Imperial College London
Alternate

ProfessorAdolfoBronstein

Faculty of Medicine, Department of Brain Sciences

Emeritus Clinical Professor Head of Neuro-otology Unit
 
 
 
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Contact

 

+44 (0)20 3313 5525a.bronstein

 
 
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Assistant

 

Miss Lorna Stevenson +44 (0)20 3313 5525

 
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Location

 

10 L15bLab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Patel:2020:10.3233/VES-200693,
author = {Patel, M and Roberts, E and Arshad, Q and Bunday, K and Golding, JF and Kaski, D and Bronstein, AM},
doi = {10.3233/VES-200693},
journal = {Journal of Vestibular Research: Equilibrium and Orientation: an international journal of experimental and clinical vestibular science},
pages = {81--94},
title = {The "broken escalator" phenomenon: vestibular dizziness interferes with locomotor adaptation},
url = {http://dx.doi.org/10.3233/VES-200693},
volume = {30},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Although vestibular lesions degrade postural control we do not know the relative contributions of the magnitude of the vestibular loss and subjective vestibular symptoms to locomotor adaptation. OBJECTIVE: To study how dizzy symptoms interfere with adaptive locomotor learning. METHODS: We examined patients with contrasting peripheral vestibular deficits, vestibular neuritis in the chronic stable phase (n=20) and strongly symptomatic unilateral Meniere's disease (n=15), compared to age-matched healthy controls (n=15). We measured locomotor adaptive learning using the "broken escalator" aftereffect, simulated on a motorised moving sled. RESULTS: Patients with Meniere's disease had an enhanced "broken escalator" postural aftereffect. More generally, the size of the locomotor aftereffect was related to how symptomatic patients were across both groups. Contrastingly, the degree of peripheral vestibular loss was not correlated with symptom load or locomotor aftereffect size. During the MOVING trials, both patient groups had larger levels of instability (trunk sway) and reduced adaptation than normal controls. CONCLUSION: Dizziness symptoms influence locomotor adaptation and its subsequent expression through motor aftereffects. Given that the unsteadiness experienced during the "broken escalator" paradigm is internally driven, the enhanced aftereffect found represents a new type of self-generated postural challenge for vestibular/unsteady patients.
AU  - Patel,M
AU  - Roberts,E
AU  - Arshad,Q
AU  - Bunday,K
AU  - Golding,JF
AU  - Kaski,D
AU  - Bronstein,AM
DO  - 10.3233/VES-200693
EP  - 94
PY  - 2020///
SN  - 0957-4271
SP  - 81
TI  - The "broken escalator" phenomenon: vestibular dizziness interferes with locomotor adaptation
T2  - Journal of Vestibular Research: Equilibrium and Orientation: an international journal of experimental and clinical vestibular science
UR  - http://dx.doi.org/10.3233/VES-200693
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32116265
UR  - https://content.iospress.com/articles/journal-of-vestibular-research/ves200693
UR  - http://hdl.handle.net/10044/1/77834
VL  - 30
ER  -
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