Imperial College London

ProfessorAnneBowcock

Faculty of MedicineNational Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 1511a.bowcock

 
 
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Location

 

Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bowcock:1990,
author = {Bowcock, A and Sartorelli, V},
journal = {Hum Genet},
pages = {349--354},
title = {Polymorphism and mapping of the IGF1 gene, and absence of association with stature among African Pygmies.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/2394448},
volume = {85},
year = {1990}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Probes detecting restriction fragment length polymorphisms (RFLPs) in the insulinlike growth factor (IGF1) gene were isolated and allele frequencies in different human populations determined. No difference was detected between the distribution of IGF1 alleles in Pygmies versus non-Pygmy black Africans, despite the proposal that a defect in the IGF1 gene might be responsible for Pygmy short stature. This was supported by the absence of a correlation of IGF1 genotype with height in the C.A.R. Pygmies. Polymerase chain reaction (PCR) and direct sequencing failed to demonstrate an alteration in the region upstream the IGF1 start site in Pygmies. Linkage analysis demonstrated that IGF1 is tightly linked to the phenylalanine hydroxylase gene on chromosome 12q22-24.1.
AU - Bowcock,A
AU - Sartorelli,V
EP - 354
PY - 1990///
SN - 0340-6717
SP - 349
TI - Polymorphism and mapping of the IGF1 gene, and absence of association with stature among African Pygmies.
T2 - Hum Genet
UR - https://www.ncbi.nlm.nih.gov/pubmed/2394448
VL - 85
ER -