Imperial College London
Alternate

ProfessorAdolfoBronstein

Faculty of Medicine, Department of Brain Sciences

Emeritus Clinical Professor Head of Neuro-otology Unit
 
 
 
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Contact

 

+44 (0)20 3313 5525a.bronstein

 
 
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Assistant

 

Miss Lorna Stevenson +44 (0)20 3313 5525

 
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Location

 

10 L15bLab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Arshad:2017:10.1002/acn3.449,
author = {Arshad, Q and Bonsu, A and Lobo, R and Fluri, A and Sheriff, R and Bain, P and Pavese, N and Bronstein, A},
doi = {10.1002/acn3.449},
journal = {Annals of Clinical and Translational Neurology},
pages = {739--748},
title = {Biased numerical cognition impairs economic decision-making in Parkinson’s disease},
url = {http://dx.doi.org/10.1002/acn3.449},
volume = {4},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectivePrevious findings suggest a context-dependent bihemispheric allocation of numerical magnitude. Accordingly, we predicted that lateralized motor symptoms in Parkinson's disease (PD), which reflect hemispheric asymmetries, would induce systematic lateralized biases in numerical cognition and have a subsequent influence on decision-making.MethodsIn 20 PD patients and matched healthy controls we assessed numerical cognition using a number-pair bisection and random number generation task. Decision-making was assessed using both the dictator game and a validated questionnaire.ResultsPD patients with predominant right-sided motor symptoms exhibited pathological biases toward smaller numerical magnitudes and formulated less favorable prosocial choices during a neuroeconomics task (i.e., dictator game). Conversely, patients with left-sided motor symptoms exhibited pathological biases toward larger numerical magnitudes and formulated more generous prosocial choices. Our account of context-dependent hemispheric allocation of numerical magnitude in PD was corroborated by applying our data to a pre-existing computational model and observing significant concordance. Notably, both numerical biasing and impaired decision-making were correlated with motor asymmetry.InterpretationAccordingly, motor asymmetry and functional impairment of cognitive processes in PD can be functionally intertwined. To conclude, our findings demonstrate context-dependent hemispheric allocation and encoding of numerical magnitude in PD and how biases in numerical magnitude allocation in Parkinsonian patients can correspondingly impair economic decision-making.
AU  - Arshad,Q
AU  - Bonsu,A
AU  - Lobo,R
AU  - Fluri,A
AU  - Sheriff,R
AU  - Bain,P
AU  - Pavese,N
AU  - Bronstein,A
DO  - 10.1002/acn3.449
EP  - 748
PY  - 2017///
SN  - 2328-9503
SP  - 739
TI  - Biased numerical cognition impairs economic decision-making in Parkinson’s disease
T2  - Annals of Clinical and Translational Neurology
UR  - http://dx.doi.org/10.1002/acn3.449
UR  - http://hdl.handle.net/10044/1/50213
VL  - 4
ER  -
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