Imperial College London
Alternate

ProfessorAdolfoBronstein

Faculty of Medicine, Department of Brain Sciences

Emeritus Clinical Professor Head of Neuro-otology Unit
 
 
 
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Contact

 

+44 (0)20 3313 5525a.bronstein

 
 
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Assistant

 

Miss Lorna Stevenson +44 (0)20 3313 5525

 
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Location

 

10 L15bLab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Arshad:2016:cercor/bhv344,
author = {Arshad, Q and Bronstein, A},
doi = {cercor/bhv344},
journal = {Cerebral Cortex},
pages = {2311--2324},
title = {Bidirectional modulation of numerical magnitude},
url = {http://dx.doi.org/10.1093/cercor/bhv344},
volume = {26},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Numerical cognition is critical for modern life; however, the precise neural mechanisms underpinning numerical magnitude allocation in humans remain obscure. Based upon previous reports demonstrating the close behavioral and neuro-anatomical relationship between number allocation and spatial attention, we hypothesized that these systems would be subject to similar control mechanisms, namely dynamic interhemispheric competition. We employed a physiological paradigm, combining visual and vestibular stimulation, to induce interhemispheric conflict and subsequent unihemispheric inhibition, as confirmed by transcranial direct current stimulation (tDCS). This allowed us to demonstrate the first systematic bidirectional modulation of numerical magnitude toward either higher or lower numbers, independently of either eye movements or spatial attention mediated biases. We incorporated both our findings and those from the most widely accepted theoretical framework for numerical cognition to present a novel unifying computational model that describes how numerical magnitude allocation is subject to dynamic interhemispheric competition. That is, numerical allocation is continually updated in a contextual manner based upon relative magnitude, with the right hemisphere responsible for smaller magnitudes and the left hemisphere for larger magnitudes.
AU  - Arshad,Q
AU  - Bronstein,A
DO  - cercor/bhv344
EP  - 2324
PY  - 2016///
SN  - 1460-2199
SP  - 2311
TI  - Bidirectional modulation of numerical magnitude
T2  - Cerebral Cortex
UR  - http://dx.doi.org/10.1093/cercor/bhv344
UR  - http://hdl.handle.net/10044/1/28312
VL  - 26
ER  -
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