Publications
429 results found
Schneider R, Liao K, Walker MF, et al., 2014, Behavior of the human translational vestibulo-ocular reflex during simultaneous head translation and rotation, JOURNAL OF VESTIBULAR RESEARCH-EQUILIBRIUM & ORIENTATION, Vol: 24, Pages: 329-333, ISSN: 0957-4271
Cutfield NJ, Scott G, Waldman AD, et al., 2014, Visual and proprioceptive interaction in patients with bilateral vestibular loss, NEUROIMAGE-CLINICAL, Vol: 4, Pages: 274-282, ISSN: 2213-1582
Following bilateral vestibular loss (BVL) patients gradually adapt to the loss of vestibular input and rely more on other sensory inputs. Here we examine changes in the way proprioceptive and visual inputs interact. We used functional magnetic resonance imaging (fMRI) to investigate visual responses in the context of varying levels of proprioceptive input in 12 BVL subjects and 15 normal controls. A novel metal-free vibrator was developed to allow vibrotactile neck proprioceptive input to be delivered in the MRI system. A high level (100 Hz) and low level (30 Hz) control stimulus was applied over the left splenius capitis; only the high frequency stimulus generates a significant proprioceptive stimulus. The neck stimulus was applied in combination with static and moving (optokinetic) visual stimuli, in a factorial fMRI experimental design. We found that high level neck proprioceptive input had more cortical effect on brain activity in the BVL patients. This included a reduction in visual motion responses during high levels of proprioceptive input and differential activation in the midline cerebellum. In early visual cortical areas, the effect of high proprioceptive input was present for both visual conditions but in lateral visual areas, including V5/MT, the effect was only seen in the context of visual motion stimulation. The finding of a cortical visuo-proprioceptive interaction in BVL patients is consistent with behavioural data indicating that, in BVL patients, neck afferents partly replace vestibular input during the CNS-mediated compensatory process. An fMRI cervico-visual interaction may thus substitute the known visuo-vestibular interaction reported in normal subject fMRI studies. The results provide evidence for a cortical mechanism of adaptation to vestibular failure, in the form of an enhanced proprioceptive influence on visual processing. The results may provide the basis for a cortical mechanism involved in proprioceptive substitution of vestibular func
Geraghty AWA, Kirby S, Essery R, et al., 2014, Internet-based vestibular rehabilitation for adults aged 50 years and over: a protocol for a randomised controlled trial, BMJ OPEN, Vol: 4, ISSN: 2044-6055
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- Citations: 34
Patel M, Nigmatullina Y, Seemungal BM, et al., 2013, Effects of Prochlorperazine on Normal Vestibular Ocular and Perceptual Responses: A Randomised, Double-Blind, Crossover, Placebo-Controlled Study, Audiology and Neuro-Otology, Vol: 19, Pages: 91-96, ISSN: 1421-9700
Background: The present study investigated whether prochlorperazine affects vestibulo-ocular reflex (VOR) and vestibulo-perceptual function. Methods: We studied 12 healthy naïve subjects 3 h after a single dose of oral prochlorperazine 5 mg in a randomised, placebo-controlled, double-blind, crossover study in healthy young subjects. Two rotational tests in yaw were used: (1) a threshold task investigating perceptual motion detection and nystagmic thresholds (acceleration steps of 0.5°/s2) and (2) suprathreshold responses to velocity steps of 90°/s in which vestibulo-ocular and vestibuloperceptual time constants of decay, as well as VOR gain, were measured. Results: Prochlorperazine had no effect upon any measure of nystagmic or perceptual vestibular function compared to placebo. This lack of effects on vestibular-mediated motion perception suggests that the drug is likely to act more as an anti-emetic than as an antivertiginous agent.
