Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Visiting Professor



+44 (0)20 7594 1511a.bowcock




Guy Scadding BuildingRoyal Brompton Campus






BibTex format

author = {Stewart, EA and Craik, CS and Hake, L and Bowcock, AM},
journal = {Am J Hum Genet},
pages = {795--800},
title = {Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31-qter.},
url = {},
volume = {46},
year = {1990}

RIS format (EndNote, RefMan)

AB - A genomic clone for human carboxypeptidase has been isolated with a probe for rat CPA1 cDNA. A 1.7-kb HindIII/EcoRI fragment from the 3' flanking region of human carboxypeptidase detects a DNA polymorphism with BglIII. Multipoint linkage analysis with an established map of chromosome 7 markers shows that the most likely location of carboxypeptidase is at 7q31-qter, between D7S87 and D7S93. All other placements can be excluded with odds greater than 100:1. These and other markers confirm that carboxypeptidase lies distal to the locus for cystic fibrosis, at a distance of approximately 12 centimorgans. The regions containing identity to the rat gene were sequenced and shown to be 82% identical to exons 9 and 10 of the rat gene. The presence of a codon for isoleucine at the residues corresponding to codon 255 of rat CPA1 cDNA strongly suggests that the A form of human carboxypeptidase has been isolated.
AU - Stewart,EA
AU - Craik,CS
AU - Hake,L
AU - Bowcock,AM
EP - 800
PY - 1990///
SN - 0002-9297
SP - 795
TI - Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31-qter.
T2 - Am J Hum Genet
UR -
VL - 46
ER -