ProfessorAustinBurt

Faculty of Natural Sciences, Department of Life Sciences (Silwood Park)

Professor of Evolutionary Genetics

Contact

+44 (0)20 7594 2266a.burt

Location

Silwood ParkSilwood Park

Summary

Research Interests

Homing Endonuclease Genes (HEGs).
We have been studying the evolutionary dynamics of these nonMendelian selfish genes, particularly in yeasts.

Population Genetic Engineering.
I am interested in using selfish genetic elements to genetically manipulate natural populations; our first targets are the mosquitoes that transmit malaria.

Population Genomics and Phylogenetics of Yeasts.
The tremendous amount that is known about the biochemistry, genetics, and cell biology of yeasts makes them ideal model systems for addressing questions in evolutionary and population biology.

Molecular Ecology of a Pathogenic Mammal.
Canine Transmissible Venereal Tumor (CTVT) is a sexually transmitted parasitic cell line currently circulating in feral dog populations; we are interested in its origins and how it has adapted to its new way of life.

Selected publications

Windbichler N, Menichelli M, Papathanos PA, Thyme SB, Li H, Ulge UY, Hovde BT, Baker D, Monnat RJ, Burt A, Crisanti A, 2011 A synthetic homing endonuclease-based gene drive system in the human malaria mosquito. Nature 473:212-215 (doi)

Rebbeck CA, Leroi AM, Burt A, 2011 Mitochondrial capture by a transmissible cancer. Science 331:303 (doi)

Tsai IJ, Burt A, Koufopanou V, 2010 Conservation of recombination hotspots in yeast. Proc Natl Acad Sci USA, 107:7847-7852 (doi)

Tsai IJ, Bensasson D, Burt A, Koufopanou V, 2008 Population genomics of the wild yeast Saccharomyces paradoxus: Quantifying the life cycle. Proc Natl Acad Sci USA105 4957-4962 (doi)

Goddard MR, Godfray HC, Burt A, 2005 Sex increases the efficacy of natural selection in experimental yeast populations. Nature 434:636-640 (doi)

Burt A, Koufopanou V, 2004 Homing endonuclease genes: the rise and fall and rise again of a selfish element. Curr Opin Genet Dev 14:609-615 (doi)

Burt A, 2003 Site-specific selfish genes as tools for the control and genetic engineering of natural populations. Proc Roy Soc Lond B 270:921-928 (doi)

Book

Genes in Conflict: The Biology of Selfish Genetic Elements

Austin Burt and Robert Trivers

Genes in Conflict, The Biology of Selfish Genetic Elements - Austin Burt, Robert Trivers

Detailed contents [PDF format]
Information @ Harvard University Press website

Publications

Journals

Simoni A, Hammond AM, Beaghton AK, et al.Simoni A, Hammond AM, Beaghton AK, Galizi R, Taxiarchi C, Kyrou K, Meacci D, Gribble M, Morselli G, Burt A, Nolan T, Crisanti A close, 2020, A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae., Nature Biotechnology, ISSN:1087-0156

Hui T-YJ, Burt A, 2020, Estimating linkage disequilibrium from genotypes under Hardy-Weinberg equilibrium, Bmc Genetics, Vol:21, ISSN:1471-2156

Beaghton AK, Hammond A, Nolan T, et al.Beaghton AK, Hammond A, Nolan T, Crisanti A, Burt A close, 2019, Gene drive for population genetic control: non-functional resistance and parental effects, Proceedings of the Royal Society B: Biological Sciences, Vol:286, ISSN:0962-8452, Pages:1-8

Brown P, Tan A-C, El-Esawi MA, et al.Brown P, Tan A-C, El-Esawi MA, Liehr T, Blanck O, Gladue DP, Almeida GMF, Cernava T, Sorzano CO, Yeung AWK, Engel MS, Chandrasekaran AR, Muth T, Staege MS, Daulatabad SV, Widera D, Zhang J, Meule A, Honjo K, Pourret O, Yin C-C, Zhang Z, Cascella M, Flegel WA, Goodyear CS, van Raaij MJ, Bukowy-Bieryllo Z, Campana LG, Kurniawan NA, Lalaouna D, Huttner FJ, Ammerman BA, Ehret F, Cobine PA, Tan E-C, Han H, Xia W, McCrum C, Dings RPM, Marinello F, Nilsson H, Nixon B, Voskarides K, Yang L, Costa VD, Bengtsson-Palme J, Bradshaw W, Grimm DG, Kumar N, Martis E, Prieto D, Sabnis SC, Amer SEDR, Liew AWC, Perco P, Rahimi F, Riva G, Zhang C, Devkota HP, Ogami K, Basharat Z, Fierz W, Siebers R, Tan K-H, Boehme KA, Brenneisen P, Brown JAL, Dalrymple BP, Harvey DJ, Ng G, Werten S, Bleackley M, Dai Z, Dhariwal R, Gelfer Y, Hartmann MD, Miotla P, Tamaian R, Govender P, Gurney-Champion OJ, Kauppila JH, Zhang X, Echeverria N, Subhash S, Sallmon H, Tofani M, Bae T, Bosch O, Cuiv PO, Danchin A, Diouf B, Eerola T, Evangelou E, Filipp FV, Klump H, Kurgan L, Smith SS, Terrier O, Tuttle N, Ascher DB, Janga SC, Schulte LN, Becker D, Browngardt C, Bush SJ, Gaullier G, Ide K, Meseko C, Werner GDA, Zaucha J, Al-Farha AA, Greenwald NF, Popoola SI, Rahman MS, Xu J, Yang SY, Hiroi N, Alper OM, Baker CI, Bitzer M, Chacko G, Debrabant B, Dixon R, Forano E, Gilliham M, Kelly S, Klempnauer K-H, Lidbury BA, Lin MZ, Lynch I, Ma W, Maibach EW, Mather DE, Nandakumar KS, Ohgami RS, Parchi P, Tressoldi P, Xue Y, Armitage C, Barraud P, Chatzitheochari S, Coelho LP, Diao J, Doxey AC, Gobet A, Hu P, Kaiser S, Mitchell KM, Salama MF, Shabalin IG, Song H, Stevanovic D, Yadollahpour A, Zeng E, Zinke K, Alimba CG, Beyene TJ, Cao Z, Chan SS, Gatchell M, Kleppe A, Piotrowski M, Torga G, Woldesemayat AA, Cosacak MI, Haston S, Ross SA, Williams R, Wong A, Abramowitz MK, Effiong A, Lee S, Abid MB, Agarabi C, Alaux C, Albrecht DR, Atkins GJ, Beck CR, Bonvin AMJJ, Bourke E, Brand T, Braun RJ, Bull JA, Cardoso P, Carter D close, 2019, Large expert-curated database for benchmarking document similarity detection in biomedical literature search, Database: the Journal of Biological Databases and Curation, Vol:2019, ISSN:1758-0463, Pages:1-66

Khatri BS, Burt A, 2019, Robust estimation of recent effective population size from number of independent origins in soft sweeps, Molecular Biology and Evolution, Vol:36, ISSN:1537-1719, Pages:2040-2052

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