Claassen J, Spiegel R, Kalla R, et al., 2013, A randomised double-blind, cross-over trial of 4-aminopyridine for downbeat nystagmus-effects on slowphase eye velocity, postural stability, locomotion and symptoms, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 84, Pages: 1392-1399, ISSN: 0022-3050
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- Citations: 57
Kaski D, Dominguez R, Allum J, et al., 2013, DIRECT CURRENT STIMULATION AND TRAINING IN PARKINSON'S DISEASE: BETTER OUTCOMES IN MORE ADVANCED DISEASE, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 84, ISSN: 0022-3050
Kaski D, Dominguez R, Allum J, et al., 2013, DIRECT CURRENT STIMULATION AND TRAINING IN PARKINSON'S DISEASE: BETTER OUTCOMES IN MORE ADVANCED DISEASE, Annual Meeting of the Association-of-British-Neurologists, Publisher: BMJ PUBLISHING GROUP, ISSN: 0022-3050
Kaski D, Dominguez RO, Allum JH, et al., 2013, Improving Gait and Balance in Patients With Leukoaraiosis Using Transcranial Direct Current Stimulation and Physical Training: An Exploratory Study, NEUROREHABILITATION AND NEURAL REPAIR, Vol: 27, Pages: 864-871, ISSN: 1545-9683
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- Citations: 43
Papachatzaki MM, Ali N, Arshad Q, et al., 2013, Progressive ataxia with oculo-palatal tremor and optic atrophy, JOURNAL OF NEUROLOGY, Vol: 260, Pages: 2903-2905, ISSN: 0340-5354
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- Citations: 4
Kyriakareli A, Cousins S, Pettorossi VE, et al., 2013, Effect of transcranial direct current stimulation on vestibular-ocular and vestibulo-perceptual thresholds, NEUROREPORT, Vol: 24, Pages: 808-812, ISSN: 0959-4965
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- Citations: 24
Arshad Q, Nigmatullina Y, Bhrugubanda V, et al., 2013, Separate attentional components modulate early visual cortex excitability, CORTEX, Vol: 49, Pages: 2938-2940, ISSN: 0010-9452
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- Citations: 11
Anastasopoulos D, Ziavra N, Pearce R, et al., 2013, Trunk bradykinesia and foveation delays during whole-body turns in spasmodic torticollis, JOURNAL OF NEUROLOGY, Vol: 260, Pages: 2057-2065, ISSN: 0340-5354
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- Citations: 9
Arshad Q, Nigmatullina Y, Roberts RE, et al., 2013, Left Cathodal Trans-Cranial Direct Current Stimulation of the Parietal Cortex Leads to an Asymmetrical Modulation of the Vestibular-Ocular Reflex, BRAIN STIMULATION, Vol: 7, Pages: 85-91, ISSN: 1935-861X
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- Citations: 31
Bronstein AM, Golding JF, Gresty MA, 2013, Vertigo and Dizziness from Environmental Motion: Visual Vertigo, Motion Sickness, and Drivers' Disorientation, SEMINARS IN NEUROLOGY, Vol: 33, Pages: 219-230, ISSN: 0271-8235
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- Citations: 33
Kaski D, Saifee TA, Buckwell D, et al., 2013, Reply to letter-eye oscillations in Parkinson's disease relate to the vestibulo-ocular reflex, MOVEMENT DISORDERS, Vol: 28, Pages: 845-846, ISSN: 0885-3185
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- Citations: 5
Naushahi MJ, Yousif N, Pavese N, et al., 2013, Simultaneous bilateral pedunculopontine nucleus (PPN) and subthalamic nucleus (STN)-deep brain stimulation (DBS) in advanced Parkinson's disease (PD), Publisher: WILEY-BLACKWELL, Pages: S455-S456, ISSN: 0885-3185
Naushahi MJ, Khan AN, Arshad Q, et al., 2013, Different combinations of subthalamic nucleus (STN) and pedunculopontine nucleus (PPN) deep brain stimulation (DBS) lead to variable effects in saccades and antisaccades in advanced Parkinson's disease (PD), Publisher: WILEY-BLACKWELL, Pages: S446-S446, ISSN: 0885-3185
Naushahi MJ, Khan AN, Arshad Q, et al., 2013, Effects of subthalamic nucleus (STN) and pedunculopontine nucleus (PPN)-deep brain stimulation (DBS) on saccades in advanced Parkinson's disease (PD), Publisher: WILEY-BLACKWELL, Pages: S456-S456, ISSN: 0885-3185
Kaski D, Saifee TA, Bronstein AM, 2013, Ocular tremor in Parkinson's disease is due to head oscillation, JOURNAL OF NEUROLOGY, Vol: 260, Pages: S63-S63, ISSN: 0340-5354
Murdin L, Chamberlain F, Cheema S, et al., 2013, The role of motion sickness susceptibility in vestibular disorders and migraine, JOURNAL OF NEUROLOGY, Vol: 260, Pages: S27-S28, ISSN: 0340-5354
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- Citations: 1
