Imperial College London
Alternate

ProfessorAdolfoBronstein

Faculty of Medicine, Department of Brain Sciences

Emeritus Clinical Professor Head of Neuro-otology Unit
 
 
 
//

Contact

 

+44 (0)20 3313 5525a.bronstein

 
 
//

Assistant

 

Miss Lorna Stevenson +44 (0)20 3313 5525

 
//

Location

 

10 L15bLab BlockCharing Cross Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Ahmad:2015:10.1016/j.jns.2015.09.006,
author = {Ahmad, H and Cerchiai, N and Mancuso, M and Casani, AP and Bronstein, AM},
doi = {10.1016/j.jns.2015.09.006},
journal = {Journal of the Neurological Sciences},
pages = {428--431},
title = {Are white matter abnormalities associated with “unexplained dizziness”?},
url = {http://dx.doi.org/10.1016/j.jns.2015.09.006},
volume = {358},
year = {2015}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - IntroductionAlthough cerebral small vessel disease is a significant contributor to the development of imbalance and falls in the elderly, whether it causes dizziness is not known.MethodsA retrospective case analysis was conducted for 122 dizzy patients referred to two neuro-otology tertiary centres in London and Pisa. Patients were divided into ‘explained’ causes of dizziness (e.g. benign positional vertigo, vestibular neuritis, orthostatic hypotension, cerebellar ataxias) and ‘unexplained’ dizziness. White matter hyperintensities (WMH) in MRI (T2 weighted and FLAIR sequences) were blindly rated according to the Fazekas scale.Results122 patients; 58 (mean age = 72, SD=7.95 years) in the ‘unexplained’ group and 64 (mean age=72.01, SD=8.28 years) in the ‘explained’ group were recruited. The overall frequency of lesions (Fazekas 1–3) significantly differed between groups (p=0.011). The frequency of severe lesions (Fazekas 3) was significantly higher in the ‘unexplained’ group (22%) than in the ‘explained’ group (5%; p=0.003).ConclusionIncreased severity of WMH in cases of unexplained dizziness suggests that such abnormalities are likely contributory to the development of dizziness. WM lesions may induce dizziness either because patients perceive a degree of objective unsteadiness or by a disconnection syndrome involving vestibular or locomotor areas of the brain.
AU  - Ahmad,H
AU  - Cerchiai,N
AU  - Mancuso,M
AU  - Casani,AP
AU  - Bronstein,AM
DO  - 10.1016/j.jns.2015.09.006
EP  - 431
PY  - 2015///
SN  - 0022-510X
SP  - 428
TI  - Are white matter abnormalities associated with “unexplained dizziness”?
T2  - Journal of the Neurological Sciences
UR  - http://dx.doi.org/10.1016/j.jns.2015.09.006
UR  - http://hdl.handle.net/10044/1/26157
VL  - 358
ER  -
Download