Imperial College London

ProfessorAnneBowcock

Faculty of MedicineNational Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 1511a.bowcock

 
 
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Location

 

Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hsieh:1990,
author = {Hsieh, CL and Bowcock, AM and Farrer, LA and Hebert, JM and Huang, KN and Cavalli-Sforza, LL and Julius, D and Francke, U},
journal = {Somat Cell Mol Genet},
pages = {567--574},
title = {The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/1980030},
volume = {16},
year = {1990}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Serotonin (5-hydroxytryptamine) functions as a neurotransmitter and a hormone. Its diverse actions are mediated by at least seven distinct cell surface receptor subtypes. The serotonin receptor subtype 2 (gene symbol HTR2) is a G-protein-coupled receptor, expressed primarily in the cerebral cortex, where upon stimulation it stimulates the hydrolysis of inositol phospholipids. We have mapped the HTR2 locus to human chromosome 13 and to mouse chromosome 14 by somatic cell hybrid analysis. Linkage studies in CEPH families, using a PvuII RFLP detected with the HTR2 probe, revealed tight linkage between HTR2 and ESD, the locus for esterase D. The most likely position for HTR2 is between ESD and RB1, the retinoblastoma-1 gene. The homologous loci in mouse, Rb-1 and Esd(Es-10) are on mouse chromosome 14, close to ag, agitans, a recessive neurological mutation. Having mapped Htr-2 to mouse chromosome 14, we predict that it falls into this known conserved gene cluster.
AU - Hsieh,CL
AU - Bowcock,AM
AU - Farrer,LA
AU - Hebert,JM
AU - Huang,KN
AU - Cavalli-Sforza,LL
AU - Julius,D
AU - Francke,U
EP - 574
PY - 1990///
SN - 0740-7750
SP - 567
TI - The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14.
T2 - Somat Cell Mol Genet
UR - https://www.ncbi.nlm.nih.gov/pubmed/1980030
VL - 16
ER -