Kaski D, Nigmatullina Y, Malhotra P, et al., 2013, A temporoparietal junction timing mechanism mediates human path integration, JOURNAL OF NEUROLOGY, Vol: 260, Pages: S106-S106, ISSN: 0340-5354
Cousins S, Kaski D, Cutfield N, et al., 2013, Vestibular perception following acute unilateral vestibular lesions, JOURNAL OF NEUROLOGY, Vol: 260, Pages: S27-S27, ISSN: 0340-5354
Cousins S, Kaski D, Cutfield N, et al., 2013, Vestibular Perception following Acute Unilateral Vestibular Lesions, PLOS One, Vol: 8, ISSN: 1932-6203
Little is known about the vestibulo-perceptual (VP) system, particularly after a unilateral vestibular lesion. We investigatedvestibulo-ocular (VO) and VP function in 25 patients with vestibular neuritis (VN) acutely (2 days after onset) and aftercompensation (recovery phase, 10 weeks). Since the effect of VN on reflex and perceptual function may differ at thresholdand supra-threshold acceleration levels, we used two stimulus intensities, acceleration steps of 0.5u/s2 and velocity steps of90u/s (acceleration 180u/s2). We hypothesised that the vestibular lesion or the compensatory processes could dissociate VOand VP function, particularly if the acute vertiginous sensation interferes with the perceptual tasks. Both in acute andrecovery phases, VO and VP thresholds increased, particularly during ipsilesional rotations. In signal detection theory thisindicates that signals from the healthy and affected side are still fused, but result in asymmetric thresholds due to a lesioninducedbias. The normal pattern whereby VP thresholds are higher than VO thresholds was preserved, indicating that any‘perceptual noise’ added by the vertigo does not disrupt the cognitive decision-making processes inherent to theperceptual task. Overall, the parallel findings in VO and VP thresholds imply little or no additional cortical processing andsuggest that vestibular thresholds essentially reflect the sensitivity of the fused peripheral receptors. In contrast, asignificant VO-VP dissociation for supra-threshold stimuli was found. Acutely, time constants and duration of the VO and VPresponses were reduced – asymmetrically for VO, as expected, but surprisingly symmetrical for perception. At recovery, VPresponses normalised but VO responses remained shortened and asymmetric. Thus, unlike threshold data, supra-thresholdresponses show considerable VO-VP dissociation indicative of additional, higher-order processing of vestibular signals. Weprovide evidence of perceptual process
Kaski D, Dominguez RO, Bronstein AM, 2013, Motion diplopia in an isolated unilateral internuclear ophthalmoplegia: A new neurological symptom?, CLINICAL NEUROLOGY AND NEUROSURGERY, Vol: 115, Pages: 636-637, ISSN: 0303-8467
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- Citations: 2
Tang K-S, Kaski D, Allum JHJ, et al., 2013, The effect of gait approach velocity on the broken escalator phenomenon, EXPERIMENTAL BRAIN RESEARCH, Vol: 226, Pages: 335-346, ISSN: 0014-4819
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- Citations: 8
Lee P-Y, Gadareh K, Naushahi MJ, et al., 2013, Protective stepping response in Parkinsonian patients and the effect of vibrotactile feedback, MOVEMENT DISORDERS, Vol: 28, Pages: 482-489, ISSN: 0885-3185
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- Citations: 13
Pettorossi VE, Panichi R, Botti FM, et al., 2013, Prolonged asymmetric vestibular stimulation induces opposite, long-term effects on self-motion perception and ocular responses, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 591, Pages: 1907-1920, ISSN: 0022-3751
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- Citations: 35
Kaski D, Saifee TA, Buckwell D, et al., 2013, Ocular Tremor in Parkinson's Disease Is Due to Head Oscillation, MOVEMENT DISORDERS, Vol: 28, Pages: 534-537, ISSN: 0885-3185
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- Citations: 23
Arshad Q, Nigmatullina Y, Bronstein AM, 2013, Handedness-Related Cortical Modulation of the Vestibular-Ocular Reflex, JOURNAL OF NEUROSCIENCE, Vol: 33, Pages: 3221-3227, ISSN: 0270-6474
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- Citations: 44
Scotto Di Cesare C, Anastasopoulos D, Bringoux L, et al., 2013, Influence of postural constraints on eye and head latency during voluntary rotations, VISION RESEARCH, Vol: 78, Pages: 1-5, ISSN: 0042-6989
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- Citations: 8
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