Imperial College London

ProfessorAnneBowcock

Faculty of MedicineNational Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 1511a.bowcock

 
 
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Location

 

Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bowcock:1990,
author = {Bowcock, AM and Hall, JM and Hebert, JM and King, MC},
journal = {Am J Hum Genet},
pages = {12--17},
title = {Exclusion of the retinoblastoma gene and chromosome 13q as the site of a primary lesion for human breast cancer.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/2294744},
volume = {46},
year = {1990}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Chromosome 13q has been suggested as the site of a gene predisposing to human breast cancer, because loss of heterozygosity of alleles on this chromosome has been observed in some ductal breast tumors and because two breast cancer lines are altered at the retinoblastoma gene (RB1) at 13q14. To test this possibility, linkage of breast cancer susceptibility to 14 loci on chromosome 13q loci was assessed in extended families in which breast cancer is apparently inherited as an autosomal dominant trait. RB1 was excluded as the site of a breast cancer gene by a lod score of Z = -7.60 at close linkage for 13 families. Multipoint analysis yielded negative lod scores throughout the region between 13q12 and 13q34; over most of this distance, Z less than -2.0. Therefore, chromosome 13q appears to be excluded as the site of primary lesion for breast cancer in these families. In addition, comparison of tumor versus normal tissues of nonfamilial breast cancer patients revealed an alteration at the 5' end of RB1 in a mucoid carcinoma but no alterations of RB1 in five informative ductal adenocarcinomas. Linkage data and comparisons of tumor and normal tissues suggest that changes in the RBI locus either are secondary alterations associated with progression of some tumors or occur by chance.
AU - Bowcock,AM
AU - Hall,JM
AU - Hebert,JM
AU - King,MC
EP - 17
PY - 1990///
SN - 0002-9297
SP - 12
TI - Exclusion of the retinoblastoma gene and chromosome 13q as the site of a primary lesion for human breast cancer.
T2 - Am J Hum Genet
UR - https://www.ncbi.nlm.nih.gov/pubmed/2294744
VL - 46
ER -