Imperial College London
Alternate

ProfessorAdolfoBronstein

Faculty of Medicine, Department of Brain Sciences

Emeritus Clinical Professor Head of Neuro-otology Unit
 
 
 
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Contact

 

+44 (0)20 3313 5525a.bronstein

 
 
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Assistant

 

Miss Lorna Stevenson +44 (0)20 3313 5525

 
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Location

 

10 L15bLab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bronstein:2019:brain/awy355,
author = {Bronstein, A and Bednarczuk, N and Bonsu, A and Casanovas, Ortega M and Fluri, A-S and Chan, J and Rust, H and de, Melo F and Sharif, M and Seemungal, B and Golding, J and Kaski, D and Arshad, Q},
doi = {brain/awy355},
journal = {BRAIN},
pages = {606--616},
title = {Abnormal visuo-vestibular interactions in vestibular migraine: a cross sectional study},
url = {http://dx.doi.org/10.1093/brain/awy355},
volume = {142},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Vestibular migraine is among the commonest causes of episodic vertigo. Chronically, patients with vestibular migraine develop abnormal responsiveness to both vestibular and visual stimuli characterized by heightened self-motion sensitivity and visually-induced dizziness. Yet, the neural mechanisms mediating such symptoms remain unknown. We postulate that such symptoms are attributable to impaired visuo-vestibular cortical interactions, which in turn disrupts normal vestibular function. To assess this, we investigated whether prolonged, full-field visual motion exposure, which has been previously shown to modulate visual cortical excitability in both healthy individuals and avestibular patients, could disrupt vestibular ocular reflex and vestibular-perceptual thresholds of self-motion during rotations. Our findings reveal that vestibular migraine patients exhibited abnormally elevated reflexive and perceptual vestibular thresholds at baseline. Following visual motion exposure, both reflex and perceptual thresholds were significantly further increased in vestibular migraine patients relative to healthy controls, migraineurs without vestibular symptoms and patients with episodic vertigo due to a peripheral inner-ear disorder. Our results provide support for the notion of altered visuo-vestibular cortical interactions in vestibular migraine, as evidenced by vestibular threshold elevation following visual motion exposure.
AU  - Bronstein,A
AU  - Bednarczuk,N
AU  - Bonsu,A
AU  - Casanovas,Ortega M
AU  - Fluri,A-S
AU  - Chan,J
AU  - Rust,H
AU  - de,Melo F
AU  - Sharif,M
AU  - Seemungal,B
AU  - Golding,J
AU  - Kaski,D
AU  - Arshad,Q
DO  - brain/awy355
EP  - 616
PY  - 2019///
SN  - 1460-2156
SP  - 606
TI  - Abnormal visuo-vestibular interactions in vestibular migraine: a cross sectional study
T2  - BRAIN
UR  - http://dx.doi.org/10.1093/brain/awy355
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30759189
UR  - http://hdl.handle.net/10044/1/67969
VL  - 142
ER  -
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