Generation, Publisher: ELSEVIER IRELAND LTD, Pages: S220-S220, ISSN: 0378-4274
Boobis AR, Pettit SD, 2021, Individualized toxicity is the future of risk assessment, 56th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology of the Next Generation, Publisher: ELSEVIER IRELAND LTD, Pages: S11-S11, ISSN: 0378-4274
Boobis AR, 2021, Current challenges in a paradigm shift for cancer risk assessment, 56th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology of the Next Generation, Publisher: ELSEVIER IRELAND LTD, Pages: S40-S40, ISSN: 0378-4274
Nyakutsikwa B, Britton J, Bogdanovica I, et al., 2021, Characterising vaping products in the United Kingdom: an analysis of Tobacco Products Directive notification data, ADDICTION, Vol: 116, Pages: 2521-2528, ISSN: 0965-2140
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- Citations: 4
Barile FA, Berry SC, Blaauboer B, et al., 2021, Critique of the "Comment" etitled "Pyrethroid exposure: not so harmless after all" by Demeneix et al. (2020) published in the lancet diabetes endocrinology" (vol 340, pg 1, 2021), TOXICOLOGY LETTERS, Vol: 346, Pages: 57-57, ISSN: 0378-4274
Barile FA, Berry SC, Blaauboer B, et al., 2021, Critique of the "Comment" etitled "<i>Pyrethroid exposure</i>: Not so harmless after all" by Demeneix et al. (2020) published in the lancet diabetes endocrinology, TOXICOLOGY LETTERS, Vol: 340, Pages: 1-3, ISSN: 0378-4274
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- Citations: 1
Fenton SE, Ducatman A, Boobis A, et al., 2021, Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research, ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, Vol: 40, Pages: 606-630, ISSN: 0730-7268
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- Citations: 450
Firman JW, Punt A, Cronin MTD, et al., 2021, Exploring the Potential of ToxCast Data in Supporting Read-Across for Evaluation of Food Chemical Safety, CHEMICAL RESEARCH IN TOXICOLOGY, Vol: 34, Pages: 300-312, ISSN: 0893-228X
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- Citations: 7
Autrup H, Barile FA, Berry SC, et al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, TOXICOLOGY LETTERS, Vol: 331, Pages: 259-264, ISSN: 0378-4274
Sewell F, Kimber I, Boobis AR, 2020, Use of the kinetically-derived maximum dose: Opportunities for delivering 3Rs benefits, REGULATORY TOXICOLOGY AND PHARMACOLOGY, Vol: 116, ISSN: 0273-2300
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- Citations: 7
Whaley P, Aiassa E, Beausoleil C, et al., 2020, Recommendations for the conduct of systematic reviews in toxicology and environmental health research (COSTER), ENVIRONMENT INTERNATIONAL, Vol: 143, ISSN: 0160-4120
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- Citations: 44
Kumar V, Boobis AR, Moretto A, 2020, Test and Risk Assessment Strategies for combined exposure to multiple chemicals, FOOD AND CHEMICAL TOXICOLOGY, Vol: 144, ISSN: 0278-6915
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- Citations: 7
Autrup H, Barile FA, Berry SC, et al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, TOXICOLOGY IN VITRO, Vol: 67, ISSN: 0887-2333
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- Citations: 3
Autrup H, Barile FA, Berry SC, et al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, CHEMICO-BIOLOGICAL INTERACTIONS, Vol: 326, ISSN: 0009-2797
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- Citations: 2
Autrup H, Barile FA, Berry SC, et al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, FOOD AND CHEMICAL TOXICOLOGY, Vol: 142, ISSN: 0278-6915
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- Citations: 1
Autrup H, Barile FA, Berry SC, et al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, Vol: 78, ISSN: 1382-6689
Autrup H, Barile FA, Berry SC, et al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, Vol: 83, Pages: 485-494, ISSN: 1528-7394
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- Citations: 6
Mahony C, Ashton RS, Birk B, et al., 2020, New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop, REGULATORY TOXICOLOGY AND PHARMACOLOGY, Vol: 114, ISSN: 0273-2300
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- Citations: 24
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