Imperial College London

ProfessorAdolfoBronstein

Faculty of MedicineDepartment of Medicine

Clinical Professor Head of Neuro-otology Unit
 
 
 
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Contact

 

+44 (0)20 3313 5525a.bronstein

 
 
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Assistant

 

Miss Lorna Stevenson +44 (0)20 3313 5525

 
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Location

 

10 L15bLab BlockCharing Cross Campus

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Summary

 

Publications

Publication Type
Year
to

391 results found

Bronstein AM, Dieterich M, 2019, Long-term clinical outcome in vestibular neuritis., Curr Opin Neurol, Vol: 32, Pages: 174-180

PURPOSE OF REVIEW: To review recent work on clinical and imaging aspects of vestibular neuritis (or acute vestibular syndrome), in particular with a view to identifying factors predicting long-term clinical outcome. RECENT FINDINGS: Evidence for a role of inflammation in the vestibular nerve, and the presence of Gadolinium enhancement acutely in vestibular neuritis, is accruing. Visual dependence, anxiety and somatization traits predict the development of chronic dizziness after acute vestibular neuritis. Adaptation to asymmetric rotation is impaired in vestibular neuritis and this may indicate insufficient central compensation in chronic dizzy patients. Corticosteroids appear ineffective at improving long-term clinical outcome. Functional imaging changes during the central compensation period lead to structural brain changes; both processes correlate with clinical recovery. SUMMARY: Vestibular neuritis appears to be the result of postviral neuroinflammation of the vestibular nerve. However, long-term prognosis is not dependent on the magnitude of the peripheral residual damage (as measured with caloric and video head-impulse test). Instead, a combination of visuovestibular psychophysical factors (visual dependence), psychological traits and dysfunctional vestibular perception are relevant. Several functional and structural neuroimaging changes develop after vestibular neuritis, which reflect and underlie the aforementioned psychophysiological and psychological features.

JOURNAL ARTICLE

Edwards AE, Guven O, Furman MD, Arshad Q, Bronstein AMet al., 2018, Electroencephalographic Correlates of Continuous Postural Tasks of Increasing Difficulty, NEUROSCIENCE, Vol: 395, Pages: 35-48, ISSN: 0306-4522

JOURNAL ARTICLE

Balint B, Antelmi E, Mencacci NE, Batla A, Eriksson SH, Walker MC, Bronstein AM, Bhatia KPet al., 2018, Oculomotor apraxia and disrupted sleep with nocturnal ballistic bouts in ADCY5-related disease, PARKINSONISM & RELATED DISORDERS, Vol: 54, Pages: 103-106, ISSN: 1353-8020

JOURNAL ARTICLE

Kaski D, Haider S, Male A, Radunovich A, Liu F, Cordivari C, Bhatia KP, Bronstein AMet al., 2018, Adult Periodic Alternating Nystagmus Masked by Involuntary Head Movements, FRONTIERS IN NEUROLOGY, Vol: 9, ISSN: 1664-2295

JOURNAL ARTICLE

Ortega MC, Bednarczuk NF, Fluri A-S, Chan J, Rust H, de Melo F, Kaski D, Seemungal BM, Bronstein AM, Arshad Qet al., 2018, Abnormal Visuo-vestibular Interactions in Vestibular Migraine, 70th Annual Meeting of the American-Academy-of-Neurology (AAN), Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0028-3878

CONFERENCE PAPER

Ahmad H, Requena T, Frejo L, Cobo M, Gallego-Martinez A, Martin F, Lopez-Escamez JA, Bronstein AMet al., 2018, Clinical and Functional Characterization of a Missense ELF2 Variant in a CANVAS Family, FRONTIERS IN GENETICS, Vol: 9, ISSN: 1664-8021

JOURNAL ARTICLE

Roberts RE, Ahmad H, Patel M, Dima D, Ibitoye R, Sharif M, Leech R, Arshad Q, Bronstein AMet al., 2018, An fMRI study of visuo-vestibular interactions following vestibular neuritis, NEUROIMAGE-CLINICAL, Vol: 20, Pages: 1010-1017, ISSN: 2213-1582

JOURNAL ARTICLE

Castro P, Sena Esteves S, Lerchundi F, Buckwell D, Gresty MA, Bronstein AM, Arshad Qet al., 2018, Viewing Target Distance Influences the Vestibulo-Ocular Reflex Gain when Assessed Using the Video Head Impulse Test., Audiol Neurootol, Vol: 23, Pages: 285-289

