264 results found
Roberts RE, Ahmad H, Patel M, et al., 2018, An fMRI study of visuo-vestibular interactions following vestibular neuritis., Neuroimage Clin, Vol: 20, Pages: 1010-1017
Vestibular neuritis (VN) is characterised by acute vertigo due to a sudden loss of unilateral vestibular function. A considerable proportion of VN patients proceed to develop chronic symptoms of dizziness, including visually induced dizziness, specifically during head turns. Here we investigated whether the development of such poor clinical outcomes following VN, is associated with abnormal visuo-vestibular cortical processing. Accordingly, we applied functional magnetic resonance imaging to assess brain responses of chronic VN patients and compared these to controls during both congruent (co-directional) and incongruent (opposite directions) visuo-vestibular stimulation (i.e. emulating situations that provoke symptoms in patients). We observed a focal significant difference in BOLD signal in the primary visual cortex V1 between patients and controls in the congruent condition (small volume corrected level of p < .05 FWE). Importantly, this reduced BOLD signal in V1 was negatively correlated with functional status measured with validated clinical questionnaires. Our findings suggest that central compensation and in turn clinical outcomes in VN are partly mediated by adaptive mechanisms associated with the early visual cortex.
Ahmad H, Roberts RE, Patel M, et al., 2017, Downregulation of early visual cortex excitability mediates oscillopsia suppression, NEUROLOGY, Vol: 89, Pages: 1179-1185, ISSN: 0028-3878
Kaski D, Bronstein AM, 2017, Ocular Tremor in Parkinson's Disease: Discussion, Debate, and Controversy, FRONTIERS IN NEUROLOGY, Vol: 8, ISSN: 1664-2295
Lubeck AJA, Van Ombergen A, Ahmad H, et al., 2017, Differential effect of visual motion adaption upon visual cortical excitability, JOURNAL OF NEUROPHYSIOLOGY, Vol: 117, Pages: 903-909, ISSN: 0022-3077
Panichi R, Faralli M, Bruni R, et al., 2017, Asymmetric vestibular stimulation reveals persistent disruption of motion perception in unilateral vestibular lesions, JOURNAL OF NEUROPHYSIOLOGY, Vol: 118, Pages: 2819-2832, ISSN: 0022-3077
Roberts RE, Ahmad H, Arshad Q, et al., 2017, Functional neuroimaging of visuo-vestibular interaction, BRAIN STRUCTURE & FUNCTION, Vol: 222, Pages: 2329-2343, ISSN: 1863-2653
Arshad Q, Nigmatullina Y, Roberts RE, et al., 2016, Perceived state of self during motion can differentially modulate numerical magnitude allocation, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 44, Pages: 2369-2374, ISSN: 0953-816X
Bronstein AM, 2016, Multisensory integration in balance control., Handb Clin Neurol, Vol: 137, Pages: 57-66, ISSN: 0072-9752
This chapter provides an introduction to the topic of multisensory integration in balance control in, both, health and disease. One of the best-studied examples is that of visuo-vestibular interaction, which is the ability of the visual system to enhance or suppress the vestibulo-ocular reflex (VOR suppression). Of clinical relevance, examination of VOR suppression is clinically useful because only central, not peripheral, lesions impair VOR suppression. Visual, somatosensory (proprioceptive), and vestibular inputs interact strongly and continuously in the control of upright balance. Experiments with visual motion stimuli show that the visual system generates visually-evoked postural responses that, at least initially, can override vestibular and proprioceptive signals. This paradigm has been useful for the study of the syndrome of visual vertigo or vision-induced dizziness, which can appear after vestibular disease. These patients typically report dizziness when exposed to optokinetic stimuli or visually charged environments, such as supermarkets. The principles of the rehabilitation treatment of these patients, which use repeated exposure to visual motion, are presented. Finally, we offer a diagnostic algorithm in approaching the patient reporting oscillopsia - the illusion of oscillation of the visual environment, which should not be confused with the syndrome mentioned earlier of visual vertigo.
Kaski D, Bronstein AM, 2016, PATIENTS WITH VESTIBULAR LOSS, TULLIO PHENOMENON, AND PRESSURE-INDUCED NYSTAGMUS: VESTIBULAR ATELECTASIS?, OTOLOGY & NEUROTOLOGY, Vol: 37, Pages: 115-116, ISSN: 1531-7129
Kaski D, Bronstein AM, 2016, Functional (psychogenic) saccadic oscillations and oculogyric crises Reply, LANCET NEUROLOGY, Vol: 15, Pages: 791-792, ISSN: 1474-4422
Kaski D, Bronstein AM, 2016, Functional eye movement disorders., Handb Clin Neurol, Vol: 139, Pages: 343-351, ISSN: 0072-9752
Functional (psychogenic) eye movement disorders are perhaps less established in the medical literature than other types of functional movement disorders. Patients may present with ocular symptoms (e.g., blurred vision or oscillopsia) or functional eye movements may be identified during the formal examination of the eyes in patients with other functional disorders. Convergence spasm is the most common functional eye movement disorder, but functional gaze limitation, functional eye oscillations (also termed "voluntary nystagmus"), and functional convergence paralysis may be underreported. This chapter reviews the different types of functional eye movement abnormalities and provides a practical framework for their diagnosis and management.
