Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Visiting Professor



+44 (0)20 7594 1511a.bowcock




Guy Scadding BuildingRoyal Brompton Campus






BibTex format

author = {Mountain, JL and Lin, AA and Bowcock, AM and Cavalli-Sforza, LL},
doi = {10.1098/rstb.1992.0093},
journal = {Philos Trans R Soc Lond B Biol Sci},
pages = {159--165},
title = {Evolution of modern humans: evidence from nuclear DNA polymorphisms.},
url = {},
volume = {337},
year = {1992}

RIS format (EndNote, RefMan)

AB - Previously we have described studies of the evolution of modern humans based upon data for classical genetic markers and for nuclear DNA polymorphisms. Such polymorphisms provide a different point of view regarding human evolution than do mitochondrial DNA sequences. Here we compare revised dates for major migrations of anatomically modern humans, estimated from archaeological data, with separations suggested by a genetic tree constructed from classical marker allele frequencies. Analyses of DNA polymorphisms have now been extended and compared with those of classical markers; genetic trees continue to support the hypothesis of an initial African and non-African divergence for modern humans. We have also begun testing non-human primates for a set of human DNA polymorphisms. For most polymorphisms tested so far, humans share a single allele with other primates; such shared alleles are likely to be ancestral. Populations living in humid tropical environments have significantly higher frequencies of ancestral alleles than do other populations, supporting the hypothesis that natural selection acts to maintain high frequencies of particular alleles in some environments.
AU - Mountain,JL
AU - Lin,AA
AU - Bowcock,AM
AU - Cavalli-Sforza,LL
DO - 10.1098/rstb.1992.0093
EP - 165
PY - 1992///
SN - 0962-8436
SP - 159
TI - Evolution of modern humans: evidence from nuclear DNA polymorphisms.
T2 - Philos Trans R Soc Lond B Biol Sci
UR -
UR -
VL - 337
ER -