Imperial College London

ProfessorAnneBowcock

Faculty of MedicineNational Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 1511a.bowcock

 
 
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Location

 

Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bowcock:1993,
author = {Bowcock, AM and Anderson, LA and Friedman, LS and Black, DM and Osborne-Lawrence, S and Rowell, SE and Hall, JM and Solomon, E and King, MC},
journal = {Am J Hum Genet},
pages = {718--722},
title = {THRA1 and D17S183 flank an interval of < 4 cM for the breast-ovarian cancer gene (BRCA1) on chromosome 17q21.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/8460637},
volume = {52},
year = {1993}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - In order to pinpoint the locale of the gene for early-onset familial breast and ovarian cancer (BRCA1), polymorphisms were developed within the locus for thyroid hormone receptor alpha (THRA1) and for several anonymous sequences at chromosome 17q12-q21. The THRA1 polymorphism is a dinucleotide repeat with 10 alleles and heterozygosity.79. Gene mapping in extended families with inherited, early-onset breast and ovarian cancer indicates that BRCA1 is distal to THRA1 and proximal to D17S183 (SCG43), an interval of < 4 cM. This locale excludes HER2, THRA1, WNT3, HOX2, NGFR, PHB, COLIA1, NME1, and NME2 as candidates for BRCA1 but does not exclude RARA or EDH17B. Resolving the remaining recombination events in these families by new polymorphisms in the THRA1-D17S183 interval will facilitate positional cloning of the breast-ovarian cancer gene on chromosome 17q12-q21.
AU - Bowcock,AM
AU - Anderson,LA
AU - Friedman,LS
AU - Black,DM
AU - Osborne-Lawrence,S
AU - Rowell,SE
AU - Hall,JM
AU - Solomon,E
AU - King,MC
EP - 722
PY - 1993///
SN - 0002-9297
SP - 718
TI - THRA1 and D17S183 flank an interval of < 4 cM for the breast-ovarian cancer gene (BRCA1) on chromosome 17q21.
T2 - Am J Hum Genet
UR - https://www.ncbi.nlm.nih.gov/pubmed/8460637
VL - 52
ER -