Kaski D, Pradhan V, Bronstein A, 2016, THE CLINICAL FEATURES OF FUNCTIONAL (PSYCHOGENIC) EYE MOVEMENTS, Annual Meeting of the Association-of-British-Neurologists (ABN), Publisher: BMJ PUBLISHING GROUP, ISSN: 0022-3050
Kaski D, Pradhan V, Bronstein AM, 2016, Clinical features of functional (psychogenic) eye movement disorders, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 87, Pages: 1389-+, ISSN: 0022-3050
Kaski D, Quadir S, Nigmatullina Y, et al., 2016, Temporoparietal encoding of space and time during vestibular-guided orientation, BRAIN, Vol: 139, Pages: 392-403, ISSN: 0006-8950
Nigmatullina Y, Siddiqui S, Khan S, et al., 2016, Lateralisation of the Vestibular Cortex Is More Pronounced in Left-Handers, BRAIN STIMULATION, Vol: 9, Pages: 942-944, ISSN: 1935-861X
Patel M, Agarwal K, Arshad Q, et al., 2016, Intratympanic methylprednisolone versus gentamicin in patients with unilateral Meniere's disease: a randomised, double-blind, comparative effectiveness trial, LANCET, Vol: 388, Pages: 2753-2762, ISSN: 0140-6736
Patel M, Arshad Q, Roberts RE, et al., 2016, Chronic Symptoms After Vestibular Neuritis and the High-Velocity Vestibulo-Ocular Reflex, OTOLOGY & NEUROTOLOGY, Vol: 37, Pages: 179-184, ISSN: 1531-7129
Ahmad H, Arshad Q, Patel M, et al., 2015, ACQUIRED PENDULAR NYSTAGMUS IN STARGARDT'S SYNDROME SUPPRESSED BY ALCOHOL, Annual Meeting of the Association-of-British-Neurologists (ABN), Publisher: BMJ PUBLISHING GROUP, ISSN: 0022-3050
Ahmad H, Cerchiai N, Mancuso M, et al., 2015, ARE WHITE MATTER ABNORMALITIES A CAUSE OF 'UNEXPLAINED DIZZINESS'? A RETROSPECTIVE BICENTRE STUDY, Annual Meeting of the Association-of-British-Neurologists (ABN), Publisher: BMJ PUBLISHING GROUP, ISSN: 0022-3050
Ahmad H, Cerchiai N, Mancuso M, et al., 2015, White matter abnormalities in dizzy patients: retrospective cohort multi - centre study, 1st Congress of the European-Academy-of-Neurology, Publisher: WILEY, Pages: 365-365, ISSN: 1351-5101
Ahmad H, Cerchiai N, Mancuso M, et al., 2015, Are white matter abnormalities associated with "unexplained dizziness"?, JOURNAL OF THE NEUROLOGICAL SCIENCES, Vol: 358, Pages: 428-431, ISSN: 0022-510X
Ahmad H, Cerchiai N, Mancuso M, et al., 2015, Are white matter abnormalities a cause of "unexplained dizziness"?: A retrospective bi-centre study, 22nd World Congress of Neurology (WCN), Publisher: ELSEVIER SCIENCE BV, Pages: E45-E45, ISSN: 0022-510X
Ahmad H, Roberts R, Arshad QA, et al., 2015, USING TRANSCRANIAL MAGNETIC STIMULATION (TMS) TO PROBE EFFECTS OF VISUAL MOTION ADAPTATION ON PRIMARY VISUAL CORTEX (V1) EXCITABILITY IN BILATERAL VESTIBULAR FAILURE (BVF) PATIENTS, Annual Meeting of the Association-of-British-Neurologists (ABN), Publisher: BMJ PUBLISHING GROUP, ISSN: 0022-3050
Ahmad H, Roberts R, Patel M, et al., 2015, Using transcranial magnetic stimulation (TMS) to probe effects of visual motion adaptation on primary visual cortex (V1) excitability in bilateral vestibular failure patients, 1st Congress of the European-Academy-of-Neurology, Publisher: WILEY, Pages: 51-51, ISSN: 1351-5101
Ahmad H, Roberts RE, Arshad Q, et al., 2015, Probing effects of visual motion adaptation on primary visual cortex (V1) excitability using Tms in Bilateral Vestibular Failure (Bvf) patients, JOURNAL OF THE NEUROLOGICAL SCIENCES, Vol: 357, Pages: E172-E172, ISSN: 0022-510X
Anastasopoulos D, Naushahi J, Sklavos S, et al., 2015, Fast gaze reorientations by combined movements of the eye, head, trunk and lower extremities, EXPERIMENTAL BRAIN RESEARCH, Vol: 233, Pages: 1639-1650, ISSN: 0014-4819
Arshad Q, Patel M, Goga U, et al., 2015, Role of handedness-related vestibular cortical dominance upon the vestibular-ocular reflex, JOURNAL OF NEUROLOGY, Vol: 262, Pages: 1069-1071, ISSN: 0340-5354
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