Gaze stabilization during head movements is provided by the vestibulo-ocular reflex (VOR). Clinical assessment of this reflex is performed using the video Head Impulse Test (vHIT). To date, the influence of different fixation distances on VOR gain using the vHIT has not been explored. We assessed the effect of target proximity on the horizontal VOR using the vHIT. Firstly, we assessed the VOR gain in 18 healthy subjects with 5 viewing target distances (150, 40, 30, 20, and 10 cm). The gain increased significantly as the viewing target distance decreased. A second experiment on 10 subjects was performed in darkness whilst the subjects were imagining targets at different distances. There were significant inverse relationships between gain and distance for both the real and the imaginary targets. There was a statistically significant difference between light and dark gains for the 20- and 40-cm distances, but not for the 150-cm distance. Theoretical VOR gains for different target distances were calculated and compared with those found in light and darkness. The increase in gain observed for near targets was lower than predicted by geometrical calculations, implying a physiological ceiling effect on the VOR. The VOR gain in the dark, as assessed with the vHIT, demonstrates an enhancement associated with a reduced target distance.

JOURNAL ARTICLE

Arshad Q, Nigmatullina Y, Siddiqui S, Franka M, Mediratta S, Ramachandaran S, Lobo R, Malhotra PA, Roberts RE, Bronstein AMet al., 2017, Influence of biases in numerical magnitude allocation on human prosocial decision making, JOURNAL OF NEUROPHYSIOLOGY, Vol: 118, Pages: 3007-3013, ISSN: 0022-3077

JOURNAL ARTICLE

Panichi R, Faralli M, Bruni R, Kiriakarely A, Occhigrossi C, Ferraresi A, Bronstein AM, Pettorossi VEet al., 2017, Asymmetric vestibular stimulation reveals persistent disruption of motion perception in unilateral vestibular lesions, JOURNAL OF NEUROPHYSIOLOGY, Vol: 118, Pages: 2819-2832, ISSN: 0022-3077

JOURNAL ARTICLE

Bronstein A, 2017, Clinical neuro-otology of spatial orientation, 23rd World Congress of Neurology (WCN), Publisher: ELSEVIER SCIENCE BV, Pages: 15-15, ISSN: 0022-510X

CONFERENCE PAPER

Arshad Q, Bonsu A, Lobo R, Fluri A-S, Sheriff R, Bain P, Pavese N, Bronstein AMet al., 2017, Biased numerical cognition impairs economic decision-making in Parkinson's disease, ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, Vol: 4, Pages: 739-748, ISSN: 2328-9503

JOURNAL ARTICLE

Ahmad H, Roberts RE, Patel M, Lobo R, Seemungal B, Arshad Q, Bronstein Aet al., 2017, Downregulation of early visual cortex excitability mediates oscillopsia suppression, NEUROLOGY, Vol: 89, Pages: 1179-1185, ISSN: 0028-3878

JOURNAL ARTICLE

Bednarczuk NF, Ortega MC, Fluri A-S, Bronstein AM, Arshad Qet al., 2017, Inter-hemispheric control of vestibular thresholds, BRAIN STIMULATION, Vol: 10, Pages: 988-991, ISSN: 1935-861X

JOURNAL ARTICLE

Roberts RE, Ahmad H, Arshad Q, Patel M, Dima D, Leech R, Seemungal BM, Sharp DJ, Bronstein AMet al., 2017, Functional neuroimaging of visuo-vestibular interaction, BRAIN STRUCTURE & FUNCTION, Vol: 222, Pages: 2329-2343, ISSN: 1863-2653

JOURNAL ARTICLE

Geraghty AWA, Essery R, Kirby S, Stuart B, Turner D, Little P, Bronstein A, Andersson G, Carlbring P, Yardley Let al., 2017, Internet-Based Vestibular Rehabilitation for Older Adults With Chronic Dizziness: A Randomized Controlled Trial in Primary Care, ANNALS OF FAMILY MEDICINE, Vol: 15, Pages: 209-216, ISSN: 1544-1709

JOURNAL ARTICLE

Kaski D, Bronstein AM, 2017, Ocular Tremor in Parkinson's Disease: Discussion, Debate, and Controversy, FRONTIERS IN NEUROLOGY, Vol: 8, ISSN: 1664-2295

