Imperial College London
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ProfessorAustinBurt

Faculty of Natural Sciences, Department of Life Sciences (Silwood Park)

Professor of Evolutionary Genetics
 
 
 
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Contact

 

+44 (0)20 7594 2266a.burt

 
 
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Location

 

Silwood ParkSilwood Park

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Summary

 

Publications

Citation

BibTex format

@article{Burt:2018:10.1098/rspb.2018.0776,
author = {Burt, A and Deredec, A},
doi = {10.1098/rspb.2018.0776},
journal = {Proceedings of the Royal Society B: Biological Sciences},
pages = {1--9},
title = {Self-limiting population genetic control with sex-linked genome editors},
url = {http://dx.doi.org/10.1098/rspb.2018.0776},
volume = {285},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In male heterogametic species the Y chromosome is transmitted solely from fathers to sons, and is selected for based only on its impacts on male fitness. This fact can be exploited to develop efficient pest control strategies that use Y-linked editors to disrupt the fitness of female descendants. With simple population genetic and dynamic models we show that Y-linked editors can be substantially more efficient than other self-limiting strategies and, while not as efficient as gene drive approaches, are expected to have less impact on non-target populations with which there is some gene flow. Efficiency can be further augmented by simultaneously releasing an autosomal X-shredder construct, in either the same or different males. Y-linked editors may be an attractive option to consider when efficient control of a species is desired in some locales but not others.
AU  - Burt,A
AU  - Deredec,A
DO  - 10.1098/rspb.2018.0776
EP  - 9
PY  - 2018///
SN  - 0962-8452
SP  - 1
TI  - Self-limiting population genetic control with sex-linked genome editors
T2  - Proceedings of the Royal Society B: Biological Sciences
UR  - http://dx.doi.org/10.1098/rspb.2018.0776
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000439907900011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://royalsocietypublishing.org/doi/10.1098/rspb.2018.0776
UR  - http://hdl.handle.net/10044/1/81801
VL  - 285
ER  -
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