Imperial College London

ProfessorAnneBowcock

Faculty of MedicineNational Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 1511a.bowcock

 
 
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Location

 

Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bowcock:1988:10.1073/pnas.85.8.2701,
author = {Bowcock, AM and Hebert, JM and Wijsman, E and Gadi, I and Cavalli-Sforza, LL and Boyd, CD},
doi = {10.1073/pnas.85.8.2701},
journal = {Proc Natl Acad Sci U S A},
pages = {2701--2705},
title = {High recombination between two physically close human basement membrane collagen genes at the distal end of chromosome 13q.},
url = {http://dx.doi.org/10.1073/pnas.85.8.2701},
volume = {85},
year = {1988}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Two basement membrane collagen genes coding for the pro alpha 1 chain and pro alpha 2 chain of type IV collagen map to 13q34 and are linked with a maximum likelihood estimate of recombination of 0.028 at a logarithm of odds (lod) score of 19.98. The single-copy sequence that identifies the locus D13S3 is also closely linked to both collagen genes. Four enzymes reveal polymorphisms with COL4A1, and 10 haplotypes have been observed in Caucasoids. Within COL4A1 a nonrandom association of alleles exists only between alleles defined by Hae III and those defined by the other three enzymes. A random association of alleles of COL4A1 and COL4A2 is observed. Between the two collagen genes were detected three meiotic recombination events that contributed to the estimate of 2.8% recombination. This is higher than expected for two genes that lie within 650 kilobases of each other. The lack of linkage disequilibrium between COL4A1 and COL4A2 is in agreement with the relatively high recombination that is observed.
AU - Bowcock,AM
AU - Hebert,JM
AU - Wijsman,E
AU - Gadi,I
AU - Cavalli-Sforza,LL
AU - Boyd,CD
DO - 10.1073/pnas.85.8.2701
EP - 2705
PY - 1988///
SN - 0027-8424
SP - 2701
TI - High recombination between two physically close human basement membrane collagen genes at the distal end of chromosome 13q.
T2 - Proc Natl Acad Sci U S A
UR - http://dx.doi.org/10.1073/pnas.85.8.2701
UR - https://www.ncbi.nlm.nih.gov/pubmed/2895928
VL - 85
ER -