JOURNAL ARTICLE

Lubeck AJA, Van Ombergen A, Ahmad H, Bos JE, Wuyts FL, Bronstein AM, Arshad Qet al., 2017, Differential effect of visual motion adaption upon visual cortical excitability, JOURNAL OF NEUROPHYSIOLOGY, Vol: 117, Pages: 903-909, ISSN: 0022-3077

JOURNAL ARTICLE

Lyon S, Goodkin DA, Bronstein AM, Tatem AJ, Bown Met al., 2017, Clinical News., Br J Hosp Med (Lond), Vol: 78, Pages: 8-11, ISSN: 1750-8460

JOURNAL ARTICLE

Staab JP, Eckhardt-Henn A, Horii A, Jacob R, Strupp M, Brandt T, Bronstein Aet al., 2017, Diagnostic criteria for persistent postural-perceptual dizziness (PPPD): Consensus document of the committee for the Classification of Vestibular Disorders of the Barany Society, JOURNAL OF VESTIBULAR RESEARCH-EQUILIBRIUM & ORIENTATION, Vol: 27, Pages: 191-208, ISSN: 0957-4271

JOURNAL ARTICLE

Patel M, Agarwal K, Arshad Q, Hariri M, Rea P, Seemungal BM, Golding JF, Harcourt JP, Bronstein AMet al., 2016, Intratympanic methylprednisolone versus gentamicin in patients with unilateral Meniere's disease: a randomised, double-blind, comparative effectiveness trial, LANCET, Vol: 388, Pages: 2753-2762, ISSN: 0140-6736

JOURNAL ARTICLE

Kaski D, Pradhan V, Bronstein AM, 2016, Clinical features of functional (psychogenic) eye movement disorders, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 87, Pages: 1389-+, ISSN: 0022-3050

JOURNAL ARTICLE

Kaski D, Pradhan V, Bronstein A, 2016, THE CLINICAL FEATURES OF FUNCTIONAL (PSYCHOGENIC) EYE MOVEMENTS, Annual Meeting of the Association-of-British-Neurologists (ABN), Publisher: BMJ PUBLISHING GROUP, ISSN: 0022-3050

CONFERENCE PAPER

Kaski D, Pradhan V, Bronstein AM, 2016, Clinical features of functional (psychogenic) eye movement disorders., J Neurol Neurosurg Psychiatry, Vol: 87, Pages: 1389-1392

JOURNAL ARTICLE

Nigmatullina Y, Siddiqui S, Khan S, Sander K, Lobo R, Bronstein AM, Arshad Qet al., 2016, Lateralisation of the Vestibular Cortex Is More Pronounced in Left-Handers, BRAIN STIMULATION, Vol: 9, Pages: 942-944, ISSN: 1935-861X

JOURNAL ARTICLE

Arshad Q, Nigmatullina Y, Roberts RE, Goga U, Pikovsky M, Khan S, Lobo R, Flury A-S, Pettorossi VE, Cohen-Kadosh R, Malhotra PA, Bronstein AMet al., 2016, Perceived state of self during motion can differentially modulate numerical magnitude allocation, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 44, Pages: 2369-2374, ISSN: 0953-816X

JOURNAL ARTICLE

, 2016, Dizziness, Medicine (United Kingdom), Vol: 44, Pages: 484-487, ISSN: 1357-3039

© 2016 Elsevier Ltd Dizziness and vertigo are common symptoms. Because there are effective treatments for vestibular disorders, it is always important to make an accurate diagnosis. In acute vertigo, expert clinical assessment is critically important in discerning stroke from non-stroke causes because stroke-protocol brain magnetic resonance imaging results, including diffusion-weighted imaging, can be falsely negative in the first 24 hours. It follows that acute medical services must have access to clinicians expert in assessing acute vertigo. Expertise in clinical examination and the interpretation of findings requires appropriate training, but in this article we outline the basic diagnostic and therapeutic approach to patients with dizziness.

JOURNAL ARTICLE

Kaski D, Bronstein AM, 2016, Functional (psychogenic) saccadic oscillations and oculogyric crises Reply, LANCET NEUROLOGY, Vol: 15, Pages: 791-792, ISSN: 1474-4422

JOURNAL ARTICLE

Arshad Q, Bonsu A, Malhotra PA, Pavese N, Bronstein Aet al., 2016, Influence of lateralised hemispheric asymmetries upon numerical cognition and its influence upon pro-social decision making in Parkinson's disease, Publisher: WILEY, Pages: 97-97, ISSN: 1351-5101

CONFERENCE PAPER

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