Imperial College London
Alternate

ProfessorAdolfoBronstein

Faculty of Medicine, Department of Brain Sciences

Emeritus Clinical Professor Head of Neuro-otology Unit
 
 
 
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Contact

 

+44 (0)20 3313 5525a.bronstein

 
 
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Assistant

 

Miss Lorna Stevenson +44 (0)20 3313 5525

 
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Location

 

10 L15bLab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bronstein:2017:10.1152/jn.00674.2016,
author = {Bronstein, AM and Panichi, R and Faralli, M and Bruni, R and Kiriakarely, A and Occhigrossi, C and Ferraresi, A},
doi = {10.1152/jn.00674.2016},
journal = {American Journal of Physiology},
pages = {2819--2832},
title = {Asymmetric vestibular stimulation reveals persistent disruption of motion perception in unilateral vestibular lesions},
url = {http://dx.doi.org/10.1152/jn.00674.2016},
volume = {118},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Self-motion perception was studied in patients with unilateral vestibular lesions (UVL) due to acute vestibular neuritis at 1 week, 4, 8 and 12 months after the acute episode. We assessed vestibularly-mediated self-motion perception by measuring the error in reproducing the position of a remembered visual target at the end of 4 cycles of asymmetric whole-body rotation. The oscillatory stimulus consists of a slow (0.09Hz) and a fast (0.38Hz) half cycle. A large error was present in UVL patients when the slow half cycle was delivered towards the lesion side, but minimal towards the healthy side. This asymmetry diminished over time, but it remained abnormally large at 12 months. In contrast, vestibulo-ocular reflex responses showed a large direction-dependent error only initially, then they normalized. Normalization also occurred for conventional reflex vestibular measures (caloric tests, subjective visual vertical and head shaking nystagmus) and for perceptual function during symmetric rotation. Vestibular-related handicap, measured with the Dizziness Handicap Inventory (DHI) at 12 months, correlated with self-motion perception asymmetry but not with abnormalities in vestibulo-ocular function. We conclude that 1) a persistent self-motion perceptual bias is revealed by asymmetric rotation in UVLs despite vestibulo-ocular function becoming symmetric over time 2) this dissociation is caused by differential perceptual-reflex adaptation to high and low frequency rotations when these are combined as with our asymmetric stimulus 3) the findings imply differential central compensation for vestibulo-perceptual and vestibulo-ocular reflex functions 4) self-motion perception disruption may mediate long-term vestibular-related handicap in UVL patients.
AU  - Bronstein,AM
AU  - Panichi,R
AU  - Faralli,M
AU  - Bruni,R
AU  - Kiriakarely,A
AU  - Occhigrossi,C
AU  - Ferraresi,A
DO  - 10.1152/jn.00674.2016
EP  - 2832
PY  - 2017///
SN  - 0002-9513
SP  - 2819
TI  - Asymmetric vestibular stimulation reveals persistent disruption of motion perception in unilateral vestibular lesions
T2  - American Journal of Physiology
UR  - http://dx.doi.org/10.1152/jn.00674.2016
UR  - http://hdl.handle.net/10044/1/50441
VL  - 118
ER  -
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