Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Visiting Professor



+44 (0)20 7594 1511a.bowcock




Guy Scadding BuildingRoyal Brompton Campus






BibTex format

author = {Waber, PG and Bowcock, AM and Arencibia-Mireles, O and Nisen, PD},
doi = {jnci/83.15.1085},
journal = {J Natl Cancer Inst},
pages = {1085--1088},
title = {Nonrandom distribution of N-myc oncogene genotypes in neuroblastoma.},
url = {},
volume = {83},
year = {1991}

RIS format (EndNote, RefMan)

AB - The distributions of Pvu II and Sph I alleles of the N-myc oncogene (also known as MYCN) were studied in a series of normal individuals and pediatric patients with solid tumors. In the case of Pvu II, where the polymorphic site is located 3' of the gene, the frequencies of the allele were 0.27 (11-kilobase fragment) and 0.73 (8-kilobase fragment) in 43 unrelated normal Caucasians. The frequencies of the allele were similar in 40 non-N-myc-amplified neuroblastomas, 47 Wilms' tumors, and 31 other pediatric tumors. In these cases, the genotypes were in Hardy-Weinberg equilibrium. In 18 N-myc-amplified neuroblastomas, however, the observed genotype frequencies deviated from Hardy-Weinberg equilibrium (P less than .005). Similar observations were made with an Sph I restriction fragment length polymorphism where the polymorphic site is located in intron 2. The differences between amplified and nonamplified neuroblastomas suggest a possible involvement of sequences at or near N-myc in the progression of tumors where the N-myc gene is amplified.
AU - Waber,PG
AU - Bowcock,AM
AU - Arencibia-Mireles,O
AU - Nisen,PD
DO - jnci/83.15.1085
EP - 1088
PY - 1991///
SN - 0027-8874
SP - 1085
TI - Nonrandom distribution of N-myc oncogene genotypes in neuroblastoma.
T2 - J Natl Cancer Inst
UR -
UR -
VL - 83
ER -